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Path Head and Neck
KYCOM Block 15
177
Pathology
Graduate
04/02/2014

Additional Pathology Flashcards

 


 

Cards

Term
4 things that cause inflammation of the oral cavity
Definition
herpes simplex 1
apthous stomatitis
oral candidiasis (thrush)
glossitis
Term
who gets and what are the signs of a HSV1 primary infection
Definition
usually 2-4yo and symptomatic then becomes domant in trigeminal
acute herpetic ginbivostomatitis: abrupt onset of vesicles and ulcerations on the lip
Term
what is it called when HSV 1 is reactivated
Definition
recurrent herpetic stomatitis
Term
causes of HSV1 reactivation 7
Definition
trauma, allergies, UV light, URI, pregnancy, mensturation, immune supression
Term
symptoms of HSV1 reactivation
Definition
herpes labialis: groups of 1-3mm vesicles on lips
also on nasal oriface, buccal mucosa, gingiva, hard palate
shalloe painful red ulcer
outbreaks are milder and shorter in duration
Term
prognosis of HSV1 reactivation
Definition
resolves in 7-10d
persistant in immune compormised
Term
how is HSV1 diagnosed
Definition
tzank test: multinucleated giant cells on lesion floor with eosinophil inclusions
Term
apthous stomatitis aka
Definition
apthous ulcer
canker sore
Term
signs of aphthous stomatitis
Definition
painfull, recurrent, solitary or multiple, thin exudate govering with gray base, erythema around
Term
what diseases have increased aphthous stomatitis 3
Definition
celiac, IBD, bechets
Term
prognosis of aphthous stomatitis
Definition
spontaneously resolve in 7-10d but can reoccur
Term
bechets disease: cause, 3 signs
Definition
immune complex casculitis of small vessels

aphthous ulcers, genital ulcers, uveitis
Term
clinical signs of oral thrush
Definition
pseudomembranes: superificial curd gray-white inflammation, fibrosuppurative exudate, can be scraped off, red base
erythematous and hyperplastic
Term
3 prognosis of thrush and why are there 3
Definition
antibiotics: invades body when flora composition changes
immune supression: disseminates in very immune supressed (transplants, neutropenia, chemo, AIDS)

stays superificial in minor immune supression (DM, xerostoma, antibiotics, steroid)
Term
glossitis: define, appearance, causes 3
Definition
inflammation of tongue, beefy red, jagged carious teeth, ill fitting dentures

plummer vinson syndrome, patterson kelly syndrome, nutritional deficiency
Term
3 signs of patterson kelly syndrome
Definition
glossitis
Fe deficiency anemia, esophageal dysplasia
Term
4 reactive leasons of the mouth
Definition
irritation fibroma
pyogenic granuloma
peripherial ossifying fibroma
peripherial giant cell granuloma
Term
irritation fibroma: cause, morphology, location, tx
Definition
chronic irritation of the buccal mucosa on bite line causes submucosa nodular fibrous mass and CT hyperplasia

surgical excision if source of irritation
Term
pyogenic granuloma; who 3, cause, complication, tx
Definition
kids, young adults, pregnant women
ret purple pedunculated capillary hemangioma of gingiva
immature vessels rapdly appear

can regress and turn into dense fibrous mass or peripherial ossifying fibroma

complete surfical excision is curative
Term
measles: 1 oral manifestations, 2 locations
Definition
koplick spots, precede rash
often on buccal mucosa and around stinsens duct
Term
scarlet feve: 4 oral manifestations
Definition
fire red tongue
prominent papillar rasberry tongue
white coating
Term
mono: 3 oral manifestations
Definition
pharyngitis
tonsilitis
gray white exudate
Term
diptheria: 4 oral manifestations, 2 locations
Definition
dirty white
fibrosuppurative
tough
inflammation membrane
on tonsils and retropharynx
Term
HIV oral manifestations 4
Definition
candidia
other fungi
kaposki sarcoma
hairy leukoplakia
Term
lichen planus oral manifestations 5
Definition
reticulate
lace
white keratotic lesions
ulcerated
Term
phemigus oral manifestations 3
Definition
usually vulgaris
bullae prone to rupture leaving hyperemic erosions
Term
bullous phemigoid oral manifestation morphology
Definition
like macrophage phemigus but different histologically
Term
erythema multiform/SJS oral manifestation 2 and causes 3
Definition
maculopapular, vestilobullous
follows infection, drug, collagen vascular disease
Term
pancytopenia/leukemia oral manifestations 4
Definition
oral infection
pharyngitis
tonsillitis
neck cellulities (ludqigs angina)
Term
monocytic leukemia oral manifestations 1
Definition
leukemic infiltration of the gingivate and peridonitis
Term
what diseases could malaontic pigmentation of the oral cavity be 4
Definition
addisons disease
hemochromatosis
albright: fibrous dysplasia of bone
peutz jegher: GI polyposis
Term
oral manifestation of phenytoin
Definition
fibrous enlargement of gingivae
Term
oral manifestations of rendu-oslet-weber syndrome 2 and locations 6
Definition
AD disease
anrurysm telangiectases
mucosa of lral cavity, lips, GI tract, respiratory tract, urinary tract, internal viscera
Term
hairy leukoplakia: cause 3
Definition
EBV or HPV infects immune compormised (esp HIV) and causes hyperplasia of squamous mucosa (no dysplasia)
Term
hairy leukoplakia: location, appearance, association
Definition
white confluent patches, fluffy hypertonic thickening, that cannot be scraped off
on lateral border of tongue
often superimposed with thrush
Term
define leukoplakia
Definition
white plaque that cannot be scraped off
Term
4 causes of leukoplakia 4
Definition
lichen planus
candidiasis
irritation
premalignant to SCC (via tobacco)
Term
define erythroplakia
Definition
red velvety plaque (dysplastic leukoplakia) that cannot be scraped off
Term
how does a erythroplakia form
Definition
atypical epithelial changes with high risk of malignant transformation
Term
epidemology and causes 3 of erythroplakia
Definition
mostly male 40-70yo
tobacco, alcohol, HPB
Term
dx and tx of erythroplakia
Definition
need to biopsy always
persistant avoidance of irritant
Term
what type of cancer is most oral cancer
Definition
95% SCC
5% adenocarcinoma
Term
cause of oral SCC 6
Definition
tobacco, HPV, actinic radiation, pipe smoking, genetics, alcohol
Term
where does HPV infect and lead to oral SCC
Definition
tonsilar crypts and back of tongue
Term
what 3 mutations is oral SCC associated with
Definition
TP53, T63, NOTCH1
Term
where is oral SCC located 6
Definition
floor of mouth, ventral tongue, gingivia, lower lip, soft palate
Term
what does a oral SCC look like
Definition
raised, firm, pearly, rough, verrucous mucosal thickening
leukoplakia or erythroplakia on black background
ulcerate as they enlarge and get rolled borders
Term
what are the stages of oral SCC from least to most serious 8
Definition
hyperplasia
hyperkeratosis
mild
moderate dysplasia
severe dysplasia
CIS
SCC
metastasis: cervical nodes, mediastinal, lungs, liver
Term
prognosis of oral SCC 4
Definition
better if caused by HPV than if not
50% survive because it is usually diagnosed at advanced stage
50% die due to secondary primary tumor
35% change oc field cancerization
Term
what is field cancerization
Definition
elevated risk of additional primary tumors due to chronic mucosal exposure to carcinogens (alcohol, tobacco)
Term
5 inflammations of the nose
Definition
infectious rhinitis - common cold
allergic rhinitis - hay fever
nasal polyps
chronic rhinitis
sinusitis
Term
causes of infectious rhinitis 3
Definition
adenovirus
echovirus
rhinovirus
Term
signs of infectious rhinitis 4
Definition
cararrhal discharge
edematous nasal mucosa
pharyngotonsilitis
clears in 1wk
Term
complications of infectious rhinitis 5
Definition
secondary bacterial infection: staph, strep, H. influenza
otitis media
sinusitis
Term
cause of allergic rhinitis
Definition
IgE mediated reaction fo allergen (fingi, pollen, animal)
Term
signs of allergic rhinitis 5
Definition
mucosa, edema, erythema, mucous secretion, eosinophilic infiltrate
Term
associations with allergic rhinitis 3
Definition
asthma, eczema, nasal polyps
Term
nasal polups causes 3
Definition
recurrent rhinitis causes mucosa protrusion
cystic fibrosis
asthma intolerant asthma
Term
signs of nasal polup 4
Definition
polyp
possible ulceration
possible infection
large and may block airway or sinus
Term
chronic rhinitis: cause 2
Definition
repeated attack of rhinitis with superimposed bacterail infection
Term
signs of chronic rhinitis 3
Definition
ulceration or desqumation of mucosa
inflammatory infiltrate
may extend into sinuses
Term
causes of acute sinusitis 2
Definition
acute/chronic rhinitis
nonspecific inflammatory reaction
Term
signs of acute sinusitis
Definition
impairs sinus drainage causing empyema of sinusis
Term
complications of acute sinusitis
Definition
chronic sinusitis
Term
cause of chronic sinusitis 2
Definition
mixed microbial flora of mouth
fungi (mucormycosis in DM)
Term
signs of chronic sinusitis 2
Definition
sinusitis
spread to orbit or cranial structures
Term
3 necrotizing lesions of the nose and upper airway
Definition
spreading fungal infections
wegner granulomatosis
extranodal NK/T cell lymphoma (lethal midline granuloma)
Term
2 inflammations of the nasopharynx
Definition
pharyngitis
tonsillitis
Term
cause of pharyngitis/tonsillitis 10
Definition
virus: rhinovirus, echovirus, adenovirus, RSV, influenza, cosackie A, EBV
bacteria: GBS, B-hemolytic strep, staph aureus
Term
who gets pharyngitis/tonsillitis 4
Definition
compormised
neutropenic
diabetic
small children
Term
morphology changes in pharyngitis/tonsillitis
Definition
erythema and edema of pharyngeal mucosa
pseudomembrane: covered in exudate membrane
tonsils: enlarged, covered with pseudomembrane
Term
signs of pharyngitis/tonsillitis
Definition
sore throat
Term
complications of strep pharyngitis/tonsillitis 6
Definition
rheumatic fever
glomerulonephritis
peritonsillar abscess
tonsilitis, hyperemia, exudates
Term
complications of adenovirus pharyngitis/tonsillitis 3
Definition
tonsilitis, hyperemia, exudates
Term
complications of cosackie A pharyngitis/tonsillitis
Definition
hyperangina: pharynx vesicles and ulcers
Term
5 tumors of the nose/sinus/nasopharynx
Definition
nasopharyngeal angiofibroma
inverted papilloma
isolated plasmacytoma
olfactory neuroblastoma
nasopharyngeal carcinoma
Term
nasopharyngeal carcinoma: epidemology, mirphology, signs
Definition
adolescent males
benign tumor, fibrous and vascular
profuse epistaxis due to large vessels
Term
inverted papilloma: morphology, location 2, complications 2
Definition
locally agressive, grows into mucosa, squamous epithelium
nose and paranasal sinuses
can invade orbit and cranial vault
Term
isolated plasmacytoma: morphology, complications, tx
Definition
solitary myaloma
recurs and invades orbit and cranial vault
excision is curative
Term
olfactory neuroblastoma: morphology
Definition
malignant proliferation of neuroendocrine cells in olfactory mucosa
Term
nasopharyngeal carcinoma: epidemology
Definition
distinct geographical location
higher in chinese
Term
cause of nasopharyngeal carcinoma
Definition
EBV + genetic susceptability and age
Term
pathogenesis of nasopharyngeal carcinoma
Definition
EBV replicates in nasopharyngeal epithelium then infects B cells which induce T cell proliferation making atypical T cells and lymphocytes

when combined with genetic susceptability it transforms nasopharyngeal cells
Term
signs of nasopharyngeal carcinoma
Definition
large cervical nodes
Term
histological varients of nasopharyngeal carcinoma, which is most linked to EBV
Definition
keratinizing squamous cell carcinom
nonkeratinizing squamous cell carcinoma
undifferentiated carcinoma - most linked to EBV
Term
appearance of a nasopharyngeal carcinoma 4
Definition
large epithelial cells
indistinct borders (synctal growth in nests)
surrounded by mature lymphocytes
eosinophilic nuclei
Term
prognosis of nasopharyngeal carcinoma
Definition
locally invasive, spread to cervical nodes
metastasis to distant sites
radiosensitive
5y survival 10%
Term
define laryngitis
Definition
inflammation of larynx
Term
cause of laryngitis 4
Definition
allergy, virus, bacteria, tobacco`
Term
4 types of laryngitis
Definition
laryngoepiglottitis
laryngotracheobronchitis
TB laryngitis
diptheria laryngitis
Term
laryngoepiglottitis: cause 2, signs 6
Definition
H. influenza or GBC cause inflammation of epiglottis

medical emergency: sudden swelling of epiglottis or vocal cords, drooling, dysphagia, muffled voice, inspiratory stridor, airway obstruction
Term
laryngotracheobronchitis: cause 2, signs 3
Definition
parainfluenza or RSV causes inflammatory narrowing of airway
inspiratory stridor, hoarse barking gough, possible respiratory failure
Term
TB laryngitis cause
Definition
cough up infectious particles that infect larynx
Term
diptheria laryngitis: cause, morphology
Definition
implants on airway and releases toxin causing pseudomembrane (necrosis, fibropurulent gray dirty exudate
Term
diptheria laryngitis complications 3
Definition
aspiration: due to sloughing of pseudomembrane
myocarditis
peripheral neuropathy
Term
benign lesions of the larynx 3
Definition
vocal cord nodules (polyps)
laryngeal papilloma/squamous papilloma
recurrent respiratory papilomatosis
Term
causes of vocal cord nodules 2
Definition
heavy smoking
singers nodes (chronic irritation)
Term
location of vocal cord nodules
Definition
on true vocal cords
Term
symptoms of vocal cord nodules 2
Definition
impingement of cord
change in vouce (progressive hoarsness)
Term
morphology of vocal cord nodules 6
Definition
smooth
hemisphericle
<0.5cm
fibrosis
stratified squamous
degenerative mycoid CT
Term
laryngeal papilloma / squamous papilloma cause 2
Definition
HPB 6 and 8
Term
location of laryngeal papilloma / squamous papilloma 3
Definition
true vocal cords
single in adult
multiple in kids (juvenile laryngeal papilloma)
Term
morphology of laryngeal papilloma / squamous papilloma 6
Definition
soft
raspberry like
<1cm
finger like projections
fibrovascular cord
stratified squamous
Term
complications of laryngeal papilloma / squamous papilloma
Definition
when on free edge trauma causes ulceration and hemoptysis, benign, frequently reoccur
Term
recurrent respiratory papillomatosis differences in epidemology
Definition
adults: single lesion
children: reoccur after excision, more common
Term
recurrent respiratory papillomatosis cause 6
Definition
HPV 6 and 11 usually vertical transmission
Term
recurrent respiratory papillomatosis prognosis
Definition
benign, regress around puberty
Term
laryngeal carcinoma: epidemology
Definition
>4yo M>W
Term
laryngeal carcinoma: causes 4
Definition
smoking, alcohol, asbestos, HPV
Term
laryngeal carcinoma locations 6 and their prevalences
Definition
glottis (on vocal cord) 60%
supraglottic 25%
subglottic 5%
epiglottic
aryepiglottic fold
piriform sinuses
Term
laryngeal carcinoma type of cancer
Definition
95% SCC
rare adenocarcinoma from mucous glands
Term
laryngeal carcinoma morphological stages
Definition
1. in situ: pearly gray, wrinkled plaque on mucosa surface

2. ulcerating and fingating, invasive, atypical epithelium
- glottis tumors: keratinized, well differentaed
Term
how is the malignant potential of a laryngeal carcinoma determined
Definition
spectrum of epithelial adhesions (hyperplasia to invasive carcinoma) and thickness of lesion
Term
laryngeal carcinoma clinical signs 9
Definition
hoarsness: in glottis location this comes earlier due to interferance
cough, stridor, pain, dysphagia, hemoptysis, intrinsic/extrinsic larynx relaxation
increased risk for infection and ulceration
Term
prognosis of laryngeal carcinoma - general
Definition
metastasis rare due to sparse larynx lymph supply
1/3 die, 2/3 cured from surgery or radiation
Term
prognosis of laryngeal carcinoma - supraglottic
Definition
has more lymph supply and is more likley to metastasize to cervical nodes
Term
prognosis of laryngeal carcinoma - glottic
Definition
often confined to larynx and have better prognosis
Term
prognosis of laryngeal carcinoma - subglottic
Definition
usually manifest as advanced disease
Term
3 inflammations of the ear
Definition
otitis media
cholesteatomas
otosclerosis
Term
acute otitis media: epidemology, causes 4
Definition
infects infants and young kids
viruses
bacteria: H. influenza, S. pneumo, M. catarahalis
Term
how do you tell viral and bacterial otitis media apart
Definition
viral: serous exudate
bacterial: suppurative exudate
Term
cause of chronic otitis media 3
Definition
pseudomonas aeruginosa: in DM causes necrotizing otitis media
staph aureus
fungi
Term
signs of chroninc ottis media 3
Definition
eardrum performation
spread to mastoid
spread to cranial vault
Term
cause of cholesteatomas
Definition
cystic lesion with amorphous squamous debris
not neoplasms, dont need to have cholesterol
Term
signs of cholesteatomas
Definition
progressive enlargement erodes structures of inner ear causing visible nect mass
Term
otosclerosis cause
Definition
abnormal bonr deposition in middle ear at rim of oval window where footplate of stapes fits
Term
signs of otosclerosis 3
Definition
bilateral
familial
ankylosis of structures causing hearing loss
Term
what is the most common tumor of the ear, who is it seen in, why
Definition
SCC of the pinna
elderly men
actinic radiation
Term
complications of SCC of the external canal
Definition
invade cavity or metastasize to nodes
Term
3 neck masses
Definition
branchial cyst (lymphoepithelial cyst)
thyroglossal tract cyst
paraganglioma (carotid body tumor)
Term
branchyial cyst: cause
Definition
benign mass in ANTEROLATERAL NECK that came from branchial arch element or developmental salivary gland inclusion within cervical nodes
Term
branchyial cyst prognosis
Definition
rarley cancerous
cured with excition
can cause similar lesions on parotid or under tongue
Term
thyroglossal tract cyst: cause
Definition
embrylogically in thyroid anlage (regional of foramen cecum)
developing gland descends to normal position in anterior neck
remnants of tract persist causing cysts that may have lymphoid aggregates or thyroid tissue
Term
thyroglossal tract cyst: prognosis
Definition
incomplete excision may allow for reoccurence
Term
paraganglioma cause
Definition
cluster of neuroendocrine cells connected with sympathetic NS
tumors at arenal medulla give rise to pheochromocytomas
tumors in extra adrenal paraganglia make paragangliomas
Term
sigs of a paraganglioma located by paravertebral ganglia 3
Definition
have sympathetic connections
chromaffin positive
some make catecholamines
Term
paraganglioma by the great vessels (carotid body tumor): epidemology, cause/associations
Definition
innervated by PANS, sense O2 and CO2 (chemodctomas)

sporatic, show in 60s, assicuated with multiple endocrine syndeome
Term
paraganglioma by the great vessels (carotid body tumor): prognosis
Definition
50% fatal due to infiltrative growth
Term
what are the 4 salivary glands
Definition
major: parotid, submandibular, sublingual
minor: numerous around mouth
Term
xerostoma: pathogenesis
Definition
dry mouth due to decreased saliva production, may occur with atrophy, ulcerations, fissures of tongue
Term
xerostoma: complications 3
Definition
atrophy, ulcerations, fissures of tongue
Term
xerostoma: causes 3
Definition
sjogern's syndrome: inflammation of salivary glands, dry eyes, dry vagina
radiation
druge induced
Term
what is the most common inflammatory lesion of the salivary gland
Definition
mucocele
Term
mucocele: cause
Definition
blockage or rupture of duct with saliva leaking into stroma
Term
mucocele: appearance
Definition
fluctuant swelling of lower lip that may change in size, associated with meals
Term
mucocele morphology
Definition
cyst like space, granulation tissue or fibrous CT
filled with mucin and macrophages
Term
mucocele tx
Definition
excision of cyst and minor gland is curative
Term
saladenitis causes 4
Definition
bacteria: S. aureus, S. viridans
autoimmune: sjogern syndrome
viral: mumps
Term
what is the most common viral saladenitis
Definition
mumps
Term
what are the 3 locations of mumps activites and what does it do there
Definition
parotid: bl interstitial inflammation and mononuclear infiltrate

pancrease: increases serum amylase

testes: causes orchitis and sterality when pt >10yo
Term
locations of bacterial sialadenitis
Definition
major glands, esp submandibular
Term
cause of bacterial saladenitis
Definition
obstruction via caliculi/salioltiasis, food, injury, phenothiazine, therapy, dehydration
Term
what is the most common cause of bacteial saladenitis in the elderly
Definition
dehydration leads to bacterial protiditis following thoracic or abdominal surgery due to non specific inflammation of the glands
Term
signs of pyogenic bacterial saladenitis 2
Definition
suppurative necrosis and abscess, unilateral
Term
signs of bacterial saladenitis 2
Definition
painful enlargement
purulent ductal discharge
Term
location and prevalence of salivary gland neoplasms
Definition
65-80% in parotid
10% in submandibular
rest in minor/sublingual
Term
location and prevalence of malignant salivary gland neoplasms
Definition
90% sublingual
10% submandibular
15% parotid
inversley proportional to gland size
Term
epidemology of salivary gland neoplasms
Definition
older adults 50-60yo
female usually
Term
benign salivary gland tumors 6
Definition
pleomorphic adenoma
warthrin tumor (papillary cystadenoma lymphomastosum)
oncocytoma
basal cell adenoma
canicular adenoma
ductal papilloma
Term
malignant salivary gland tumors 6
Definition
mucoepidermoid carcinoma
adenocarcinoma
acinic cell carcinoma
adenoid cystic carcinoma
malignant mixed tumor
SCC
Term
pleomorphic adenoma: location and prevalence
Definition
60% parotid
rest submandibular or buccal
Term
cause and morphology of pleomorphic adenoma
Definition
PLAG1 rerangement
mature ductal gland epithelial and mesenchymal differentiation
matrix: myxoid, hayline, chondroid stroma (cartalginous), osseous
Term
cellular arrangement patterns of pleomorphic adenoma 5
Definition
ducts
acini
irregular tubules
strands
sheets
Term
signs of pleomorphic adenoma
Definition
painless: no invaded facial nerve because NOT MALIGNANT
Term
appearance of pleomorphic adenoma
Definition
slow, discrete mass, round, encapsulated, gray-white-blue, mobile
Term
signs of a parotid pleomorphic adenoma
Definition
swelling in front and below ear
Term
prognosis of pleomorphic adenoma
Definition
long term malignancies not common (identified when pt begins to have facial nerve damage

reoccur after 4% of parotidectomies and 25% enucleation

carcinoma arises within tumor sometimes (carcinoma ex pleomorphic adenoma)
Term
what is the second most common salivary neoplasm
Definition
warthin tumor
Term
warthin tumor: 2 risk factors
Definition
mostly in males
8x risk in smoker
Term
warthin tumor: location 3
Definition
almost always in parotid
10% multifacial
10% bilateral
Term
morphology warthin tumor
Definition
cystic tumor
lymph tissue: embryologically common in parotid because it is last gland to separate from adjacent stroma
Term
what is the most common primary malignant salivary gland tumor
Definition
mucoepidermoid carcinoma
Term
mucoepidermoid carcinoma cause
Definition
usually radiation induced rerangement in MAML2 or NOTCH pathway
Term
mucoepidermoid carcinoma location
Definition
promoditly in parotid gland
Term
mucoepidermoid carcinoma cellular composition 3
Definition
squamous cells
mucous secreting cells
intermediate cells
Term
mucoepidermoid carcinoma appearance
Definition
up to 8cm
circumscribed
no capsule
infiltrative
pale gray
mucinous
Term
mucoepidermoid carcinoma cellular patterns
Definition
cords, sheets, cyst linked with squamous, mucinous, or intermediate cells
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