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organogenesis/ sex determination
Organogenesis and Sex Determination
35
Biology
Undergraduate 4
04/29/2014

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Term
intermediate mesoderm
Definition
precursor of kidneys and gonads
Term
nephron
Definition
the functional unit of the kidney
Term
pronephros
Definition
tubules of the initial kidney
Term
mesonephros
Definition
second tubules derived caudally from the nephric duct which are the sources of hematopoietic stem cells and eventually form the epididymis and vas deferens
Term
metanephros
Definition
becomes the final kidney and forms caudally from the mesonephros
Term
metanephrogenic mesenchyme  
Definition
intermediate mesoderm which committed to forming the kidney and induces ureteric buds
Term
ureteric buds (easy to misspell!)
Definition
branches induced by the metanephrogenic mesenchyme from the Nephric duct which become the collecting ducts and ureters that transport urine to the bladder.  They induce mesenchyme to condense and differentiate into the nephrons
Term
polycystic kidney disease
Definition
kidney disease caused by cysts within the kidney
Term
somatic (parietal) mesoderm
Definition
the dorsal layer of the lateral mesoderm closest to the ectoderm
Term
splanchnic (visceral) mesoderm
Definition
the ventral layer of the lateral mesoderm
Term
atrium (atria)
Definition

 

derived from the 2nd heart field, the 2 chambers which receive blood from the body

 

Term
ventricle
Definition
 chamber of heart which expels blood to the body
Term
myocardium
Definition
splanchnic mesoderm  becomes cardiomyocytes which forms the musculature of the heart
Term
pericardium
Definition
outer portion of heart, the sac, derived from mesoderm
Term
cardiogenic mesoderm -
Definition
cells which migrate to the lateral mesoderm which are the precursors to the heart
Term
heart field
Definition
region of cardiogenic mesoderm which becomes the heart
Term
endocardial tubes
Definition
after neurulation precursors (cardiogenic mesoderm) delaminate and undergo an epithelium to mesenchymal transition and reassemble into small tubes
Term
heart tube
Definition
the fusion of the 2 heart fields create this tube, becomes the ventricles
Term
cardiac looping
Definition
the turning of the heart tube to bring the atria to a dorsal anterior position to the ventricles
Term
chamber ballooning
Definition
Term
endoocardial cushions
Definition
cells which make the valves
Term
cardiac septation -
Definition
septum formation which divide chambers of heart.
Term
cardia bifida -
Definition
cardiac precursors do not migrate to midline and create inviable
Term
vasculogenesis
Definition
initial formation of blood vessels initiated by fgf2
Term
hemangioblast
Definition
precursors of blood and blood vessels, derived from cells from the primitive streak
Term
angioblasts
Definition
progenitors of endothelial cells forming the lining of blood vessels
Term
hematopoietic stem cells
Definition
progenitors of blood cells
Term
primary capillary plexus
Definition

 

the intially formed group of capillaries at a blood islands or around an organ

 

Term
VEGF (vascular endothelial growth factor)
Definition
promotes angiogenesis
Term
angiopoietins
Definition
mediate the interaction between the endothelial cells and the smooth muscle cells that the endothelial cells recruit to cover them
Term
angiogenesis -
Definition
the process of sprouting new branches of vessels that occurs throughout the life of the organism
Term
artery
Definition
contain ephrin b2 on cell membranes allowing the fusion to veins only at border regions and with arteries at nonborder regions
Term
vein
Definition
contain eph b4, the receptor for ephrin b2
Term
anti-angiogenesis compound -
Definition
compounds which inhibit vegf reception and inhibit angiogenesis in regions such as the cornea
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