___ is a DNA virus

Human Herpes Virus

two types of this virus (type 1 &2) and humans are the only natural reservoir

Human Herpes Virus

infected saliva or active perioral lesions

Herpes Simplex Virus 1 (HSV-1)

sexual contact

Human Simplex Virus 2 (HSV-2)

typically occurs at young age and often asymptomatic, virus is taken up by sensory nerves and transported to sensory ganglia

Primary Infection of HSV

in children, this virus causes gingivostomatitis, has an abrupt onset, lymphadenopathy, fever, anorexia, and oral lesions, and usually resolve in 5-7days

Primary Infection of HSV

in adults, this virus causes pharyngotonsillitis, sore throat, fever, malaise, headache, and small vesicles are seen in back of mouth

Primary Infection of HSV

symptomatic recurrences are common, usually acquired - contaminated saliva or active perioral lesions

Secondary or Recurrent Infection

at a site of inoculation or adjacent epithelium supplied by the involved ganglion

Recurrent Infection of HSV

where is the most common site for recurrent infection of HSV?

herpes labialis (cold sore, fever blister)

____signs: pain, burning, itching, tingling, localized warmth, or erythema

Prodromal

heals within 7-10days, vesicles rupture and crust within 2days

Recurrent Infection of HSV

lesions limited to keratinized mucosa

Recurrent Infection of HSV

herpetic infection found on the fingers

Herpertic Whitlow

these cells are found under a Bx of a herpes lesion

Tzank Cells

VZV: HHV-3

Varicella (Chickenpox)

this is a herpes zoster secondary infection

Varicella

malaise, pharyngitis, rhinitis, intensly itchy rash

Clinical Features of Varicella

lesion rapidly progresses thought stages of eythema, vasicle, pustule, and harden crust

Clinical Features of Varcella

succestive crops over 3-4days, contagious from 2days before until all lesions crust, more severe in adults

Varicella

oral lesions are uncommon, but tend to be painless, and gingival lesions resemble primary herpes

Varicella

establishes latency in dorsal spinal ganglia, prevalence increases with age, single rather than multiple recurrences

Herpes Zoster (Shingles)

HHV4 is another name for what?

Epstein-Barr Virus (EBV)

acute EBV infeciton, proliferation of B lymphocytes

Infectious Mononucleosis

lymphadenopathy, hepatosplenomegaly, fatigue, rash

Infectious Mononucleosis

one can get severe tonsillitis

HHV4 - Mononucleosis

palatal petechiae are a common finding

HHV4 - Mononucleosis