Term
| What is the site of action of each of the protein Synthesis Inhibitors? |
|
Definition
Aminoglycosides: 30S(16S)
Tetracyclines: 30S (16S)
Lincosamines: 50S(Peptidyl Transferase)
Macrolides: 50S (23S)
Chloramphenicol: 50S (23S Peptidyl Trans)
Streptogramins: 50S (23S)
Oxazolidinones: 50S (23S Unique site) |
|
|
Term
| What is the spectrum for Tetracycline |
|
Definition
Burgdorferi
Pestis
Pallidium
Pyloris
Anthracis |
|
|
Term
| What are the Aminoglycosides and which ones is Pseudomonas resistant to? |
|
Definition
Gentamycin
Tobramycin
Streptomycin
Amikacin
Resistance: Genta>Tobra>Aminka |
|
|
Term
| What are the adverse effects of Aminoglycosides |
|
Definition
Nephrotoxicity
Neurotoxicity-Irreversible Ototoxicity
NMB |
|
|
Term
| What is the adverse effects of Lincosamines |
|
Definition
| Pseudomembranous colitis (C.diff) |
|
|
Term
| When is a D test preformed and what does it test for? |
|
Definition
When a cultured organism is Erythromycin-Resistant and Clindamycin-Sensitive
Prevent treatment with clindamycin to a resistant organism that appears to be suseptible |
|
|
Term
| What protein synthesis inhibitor antibotics can only be administered orally and which can only be administered by IV? |
|
Definition
Ketolides: Oral Only
Aminoglycosides and Streptogramins: IV only |
|
|
Term
| What are the lincosamines |
|
Definition
|
|
Term
| What are the Macrolides and what are the adverse effects |
|
Definition
Erythromyin
Clarithromycin
Azithomycin
Erythro and Clarithro (p450 elimination) |
|
|
Term
| What are the common Tetracyclines and What are their adverse effects |
|
Definition
Minocycline
Tetracycline
Doxycycline
Demeclocycline
Adverse: Tooth Discoloration
Photosensitivity
Anacid/Milk decreases absoption
|
|
|
Term
| What is Demeclocycline used for |
|
Definition
|
|
Term
| What are the adverse effects of Chloramphenicol |
|
Definition
Gray Baby Syndrome bc Hepatically cleared
Marrow Suppression: Reversible or Irreversible
P450 Clearance |
|
|
Term
| Which protein synthesis inhibitor anti-biotic is cleared by hepatic conjugation |
|
Definition
|
|
Term
| What are the adverse effects of Streptogramins |
|
Definition
Phlebitis
Myaglia
Hepatotoxic
P450 |
|
|
Term
| What are the streptogramins |
|
Definition
Dalfopristin
Quinupristin |
|
|
Term
| What are the Oxazolidinones |
|
Definition
|
|
Term
| What are the only protein synthesis inhibitors that are cidal |
|
Definition
Aminoglycosides: cause misreading
Streptogrammins: Strep, MSSA, MRSA
Oxazolidinones: Cidal versus strep only |
|
|
Term
| What are the adverse effects of Oxazolidinones |
|
Definition
Mono-Oxidase Inhibition-> Serotonin Syndrome
Myelosupression(Thrombocytopenia) |
|
|
Term
| What protein synthesis inhibitors are effective against MRSA |
|
Definition
Tigecycline
Streptogramins
Oxazolidinones
|
|
|
Term
| Which protein synthesis inhibitors are effective against VRE |
|
Definition
Tigecycline
Chloramphenicol
Oxazolidinones
|
|
|
Term
| Are aminoglycosides effective against GPC |
|
Definition
| Yes, only if used with a Cell Wall Inhibitor |
|
|
Term
| What is the mechanisms of resistance for each of the protein Synthesis Inhibitors |
|
Definition
Aminoglycosides: enzymes, permeability, altered target
Macrolides: Altered target, Efflux
Lincoamides: Altered target
Streptogramins: Altered Target
Oxazolidonones: Altered Target
Tetracycline: Efflux
Chloramphenicol: Enzymatic |
|
|
Term
| What protein synthesis inhibitors are effective against Staph and Strep? |
|
Definition
Lincosamines
Tetracycline
Chloramphenicol
Streptogramins
Oxazolidinones |
|
|
Term
| What is the advantage of ketolides over macrolides |
|
Definition
| Better against Strep pneumonia |
|
|
Term
| What antibiotics are useful against H.pylori |
|
Definition
Aminopenicillins
Clarithromycin: Macrolide
Tetracyclines |
|
|
Term
| What anti-biotic is effective against C. difficil |
|
Definition
|
|
Term
| What antibiotics are cleared by the the p450 system |
|
Definition
Macrolides
Chloramphenicol
Streptogramins |
|
|
Term
| Why are Macrolides not used to treat UTI's |
|
Definition
|
|
Term
| What is the drug of choice for Community Aquired MRSA |
|
Definition
|
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