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Opt 631 Exam 1 Corneal Degenerations
Dr Yudcovitch Lecture 1
37
Medical
Graduate
09/03/2011

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Term
What is a dysgenesis?
Definition
congenital malformation
Term
What is dystrophy?
Definition
A hereditary pattern
Term
What is a degeneration?
Definition
Breakdown due to possibly age or systemic dz; may involve inflammatory process
Term
What is an involutional corneal degeneration?
Definition
common, age related corneal degeneration such as pinguecula, arcus, Hassle-Henle bodies, etc.
Term
What is a non-involutional corneal degeneration?
Definition
related to local or systemic conditions, less common. E.g. pterygium, band keratopathy, amyloid degeneration
Term
What is arcus?
Definition
An asymptomatic, very common age related deposition of cholesterol.
Term
What is the tx for arcus?
Definition
None unless seen in pt's under 40, then refer for med exam/lipid profile
Term
What is the a Limbal Girdle of Vogt?
Definition
Asymptomatic, narrow, white opacity on nasal and temporal limbus area. Seen in pt's older than 45.
Term
What is the pathology of a Limbal Girdle of Vogt?
Definition
collagen fiber degeneration
Term
What is a dellen?
Definition
thinning of cornea, usually near limbus. Caused by dryness. May be symptomatic
Term
What is the tx for a dellen?
Definition
lubrication, therapeutic SCL
Term
What are Hassall-Henle bodies?
Definition
small, round thickenings of Descemet's membrane --> endothelial displacement. Located in periphery. If central = guttata.
Term
What is the tx for Hassle-Henle bodies?
Definition
none. May be sign of corneal
Term
What is a Pellucid Marginal Degeneration?
Definition
inferior corneal thinning that may lead to decreased VA's. Similar to keratoconus
Term
What is the tx for Pellucid Marginal Degeneration?
Definition
correct cylinder with gas permable CL, keratoplasty may be necessary
Term
What is Terriens Marginal Degeneration?
Definition
marginal stromal thinning leading to marginal opacification and neovascularization. May have lipid border; minor trauma can cause rupture
Term
What is the tx for Terrien's Marginal Degeneration?
Definition
Steriods, keratoplasty
Term
What is a Marginal or Furrow Degeneration?
Definition
bilateral thinning seen adjacent to arcus
Term
What are the causes of Marginal or Furrow Degeneration?
Definition
systemic dz such as SLE, leukemia, TB, polyarteritis nodosa
Term
What is Mooren's ulcer?
Definition
serpiginous limbal ulceration due to autoimmune rxn. Two types, one in older, one in younger pt's
Term
What is tx for Mooren's ulcer?
Definition
Responds poorly, steroids may speed perforation. Refer to corneal specialist for reconstruction/excision
Term
What is Posterior Crocodile Shagreen?
Definition
small, gray polygonal patches in descemet's membrane.
Term
What is the DDX and tx for Posterior Crocodile Shagreen?
Definition
rule out other more serious conditions, otherwise, none.
Term
What is amyloid degeneration?
Definition
Degeneration of Bowman's and epithelium. Secondary to long standing dz.
Term
What is the tx for amyloid degeneration?
Definition
keratectomy or corneal transplant
Term
What is Coats White Ring?
Definition
white ring in cornea due to previous trauma (foreign body, etc). May contain iron
Term
What is band keratopathy?
Definition
interpalpebral fissure calium deposits in Bowman's and anterior stroma.
Term
What causes band keratopathy?
Definition
hypercalcemia, chronic uveitis, autoimmune dz
Term
What is the tx for band keratopathy?
Definition
lubrication, chelating agents, or just scrape off.
Term
What is a bullous keratopathy?
Definition
An acute and painful bubbling of the cornea due to fluid buildup under epithelium caused by long term corneal edema. Will eventually scar.
Term
What is the tx for bullous keratopathy?
Definition
Anti-edema tx, early stages --> SCL; late stages have poor prognosis
Term
What is Salzmann's Nodular Degeneration?
Definition
multiple, bluish white nodules at mid-periphery. Often indicates phlyctenular dz.
Term
What is the tx for Salzmann's Nodular Degeneration?
Definition
If asymptomatic, monitor. Use AB's and CL's w/epithelial breakdown. Keratoplasty if necessary
Term
What is xerophthalmia?
Definition
A Vit A deficiency that leads to atrophy of conj. Goblet cells.
Term
What is keratomalacia?
Definition
acute corneal tissue liquefaction due to Vit A deficiency.
Term
What is the tx for Xerophthalmia?
Definition
Vit A supplementation
Term
What is the tx for keratomalacia?
Definition
Vit A supplementation
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