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Patho final cards
Cards from all chapters of the semester
266
Medical
Undergraduate 3
05/09/2008

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Cards

Term
The increased metabolic rate and greater body surface area in infants makes them more succeptible to changes in what?
Definition
Total body water (dehydration)
Term
How does a decrease in oncotic pressure cause edema?
Definition
When pressure exceeds hydrostatic pressure, fluid is reabsorbed into circulation. Decrease in oncotic pressure fluid remains in the interstitial space, resulting in edema.
Term
Renal tubules are the site of action of ADH and aldosterone resulting in what?
Definition
Renal regulation of blood pressure
Term
Atrial natriuretic peptide causes vasodilation and increase in urinary excretion of sodium and water in which biologic process?
Definition
Cardiac regulation
Term
When cells neither shrink or swell, what is the characteristic of the fluid they are in?
Definition
It's an isotonic solution.
Term
When cells shrink because the ECF is more concetrated than the ICF, what is the nature of the fluid they are immersed in?
Definition
It's a hypertonic solution
Term
Less than 3.5mEq during hypoKalemia. Which area of the body will be most affected by the low potassium?
Definition
The cardiac area.
Term
The nurse inflates the pressure cuff to a ridiculous pressure for 3 minutes. The patient has carpal spasms and flexion at the wrist and joints with extension of fingers and adduction of the thumb. What type of trousseau sign is this and what does it mean?
Definition
A positive trousseau sign that means the patient is hypocalcemic.
Term
Inspiration and expiration in the lungs results in what?
Definition
Blowing off Co2 and leaving H2O.
Term
The kidneys reabsorb _________ or create new ________ from CO2 and water.
Definition
Bicarbonate
Term
When PH is greater than 7.45, PaCo2 is greater than 35, and HCo2 is normal, what is this condition called?
Definition
Respiratory alkalosis
Term
What is the action of the ascending loop of henli?
Definition
It reapsorbs Na+, Cl-, K+ so the urine is more dilute.
Term
What is the filtration of plasma per unit of time called?
Definition
GFR
Term
What is the GFR directly related to?
Definition
Perfusion pressure of renal blood flow!
Term
What is the normal GFR?
Definition
125ml/min. 180L/day
Term
When will renin be released and why?
Definition
In response to a decrease in blood pressure in order to regulate blood pressure.
Term
What is a potent vasoconstrictor causing the kidneys to lessen Na+ and water excretion?
Definition
Angiotensin II
Term
What substance stimulates the bone marrow to produce more RBCs and where is it produced?
Definition
Erythropoeitin is produced in the kidneys.
Term
Mg+ ammonium phosphate stones are also called?
Definition
Struvite stones
Term
A male patient is doubled over in pain which had an abrupt onset. The patient has colicky pain in the flank and upper quadrant with radiation to the bladder, taint, and junk. What does the nurse first suspect?
Definition
Renal calculi
Term
Most uncomplicated UTI are caused by which microorganism?
Definition
E. Coli
Term
A diagnosis is made for UTI when?
Definition
With the presence of 1 million or more bacteria per milliliter of urine.
Term
Inflammation of the tubules, interstitium, and renal pelvis is called what, and what is the most common cause of the chronic form?
Definition
It's called pyelonephritis and the most common form of the chronic form is reflux of urine due to obstruction.
Term
What is the leading cause of renal failure?
Definition
Glomerulonephritis
Term
What is a derangement in the glomerular membrane causing increased permeability to plasma proteins?
Definition
Nephrotic syndromes
Term
Increased irritation of the kidneys puts clients at risk for what disease?
Definition
Adult kidney cancer (renal cell carcinoma)
Term
What is the most common cause of intrinsic (intrarenal) failure.
Definition
Acute tubular necrosis
Term
What is the first sign of acute renal failure?
Definition
Polyuria is the first sign. The urine is dilute also. Kidney is not pulling out waste.
Term
Pruritis, uremic frost, hyperglycemia, hyperlipidemia, and osteodystrophy are all signs and symptoms of:
Definition
Chronic renal failure
Term
Failure of the chromosomes to separate during oogenesis or spermatogenesis occurs in the autosomes or the sex chromosomes
Definition
Nondisjunction
Term
Caused when a chromosome breaks and neucleoides are removed from the chain.
Definition
Deletion
Term
This happens when a chromosome breaks apart and comes back together in an inverted way. It's not a problem for that person, but can be a problem for the offspring.
Definition
Inversion
Term
This type of deletion codes for a premature stop in a protein resulting in a nonfunctional protein.
Definition
Nonsense mutation
Term
What is the risk of having a downs syndrome child between the ages of 35 and 41?
Definition
1 in 400
Term
What is the risk of having a down syndrome child in women aged 42-48?
Definition
1 in 60.
Term
What is the risk of having a down syndrome child for women age 49 and above?
Definition
1 in 12.
Term
Necrotic gummas in the liver, bone and testes problems are characteristics of which stage of syphilis?
Definition
The tertiary stage.
Term
Which disease is an autosomal dominant disease mapped to the long arm of chromosome 15?
Definition
Marfan's syndrome
Term
A woodford lasting more than four hours is known as what?
Definition
Priapism
Term
Which disorder is known as a bag or worms? a dialation of veins in the satchel?
Definition
Varicocele
Term
What is it known as when the testes don't descend and what are the possible complications?
Definition
Cryptorchidism. It can cause infertility.
Term
What is the most common cause of prostatitis?
Definition
E. Coli
Term
What ar ethe signs and symptoms of benign prostatic hyperplasia?
Definition
Hesitance, decrease in stream, and post-void dribbling!
Term
After spermatogenesis, where do the sperm go to mature?
Definition
The epididymis
Term
Nitric oxide is a ________ causing relaxation of muscle of the corpora ________, causing in flow of blood, resulting in ________.
Definition
vasodilator, cavernosa, erection
Term
What is the biggest risk factor for developing erectile dysfunction?
Definition
Smoking
Term
In ischemic (low flow) priapism, what happens?
Definition
There is a stasis of blood, resulting in a failure of detumescence (going down).
Term
Which hormone is necessary for normal female physical maturation, growth and development, reproductive processes, and general metabolic effects?
Definition
Estrogen
Term
What are the manifestations of pelvic inflammatory disease?
Definition
Lower abdominal pain, pain after menstrual period, purulent discharge, pelvic tenderness, painful cervix (tenderness isn't normal), and fever greater than 101.
Term
What the heck is endometriosis?
Definition
Found in etopic sites outside the uterus. Tissue may be small hemorrhagic lesion that may be surrounded by scar tissue. Bleeding into surrounding strictures can cause pain and development of pelvic adhesions.
Term
What are benign neoplasms of smooth muscle developed in the corpus of the uterus?
Definition
Leiomyomas
Term
Herniation of the bladder into the vagina which makes it feel like you always have to bear down?
Definition
Cystocele
Term
What is the number one risk factor for the development of cervical cancer?
Definition
HPV
Term
What STD is the most common and often results in ectopic pregnancy?
Definition
Chlamydia
Term
What organisms are the most common cause of mastitis and what the H is it?
Definition
Staph and Strep are the most common causes. It's an inflammation of the breasticles.
Term
In hypopituitarism with growth hormone deficiency, what are the clinical manifestations in males and females?
Definition
Females it's infertility. In males, it's impotence, mainly with added headache, letharge, and cold intolerance.
Term
Tasteless urine is a sign of what?
Definition
Diabetes insipidus
Term
SIADH results from a negative feedback system. It's most commonly seen in small cell lung cancer. What a main defining characteristic of it?
Definition
Dilutional hyponatremia
Term
Change in RBCs caused by change in production o fRBCs. dysfunction, or blood loss is what?
Definition
Anemia
Term
What does chronic blood loss lead to?
Definition
Iron deficiency anemia
Term
Tissue hypoxia can be caused by?
Definition
Abnormally low hemoglobin level.
Term
What mineral is required for DNA synthesis and red cell maturation?
Definition
Folate
Term
What type of anemia is iron deficiency anemia and how is it diagnosed?
Definition
Hemoglobin below 7-8g/DL
Term
This type of anemia leads to bone marrow failure. Can be cause by hemorrhage into tissues.
Definition
Aplastic anemia
Term
What vitamin deficiency is caused by malabsorption syndrome?
Definition
Vitamin K
Term
What is pancytopenia?
Definition
A decrease in all cells (red, white, and platelets)
Term
This is an autosomal recessive disease in which hemoglobin is deoxygenated and forms longg protein rods that make the cell sickle. The causes are dehydration and poor oxygenation?
Definition
Sickle cell anemia
Term
What type of edema is a hard pitting type caused by water being trapped in the interstitial space?
Definition
Myxedema
Term
What type of edema does hypothyroidism cause?
Definition
Myxedema
Term
What are some signs of hypoparathyroidism?
Definition
Muscle cramps, carpopedal spasm, positive trousseau's sign
Term
What can primary adrenal insufficiency cause and what are some manifestations?
Definition
Addison's disease. Manifestations are hyperkalemia and hyponatremia. A decrease in mineralcorticoid steroids.
Term
An increase in adrenal gland functioning can cause what disease and what is a major manifestation?
Definition
cushing's syndrome; manifestation is buffalo hump.
Term
name the 5 symptoms, of which someone must posses 3 to diagnose metabolic syndrome.
Definition
1. Waist larger than 35 in for females or 40 in for males.
2. triglycerides greater than or equal to 150mg/dl
3. HDL less than 50 mg/dl for females and less than 40mg/dl for males.
4. blood pressure greater than 130/85
5 fasting plasma glucose greater than 110
Term
What are some of the major symptoms of type II diabetes mellitus?
Definition
Obesity, chronic skin infections, pruritis, fatigue
Term
To be diagnosed with DM, what should the fasting plasma glucose be at?
Definition
126mg/dl
Term
How long is the lifespan of a hemoglobin molecule?
Definition
3 months or 90 days.
Term
What are some characteristics of DKA?
Definition
Hyperglycemia greater than 250, ketosis, metabolic acidosis (bicarb Hc03 greater than 15 and a decrease in pH 7.3)
Term
What is characterized by hyperglycemia greater than 600, dehydration, hyperosmolarity (plasma osmolarity greater than 310) with No ketoacidosis.
Definition
DM-HHNK (remember dehydration)
Term
Too little food, too much insulin oral diabetic meds, or extra exercise in diabetes mellitus can cause what?
Definition
Acute complications such as hypoglycemia
Term
What is the leading cause of end-stage renal failure?
Definition
Nephropathy
Term
What are some characteristics of end stage renal disease?
Definition
Increase in urinary albumin excretion (30-eoomg/day) seen with HgA1C levels greater then 8.1%.
Term
What is the most common cause of newly diagnosed blindness b/w the ages of 20 and 74?
Definition
Diabetic retinopathy. Typical with type I after 20 years of DM, poor glucose control, HTN, and hyperlipidemia.
Term
What are some ways to avoid the chronic complication of diabetic foot ulcers?
Definition
Fitted shoes, daily foot inspections, avoid smoking, avoid cold, cut toenails straight across, avoid lotion between toes.
Term
What does the epstein barr virus trtansmitted via oral roit cause and who is it more common in?
Definition
Causes infectious mononucleosis; most common in adolescent and young adults between 15 and 30.
Term
These diseases arise from hematopooietic precursors in the bone marrow and can involve lymphocytes, granulocytes and "white blood"
Definition
LEukemias
Term
This disease has the presence of reed sternberg cells
Definition
Malignant hodgkins lymphoma
Term
Which leukemia is more common in children and when does it peak?
Definition
ALL (acute lymphocyitic) and it peaks from 2-4 years old.
Term
which type of leukemia has the presence of philadelphia chromosomes?
Definition
Chronic myelocytic leukemia.
Term
Bone marrow expansion in leukemia causes what?
Definition
Bone pain
Term
Bence jones proteins are present in which type of leukemia, and how are they found?
Definition
Present in multiple myeloma, and they are excreted in urine.
Term
Which type of proteins, are found in a certain type of leukemia and are toxic to renal tubules of the kidneys?
Definition
Bence Jones proteins
Term
What is a decrease in the number of circulating platelets known as?
Definition
Thrombocytopenia
Term
How is thrombocytopenia diagnosed?
Definition
By doing a platelet count below 20000.
Term
What are some of the major manifestations of thrombocytopenia?
Definition
petechiae, purpura (purple areas of bruising)
Term
What is one of the most common causes of thrombocytopenia?
Definition
Diseases of the bone marrow such as aplastic anemia.
Term
What is an autoimmune disorder that results in platelet antibody formation and excessive destruction of platelets, and what does it normally follow?
Definition
Idiopathic thrombocytopenic purpura. It normally follow a viral infection in children.
Term
This disease is characterised by multiple lymph node enlargement, widespread, extranodal envolvement, and onset after 50.
Definition
Non-hodgkins lymphoma (NHL)
Term
What are some of the main characteristics of non-hodgkins lymphoma?
Definition
Onset after 50, can develop abdominal pain, lung problems, spleen enlargement (not seen with hodgkins)
Term
What is a change in RBCs caused by a change in production of RBCs, dysfunction, or chronic blood loss ?
Definition
Anemias
Term
What is a main manifestation of anemia?
Definition
Tissue hypoxia and abnormally low oxygen level.
Term
What substance is required for DNA synthesis and red cell maturation?
Definition
Folate
Term
What type of anemia is iron deficiency anemia?
Definition
Microcytic-hypochromic
Term
How is iron deficiency anemia diagnosed?
Definition
By finding a hemoglobin level below 7-8g/dl
Term
Aplastic anemia, and/or hemorrhage into tissue can lead to what disorder?
Definition
Bone marrow failure
Term
What is the name for a decrease in all blood cells?
Definition
Pancytopenia
Term
What type of disease is Sickle cell classified as?
Definition
Autosomal recessive
Term
The jaw enlargement is a characteristic of which blood disorder?
Definition
Thalassemia
Term
What is plethora?
Definition
A ruddy red color and red rosy face and hands
Term
People with polycithemia are at risk for developing what syndrome?
Definition
Plethora
Term
What is a common age-related change in RBCs in the neonate?
Definition
Increased level of serum bilirubin, causing jaundice.
Term
What is the first main lesion of atherosclerosis?
Definition
A fatty streak (thin, flat, yellow intimal discolorations that progressively become thicker)
Term
What is the difference between a thrombus and an embolus?
Definition
An embolus is circulating and a thrombus is a stationary clot.
Term
What is stable angina?
Definition
In stable angina, the person has a stable fixed atherosclerotic plaque, but no damage. Pain is provoked when the heart's oxygen demand is increased.
Term
When does variant angina occur and what is it?
Definition
Occurs during the night or with exercise. It's a spasm of the coronary artery.
Term
What is cardiac tamponade?
Definition
When rapic accumulation of exudates compresses the heart.
Term
With fibrous pericarditis, what is common?
Definition
Friction rub, adhesions, ST elevation in all 12 leads.
Term
What is the diff between stenosis and regurgitation?
Definition
In stenosis, the valve does not open all the way. It is harder to force blood through. In regurgitation, the valve will not close al the way. It leaks when it should be closed.
Term
What side of the heart doea mitral valve prolapse occur on?
Definition
The left side.
Term
What are the two most common causes of aortic stenosis, and what is it?
Definition
Rheumatic fever and congenital valve malformation. It is an increased resistance to ejection of blood from the left ventricle to the aorta causing systemic blood decrease.
Term
What heart disease is most common to intravenous drug users?
Definition
Infective endocarditis (bacterial endocarditis) characterized by right sided tricuspid lesions.
Term
What happens in transposition of the great vessel?
Definition
Pulmonary artery and aorta are reversed. PA leaves left ventricle instead of right.
Term
What is narrowing of the aorta near the ductus arteriosus known as?
Definition
Coarctation of the aorta
Term
Weak or absent peripheral pulses of legs and bounding pulses of the arms in kids could be caused by what heart defect?
Definition
Coarctation of the aorta.
Term
When the heart fails to pump blood adequately, causing decreased cardiac output, which lowers BP, sympathetic sustem responds, vasoconstriction increases resistance to blood flow, and the workload on the heart is increased, worstening heart failure, what is this called and when does it happen?
Definition
Cardiogenic shock. Follows MI.
Term
What is it called when neurogenic shock caused by brain or spinal cord injury cause a decrease in sympathetic control of blood volume due to a defect in the vasomotor center w/ symptomatic outflow to the brain?
Definition
Distributive shock
Term
What is nephrolithiasis?
Definition
Kidney stones
Term
What is diminished blood volume known to cause when there is an inadequate filling of the vascular compartment?
Definition
Hypovolemic shock
Term
What is an abnormal pattern of respiration that increases in depth and sometimes in rate followed by periods of apnea. . .who is it most often seen in and why?
Definition
Cheyne-stokes respirations, normally seen in comatose patients because of NS disruption.
Term
What is an increase in PaCO2 also known as?
Definition
Hypercapnia
Term
What can hypercapnia progress to?
Definition
Respiratory acidosis.
Term
What are the levels of PaO2, PaCO2, and pH in acute respiratory failure?
Definition
PaO2<60mmHg is the main one you need to know... also, PaCO2 is greater then or equal to 50 and pH is less than or equal to 7.25
Term
What is incomplete expansion of a lung known as?
Definition
Atelectasis
Term
What is seen most commonly in persons with pleural effusion from CHF or cancer?
Definition
Atelectasis
Term
What can usually be heard over areas of effusion?
Definition
Pleural friction rub
Term
What the hell is it when there is lymph fluid in the lungs?
Definition
Chylothorax (lymphoma)
Term
What is an accumulation of AIR in the pleural cavity that leads to partial or complete lung collapse? And what is a characteristic of the chest wall movement seen with it?
Definition
Pneumothorax. There will be asymmetrical chest wall movement.
Term
What is the most common cause of secondary spontaneous pneumothorax?
Definition
Emphysema
Term
What is the primary difference between chronic bronchitis and emphysema?
Definition
Respiratory responsiveness to hypoxic stimuli
Term
With this condition, you have increased mucus production. Hypersecretion of mucus and productive cough lasts 3 consecutive months for at least 2 consecutive years.
Definition
Chronic bronchitis
Term
In emphysema, what helps prevent airway collapse?
Definition
Pursed lips
Term
Which disease is an autosomal recessive disorder whose common symptoms of steatorrhea, diarrhea, and abdominal pain?
Definition
Cystic fibrosis
Term
What test is used to test for CF?
Definition
A chloride sweat test
Term
What is a respiratory disorder characterized by sudden chest pain, tachypnea and dyspnea?
Definition
Pulmonary embolism
Term
Increased hypertension with pulmonary HTN places a strain on what part of the heart?
Definition
The right ventricle. It has to work harder than usual aganst this resistance to move adequate amounts of blood through the lungs.
Term
What is the first sign of hypoxemia (low PO2)?
Definition
Restlessness
Term
PCo2 may be asymptomatic until when?
Definition
until PCo2 levels are severely high
Term
What are the risk factors for pneumonia?
Definition
Advanced age, immuno-compromised, underlying lung disease (COPD), alcoholism, altered consciousness, smoking, endotracheal intubation, malnutrition, and immobilization
Term
What is the most common cause of community acquired pneumonia?
Definition
Streptococcus pneumonia (gram +)
Term
How is tuberculosis transmitted from person to person, and what are the main symptoms?
Definition
Transmitted from person to person in AiR BORNE droplets (coughing, sneezing and talking). The main symptoms are weight loss, decreased appetite, FATIGUE, NIGHT SWEATS and CHILLS.
Term
Brain metastasis is very common in which type of lung cancer?
Definition
Small cell carcinoma (oat cell)
Term
Which type of cancer is more amenable to early detection?
Definition
squamous cell carcinoma
Term
Which type of lung cancer originates in cetral bronchi in mostly men and smokers?
Definition
Squamous cell carcinoma
Term
"I cause a child to have inspiratory stridor, hoarsness, barking cough, and nasal flairing. What am I?"
Definition
Croup (Laryngeotracheobronchitis)
Term
Child is sitting up with mouth open, drooling, chin thrust forward, difficulty swallowing, fever and extreme anxiety. What does he have?
Definition
Epiglottitis.
Term
What is a viral infection of the lower airways caused by viral RSV?
Definition
Bronchiolitis
Term
What is a condition that manifests as heartburn occurring 30-60 mins after a meal that is worse with bending down and relieved by sitting straight up?
Definition
GERD
Term
What is a transient inflammation of the gastric mucosa, caused by staphylococcal enterotoxins and what are the manifestations?
Definition
Acute gastritis, and the manifestations are an abrupt and violent onset usually 5 hours after ingestion of contaminated food sources and may be mistaken for food poisoning.
Term
Which condition is characterized by pain relieved by food or antacids?
Definition
Peptic ulcer disease
Term
What type of ulcer develops in relation to major physiologic stress (trauma, burns, liver faiure, major surgical procedures)?
Definition
Curling/stress ulcer (curling was on the test)
Term
What condition is characterized by pain relieved with defecation and associated with a change in consistency or frequency of stools?
Definition
Irritable bowel syndrome
Term
Which condition is characterized by intermittent diarrhea, colicky RLQ pain, weight loss, malaise, and low grade fever?
Definition
Chron's disease. Another distinguishing characteristic is cobblestone appearance of the gastric mucosa.
Term
What is a nonspecific inflammatory condition of the colon and rectum manifested as frequent diarrhea (30-40 movements per day), typically with bliid and mucus, muld abd cramping and fecal incontinence, anorexia, weakness and fatigue?
Definition
Ulcerative colitis
Term
"I cause LLQ pain with N/V, slight fever and elevated WBC. Who am I"
Definition
Diverticulitis
Term
What would you be most concerned about in terms of the gastric area for a patient that just got out of surgery?
Definition
Paralytic ileus
Term
What is a rigid (board-like) abdomen a manifestation of?
Definition
Peritonitis
Term
What is a symptom of malabsorption syndrome?
Definition
Fractures and tetany, bruising, bleeding, and failure to absorb fat-soluble vitamins.
Term
What is celiac disease and how is it diagnosed?
Definition
AKA gluten sensitive enteropathy. Diagnosed by serum IgA.
Term
What are the risk factors for esophageal cancer?
Definition
Elderly, average age 67 y/o. Alcohol and tobacco use.
Term
What are the risk factors for esophageal cancer?
Definition
Elderly, average age 67 y/o. Alcohol and tobacco use.
Term
Pruritis occurs when bile acids accumulate in the blood, clay colored stool, DARK URINE, yellowing skin and sclera. . .what is it?
Definition
Jaundice
Term
Pruritis occurs when bile acids accumulate in the blood, clay colored stool, DARK URINE, yellowing skin and sclera. . .what is it?
Definition
Jaundice
Term
What hepatitis is caused by eating contaminated shellfish?
Definition
Hepatitis A
Term
Fulminating hepatitis is associated with which Hep virus?
Definition
Hep B
Term
What is an end stage chronic liver disease which functional tissue is replaced with fibrous disrupting blood flow?
Definition
Cirrhosis
Term
What is cholelithiasis?
Definition
Gall stone formation
Term
What chronic disease manifests with signs of diabetes mellitus, and malabsorption syndrome (steatorrhea, weight loss)?
Definition
Chronic pancreatitis
Term
Alpha feta-protein presence is used to diagnose what?
Definition
Primary liver cancer
Term
What are the 5 cardinal signs of inflammation?
Definition
Rubor, tumor, calour, dolor, and function laesa.
Term
Redness and warmth result from congestions in capillaries in acute inflammations.
Definition
True
Term
During this stage of inflammation, white blood enters the injured tissue releasing more inflammatory mediators to control further inflammation and healing?
Definition
Cellular stage
Term
What is the primary phagocyte of inflammation and when does it arrive on the scene?
Definition
Neutrophils. Within 90 min.
Term
Which phagocytes engulf bacteria?
Definition
Monocytes.
Term
Macrophaves accumulate in the damaged area and keep releasing inflammatory mediators in this kind of inflammation
Definition
Chronic inflammation
Term
What is tissue organization is controlled by what?
Definition
The extracellular matrix
Term
What is a main factor that affects wound healing?
Definition
Malnutrition
Term
What is type 1 hypersensitivity mediated by?
Definition
IgE (mast cells)
Term
De-granulation of _______ cells cause a release of ______.
Definition
Mast; histamine
Term
What type of hypersensitivity is RH and ABO reactions?
Definition
Type II, cytotoxic
Term
Which hypersensitivity can be detected with a tuberculin test?
Definition
type IV (cell mediated) hypersensitivity.
Term
What is an example of host v. graft?
Definition
Transplant rejection
Term
How long does the latent period of HIV infection last?
Definition
10-11 years or longer
Term
Which type of immunity does not distinguish between different pathogens?
Definition
Innate/natural immunity
Term
What type of immunity has components which include T and B lymphocytes?
Definition
Acquired/adaptive immunity
Term
This is a substance recognized as foreign by the body which stimulates an immune response?
Definition
Antigens
Term
Which immunoglobulins are found on mast cells and tissues that start on inflammation?
Definition
IgE
Term
What is the first antibody to be made in an infant and the 1st circulating immunoglobulin to appear in response to an antigen?
Definition
IgM
Term
These antigens play a role in transplant rejection.
Definition
HLA (Human leukocyte antigens)
Term
T Helper cells must activate B cells how do they do this?
Definition
By releasing cytokines in the primary immune response.
Term
What is the process of cel division?
Definition
Proliferation
Term
What is the process of specialization, whereby new cells acquire the structure and function of the cells they replace?
Definition
Differentation
Term
When differentiated cells mutate, what type of tumors do they form?
Definition
Working cells mutate, they form working or "benign" tumors.
Term
What type of tissue can liberate enzymes and toxins that destroy tumor tissue and normal tissue?
Definition
Malignant neoplasms (tumors)
Term
Is an osteoma malignant or benign, and where does it originate?
Definition
A benign bone tumor.
Term
How are malignant tumors named?
Definition
According to the cell type they originated from.
Term
What type of malignant tumor might you find on the surface of the skin?
Definition
A squamous cell carcinoma
Term
What is the name of a tumor originating from striated muscle?
Definition
Rhabdomyosarcoma
Term
What is the tumor marker for ovarian cancer?
Definition
ca-125
Term
In metastasis, what is invaded?
Definition
The surrounding extracellular matrix is envaded.
Term
What is the development of the new vascular supply that provides nutrients to facilitate tumor growth?
Definition
Angiogenesis
Term
What does laminin do?
Definition
It's an attachment factor that aids in attachment of an invading neoplasm to the matrix.
Term
What is oncogenesis?
Definition
The process whereby normal cells are transformed into cancer cells.
Term
What are the normal genes that code for notmal proteins used in cell division called?
Definition
Proto-oncogenes.
Term
These substances can interrupt the production of tumor cells until a defect in normal cells is corrected.
Definition
Tumor supressor proteins.
Term
Esphagus, stomach, and bladder cancer, as well as myeloid lukemia are all related to what?
Definition
Smoking
Term
What is an example of a diet-related carcinogen?
Definition
Grilled fish and meats such as BBQ chicken.
Term
What is a manifestation in a site not directly affected by the disease known as?
Definition
A paraneoplastic syndrome.
Term
What is removal of a tissue for microscopic study?
Definition
A biopsy
Term
What is a type of bone tumor common in children?
Definition
Ewing sarcoma
Term
What is a characteristic of most childhood cancers that is opposite that of adults?
Definition
Common metastasis at time of diagnosis.
Term
What is another name for a freckle?
Definition
macule
Term
What is an elevated, irregular-shaped area of cutaneous edema that is solid, transient and variable in diameter, and when is it generally found?
Definition
A Wheal. It is generally found in an allergic reaction.
Term
What disease commonly produces vesicles?
Definition
Chicken pox (varicella)
Term
What is a honey-crusted pustule commonly seen in?
Definition
Impetigo.
Term
What is the most common cause of impetigo?
Definition
Staph aureus.
Term
What is a common benign papilloma caused by DNA containing HPV?
Definition
Warts
Term
What is a viral infection of the skin and mucous membranes that is usually confined to the mouth and spread by respiratory droplets?
Definition
Type 1 Herpes simplex virus
Term
Common inflammatory skin disease characterized by circumscribed, red, thickened plaques with an overlying silvery white scale?
Definition
Psoriasis
Term
What type of butn is superficial and involves the outer later of the epidermis only.
Definition
First degree. They're very painful.
Term
How can the pain of a 3rd degree burn be described?
Definition
There is no pain because the pain sensors are destroyed.
Term
What does calcitonin do?
Definition
It inhibits the release of calcium from bone.
Term
When is calcitonin released, and where from?
Definition
It is released from the thyroid gland when serum calcium is too high.
Term
What is a strain?
Definition
Injury to a muscle or tendon.
Term
What is a sprain?
Definition
An injury to ligament or joint.
Term
What type of bone disorder deals with vascular insufficiency?
Definition
Osteomyelitis
Term
What type of bone disease in adults can spread to the joint spaces?
Definition
Hematogenous osteomyelitis
Term
What is crystallization caused by in gout?
Definition
Serum uric acid
Term
What is the condition that results in decreased compartment size, increased volume of contents, or both?
Definition
Compartment syndrome
Term
What is a partial dislocation in which the bone ends in the joint are still in partial contact with each other?
Definition
Subluxation
Term
Which condition causes defective mineralization, but not loss of matrix?
Definition
Osteomalacia
Term
What is a main characteristic of osteoarthritis?
Definition
Crepitus and grinding
Term
Is the swelling with rheumatoid arthritis symmetric or asymmetric?
Definition
Symmetric
Term
What is a malignant tumor of the cartilage that is often painless?
Definition
Chondrosarcoma
Term
What is a characteristic of postural scoliosis?
Definition
It corrects with bending
Term
How would you describe pain which is diffuse and poorly localized such as pain originatin in the abdominal or thoracic area?
Definition
Visceral pain
Term
Which type of pain is generally manifested by grimaces or facial tics?
Definition
Trigeminal neuralgia
Term
What is a headache that is unilateral, pulsatile and throbbing, and may move?
Definition
A migraine
Term
What muscle is most commonly affected with MG?
Definition
The periorbital muscle.
Term
What is an early sign of LMN symptoms?
Definition
Muscle spasms in the legs (distal limbs).
Term
What is the most common clinical feature of MS?
Definition
Fatigue
Term
What will be the result of spinal cord transsection below t12?
Definition
flaccid paralysis
Term
What can becuased by a spinal cord injury above t6 that will manifest as really high BP (240/120), sweating, increased level of injury, and anxiety?
Definition
Autonomic dysreflexia
Term
What is an effect of spinal shock?
Definition
Temorary flaccid paralysis
Term
What is the most common reason for developing a herniated intevertebral disk?
Definition
Trauma
Term
What are the 3 cardinal symptoms of parkinson's disease?
Definition
tremor, rigidity and bradykinesia
Term
What is another name for the LMN cells?
Definition
Anterior horn cells
Term
Besides the LMN, what other neuron cells does lou gherig's disease affect?
Definition
UMN cells of the cerebral cortex and the motor nuclei of the brain stem
Term
What happens when in the white matter, fluid is allowed to escape into the ECF that surrounds the brain cells, and what else happens as a hallmark characteristic of this disorder?
Definition
Vasogenic edema; BBB integrity is disrupted
Term
What does coup-contracoup injury lead to?
Definition
Permanant destruction of brain cells
Term
What is the most sesitive and important indicator of a patient's mental status?
Definition
Level of consciousness
Term
What does decorticate posturing indicate?
Definition
Lesions of the cerebral hemisphere (elbows flexed)
Term
What is a congenital tangle of arteries and veins frequently found in the middle cerebral artery?
Definition
An arteriovenous malformation
Term
What type of stroke is caused by atherosclerotic plaques?
Definition
Large vessel or "Thrombotic" stroke
Term
Nuccal rigidity is a sign of what condition?
Definition
Meningitis
Term
What is a funny feeling before a seizure occurs?
Definition
Aura
Term
What is the state after a seizure has occured and why is the patient drowsy and lethargic?
Definition
Known as the post-ictal state. They are drowsy and lethargic because they have depleated their energy/O2 stores.
Term
What is the second stage of alzheimer's marked by?
Definition
Confusion
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