Term
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Definition
| Helps reduce the level of renal injury in some cancer patients treated with platinum based therapies and/or radiation |
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Definition
| Used to decrease cardiac events in cancer patients exposed to anthracycline therapy |
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Definition
| Used to rescue "normal" cells after exposure to methotrexate |
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Term
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Definition
| Used to decrease bladder irritation (hemorrhagic cystitis) caused by ifosfamide or cyclofosfamide |
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Term
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Definition
| Used to protect kidneys from renal injury |
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Term
| Daunorubicin cumulative lifetime dose |
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Definition
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Term
| Doxorubicin cumulative lifetime dose |
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Definition
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Term
| What is the name for a cancer of the bloodstream or bone marrow? |
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Definition
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Term
| What is the name for a cancer of lymphatic tissue? |
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Definition
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Term
| Busulfan is used at high doses as an agent to prepare patients for BMT. What is a significant adverse effect that requires prophylaxis for these patients? |
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Definition
| tonic-clonic seizures - prophylaxis with an anticonvulsant |
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Term
| Irinotecan is a topoisomerase I inhibitor known to cause significant diarrhea. According to the textbook chapter, what are ways to treat this diarrhea? |
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Definition
Acute diarrhea during infusion can be treated with atropine.
Delayed diarrhea is treated with loperamide 2mg every 2hrs until diarrhea has stopped x 12 hrs. |
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Term
| What are common types of cancer that are described as carcinomas |
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Definition
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Term
| This drug is a pro-drug for 5-fluorouracil (5-FU). |
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Definition
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Term
| Mucositis is a common adverse effect for this drug. Oral mucositis may be reduced if the patient uses ice chips in the mouth for 30 minutes after a bolus of this medication. |
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Definition
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Term
| What tissues are commonly considered to be the origins for cancers labeled sarcoma? |
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Definition
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Term
| This drug is potentially fatal if given via the intrathecal route. |
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Definition
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Term
| When given with allopurinol the dose of this agent must be reduced by 66-75%. |
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Definition
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Term
| When using this agent at high doses eye irritation must be prevented with the use of around-the-clock ocular steroid administration. |
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Definition
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Term
| Palmar-plantar erythrodysesthesia is a potential adverse effect seen with these agents. What is the name of one of these drugs? |
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Definition
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Term
| This alkylating agent is known to have an acrolein metabolite, and can causes hemorrhagic cystitis. At high doses it is recommended that patients receive the chemo-protective agent Mesna in addition to IV hydration. |
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Definition
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Term
| This platinum based agent is known for the ability to produce a cold-induced neuropathy. |
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Definition
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Term
| This glycopeptide can produce significant pulmonary toxicity. |
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Definition
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Term
| Dose of Bleomycin that, if exceeded, can result in pulmonary toxicity |
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Definition
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Term
| Name a common adverse reaction seen with interferon therapy? Pretreatment with acetaminophen may reduce this complication. |
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Definition
| Flu-like syndrome/symptoms |
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Term
| This immune therapy can cause serious adverse effects when given IV due to vascular leakage of the agent. |
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Definition
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Term
| This agent is a member of the alkylating class and requires use of the chemo-protective agent Mesna in addition to IV hydration to prevent hemorrhagic cystitis. |
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Definition
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Term
| Use of topical corticosteroids can reverse the antitumor effects of this immune therapy. |
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Definition
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Term
| Use of this monoclonal antibody can lead to significant GI toxicity, including a perforated bowel. |
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Definition
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Term
| Trastuzumab targets the HER2 receptor that is over expressed in some patients with breast cancer (25-30%). What adverse effect can occur with use of this agent, especially when used in combination with an anthracycline? |
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Definition
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Term
| This form of chemotherapy is given prior to the surgical procedure. |
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Definition
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Term
| This form of chemotherapy approach is given in an effort to destroy any left-over cancer cells that may be present after the known tumor is removed by surgery. |
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Definition
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Term
| Provide me with the name of one chemotherapy agent that can produce a bowel obstruction. |
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Definition
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Term
| What agents should be used as a pre-treatment when using paclitaxel? |
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Definition
| Dexamethasone, Diphenhydramine, H2 Blockers - Hypersensitivity rxn |
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Term
| What special issue is there for patients with ascites or an effusion that should be considered prior to methotrexate therapy? |
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Definition
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Term
| The enzyme based chemotherapy agent can cause allergic reactions and can deplete fibrinogen. |
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Definition
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Term
| This chemotherapy agent is primarily excreted via the kidney. It is associated with significant hypokalemia and hypomagnesemia, and aggressive hydration is necessary to prevent damage to the kidneys. If that is not enough, this drug is also highly emetogenic and can cause ototoxicity. |
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Definition
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Term
| Patients will likely experience urine that is blue-green with this anthracycline. |
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Definition
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Term
| Liposomal doxorubicin is generally less toxic than regular doxorubicin. What adverse effect is specific to the liposomal dosage form? |
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Definition
| Palmar-plantar Erythrodysesthesia |
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Term
| A patient previously on daunorubicin is being considered for a new regimen that involves mitoxantrone. What is the cumulative dose limit for mitoxantrone for this patient? |
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Definition
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Term
| This monoclonal antibody has been known to cause severe infusion reactions and severe and prolonged immunosuppression requiring prophylaxis. |
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Definition
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