Term
| What size dose of ASA is required to prophylactically decrease the incidence of TIA, unstable angina in men as well as coronary artery thrombosis? |
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Definition
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Term
| What is the only salicylate that does not cross the blood brain barrier or the placenta? |
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Definition
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Term
| At low doses (2 300mg ASA) salicylates exhibit ______ activity. Only at higher doses do (12-20 300mg) does ASA produce both _______ and _______. |
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Definition
1. analgesic 2. analgesic and anti-inflammatory |
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Term
What dose of salicylate is required to reduce the incidence of myocardial infarction and to decrease the mortality in post myocardial patients? |
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Definition
| 2-160 mg tablets ASA q 2 days |
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Term
| It appears that ASA 160 to 325 mg/day is beneficial in the prevention of the first _______ in men over the age of ____ years. |
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Definition
1. myocardial infarction 2. 50 |
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Term
| At low doses salicylate is hydrolyzed by ______ to salicylate and ______ ____ in the blood and tissues. |
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Definition
1. esterases 2. acetic acid |
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Term
| The _____ metabolizes salicylate to _____ ______ ______ which is filtered by the kidneys. |
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Definition
1. liver 2. water soluble conjugates |
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Term
| What causes the serum half life of salicylate to increase from 3.5 hrs. to 15 hrs. when the dose >> 4 gm/day? How long does this take? |
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Definition
| The liver enzymes become saturated and zero order kinetics come into play. This takes several days to 1 week. |
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Term
| At low doses of salicylate uric acid secretion is ______. At high doses of salicylate, uric acid secretion is ______. |
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Definition
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Term
| _____ ______ is almost universal in patients treated with salicylates. |
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Definition
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Term
| The most common side effects of salicylates are _____, _____, and _____ |
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Definition
- epigastric distress
- nausea
- vomitting
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Term
| Toxic doses repress respiration resulting in respiratory and metabolic ______. |
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Definition
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Term
Should ASA be taken with food? |
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Definition
| Yes, ASA should be taken with food or large volumes of liquids. |
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Term
| What do toxic doses of salicylate do to body temperature? |
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Definition
| In toxic doses salicylates produce hyperthermia. Salicylates uncouple oxidative phophorylation. The resulting energy for the production of ATP is given off as heat. |
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Term
| ASA administered to children during _____ infections has been associated with an increase in the incidence of ____ syndrome, and often fatal _______ _______ with _______ edema. _______ should be ministered instead of ASA. |
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Definition
1. viral 2. Reye's 3. fulminating hepatitis 4. cerebral 5. Acetaminophen |
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Term
| Antacids ______ the rate of absoprtion of aspirin. |
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Definition
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Term
| _____ and ______ decrease the rate of urate excretion when combined with salicylate and hence are CI in gout |
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Definition
1. Probenecid 2. Sulfpyrazone |
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Term
| What seven drugs interact with salicylate to increase the therapeutic effect, half life, and toxicity? |
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Definition
1. Bilirubin 2. Phenytoin 3. Naproxen 4. sulfpyrazone 5. thyroxine 6. triiodothyronine 7. thiopental TTT SBPNS |
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Term
| What are the seven symptoms of severe salicylate intoxication? |
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Definition
1. Restlessness 2. Delirium 3. Hallucinations 4. Convulsions 5. Coma 6. Respiratory and metabolic acidosis 7. Death from respiratory failure |
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