Term
| define etiology, what are the two types, how are they interconnected (give example situation) |
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Definition
cause of disease
intrinsic and acquired
both types work together to cause disease: environmental factors add to risk and development of an intrinsic disease |
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Term
| define intrinsic etiology |
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Definition
| genetic causes (mutations) lead to malfunction proteins which lead to increased disease susceptability |
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Term
| what are causes of acquired etiology |
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Definition
| infections, environmental (smoking), nutrition |
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Term
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Definition
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Term
| define morphologic changes |
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Definition
| alteration in cell, tissue, or organs the lead to a pathology |
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Term
| define clinical significance in three ways |
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Definition
functional consequences of a disease
how morphological changes lead to dysfunction
manifestations of signs (objective) and symptoms (subjective) |
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Term
| what is clinical significance altered / dependent on |
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Definition
| severity of chenges influences course of prognosis of the disease |
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Term
| use huntingtons disease as an example of the pathology core |
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Definition
etiology: intrinsic
pathology: LMNA mutation
morphologic changes: causes changes in nuclear envelope
clinical significance: aging more quickly |
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Term
| use celiac disease as an example of the pathology core |
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Definition
etiology: intrinsic and extrinsic
pathology: genetic susceptibility, rotavirus causes susceptibility
morphologic changes: alteration in structure of intestine villi
clinical significance: gluten intolerance, failure to thrive |
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Term
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Definition
| functional changes as a result of a disease of injury |
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Term
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Definition
| MOA of pathologic changes |
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Term
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Definition
| cannot be measured objectively (counted, measured, tested) |
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Term
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Definition
| condition with defined etiologic agent/cause |
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Term
| give and example of a disease and explain why it is called that |
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Definition
| Cushing disease: caused by pituitary tumor (defined etiology) which increases ACTH and thus cortisol |
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Term
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Definition
undefined, multiple, or unknown etiology for a condition
collection of signs and symptoms frequently found together |
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Term
| give and example of a syndrome and explain why it is called that |
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Definition
cushing syndrome: can be due to adrenal gland, cancer, or medications
multiple causes |
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