Term
| The two NTs that primary sensory afferents use: |
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Definition
|
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Term
| Pain treatment options for inflammatory pain |
|
Definition
|
|
Term
| Pain treatment options for neuropathic pain: |
|
Definition
TCAs
Anticonvulsants
Na+ channel blockers
NMDA receptor antagonists
Opioids |
|
|
Term
Evaluating pain in infants using
CRIES |
|
Definition
Crying
Requiring 95% oxygenation
Increased vital signs (HR,BP)
Expression
Sleeplessness |
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|
Term
| Aspririn, acetaminophen, ibuprofen, naproxen, fenoprofen are: |
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Definition
|
|
Term
| Etodoloac, piroxicam, meloxicam are: |
|
Definition
| Relatively selective COX 1,2 inhibitors |
|
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Term
|
Definition
| COX 2 inhibitor (fewer GI side effects) |
|
|
Term
| COX 1 inhibitors decrease ________and cause __________ and ____________. |
|
Definition
thromboxanes
platelet aggregation
vasoconstriction |
|
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Term
| COX 2 inhibitors decrease __________ and cause ____________. |
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Definition
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|
Term
What is:
-a narcotic-like (partial mu agonist)drug and
-a NE and 5HT uptake blocker
-with low dependence liability
-useful for mild to moderate pain |
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Definition
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Term
| Name some anti-epileptic drugs for Neuropathic pain |
|
Definition
1) Gabapentin (first choice w proven efficacy)
2) carbamazepine - for trigeminal neuralgia
3) Lamotrigine
4) Topiramate
5) Pregabalin |
|
|
Term
| Name some antidepressants approved as adjuvants for pain therapy: |
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Definition
(they inhibit NE and 5HT uptake; NE most effective)
-Amitriptyline (drug of choice)
-Desipramine
-Duloxetine
-Imipramine |
|
|
Term
| Targeting antinociception: use |
|
Definition
NSAIDS
Local anesthetics
Opiates |
|
|
Term
| Treating inflammatory pain: use |
|
Definition
NSAIDS
Opiates tho NSAIDS better |
|
|
Term
| Treating Neuropathic pain via preventing sensitization: use |
|
Definition
|
|
Term
| Treating Neuropathic pain via blocking sensitized neurons: use |
|
Definition
Local anesthetics
Opiates (tho not ideal)
Anti-epilepsy drugs
Antidepressants & alpha 2 agonists (increase NE and 5HT synaptically, which help suppress nociceptive input)
(NSAIDs won't work anymore!) |
|
|
Term
| Mild to moderate pain: use |
|
Definition
NSAIDS: acetaminophen, ibuprofen, naproxen, ketorolac, celecoxib
Narcotics: tramadol, hydrocodone |
|
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Term
| Moderate to severe pain: use |
|
Definition
Narcotics: oxycodone, morphine, hydromorphone, fentanyl, methadone, meperidine
Local anesthetics: lidocaine |
|
|
Term
|
Definition
Lorazepam (a benzodiazepine)
Noradrenergic antidepressants
Antiepilepsy drugs |
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|
