Term
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Definition
| Loss of cell-cell adhesion |
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Term
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Definition
| increase in thickness of the epidermis; regular or irregular |
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Term
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Definition
| Keratinocytes are pink, shrunken |
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Term
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Definition
| “in-toeing” of the rete ridges (Lengthening) |
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Term
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Definition
| decrease in thickness of the epidermis |
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Term
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Definition
| Intracellular edema and disrupted attachments causing Epidermal destruction |
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Term
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Definition
| Apocrine secretion where part of the apocrine cell “pinches off” and is released into the lumen of the gland |
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Term
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Definition
| intercellular edema and eosinophis in the epidermis |
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Term
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Definition
| Familial disease with unusual blistering and skin color changes |
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Term
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Definition
| Lymphocytes migrating into epidermis in Cutaneous T-Cell Lymphoma |
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Term
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Definition
| loss of a portion of the epidermis; ulcer is loss of the entire epidermis |
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Term
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Definition
Fusion of cells together usually in response to chronic inflammation
Types: epidermal multinuc, touton, langhans, foreign body, osteoclastic, oncoyctic (pink & granular cytoplasm) |
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Term
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Definition
keratinocytes with clear cytoplasm and shrunken nuclei
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Term
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Definition
| WBC Breakdown: fragmentation of neutrophils(dust) |
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Term
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Definition
Types: Munro's- neutrophils in the horn in psoriasis
Spongiform pustules of Kogoj-multilocular pustules stratum spinosum
Pautrier's-3 or more atypical monocytes within the epidermis in mycosis fungoides |
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Term
| Psoriasis: Gross and Micro |
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Definition
Gross: Red and White scaly patches
Micro: Hyperkeratosis/parakeratosis w/ epidermal neutrophils
Thin epidermis over dermal papillae
Vessels close to the epidermis
Elongated rete ridges |
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Term
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Definition
Gross: Blisters/severe itching in elderly from IgG to BM
Micro: Subepidermal bullae with eosinophils
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Term
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Definition
Gross: Itchy/recurrent grouped blisters on extensor surfaces
IgA in dermal papillae/gluten-sensitive enteropathy
Micro: subepidermal blisters w/abscesses of neutrophils in tips of dermal papillae
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Term
| Pemphigus: Gross and Micro |
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Definition
Gross: Fragile blisters spread/produce by pressure or blunt trauma
Start in oral mucosa
30-60 of Mediterranean descent
Micro: Suprabasal acantholysis
Sparse lymphocytes infiltrates below blister
Blister roof has cohesively keratinocytes |
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Term
| Seborrheic keratosis: Gross, Micro and What can it be a sign of |
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Definition
Gross: Velvety, greasy,“stuck on” squamous growth
Micro: Keratinocyte proliferation with pseudohorn cysts
Leser-Trelat sign: multiple SKs and internal malignancy |
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Term
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Definition
Papillomatosis with parakeratosis at tips(“tiered”)
Koliocytes(epithelial cells w/ hyperchromasia, enlarged nuclei, and perinuclear halo)
Dilated dermal BVs in stratum corneum(blood in the horn)
Cells w/large keratohyalin granules in a vacuolated cytoplasm |
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Term
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Definition
Gross: Small/firm brown nodule on the lower extremities in females
Micro: Epidermal actinic hyperplasia
Dermis shows storiform fibrohistiocytic cells with thickened, collagen bundles surrounding
Deep penetrating subtype involves Subcut |
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Term
| Benign melanocytic lesions |
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Definition
Degenerative changes: fatty infiltration, angiomatoid degeneration, neurotization, balloon cell degeneration
Express a reasonable degree of maturation: cells decrease in size and become more spindly w/descent |
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Term
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Definition
Gross: scaling erythematous papules/plaques in sun-damaged skin
Occasional “cutaneous horn” formation
Micro: Solar elastosis (basophilic collagen breakdown)
Solar keratoses: Basal atypical keratinocytes with hyper/parakeratosis above |
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Term
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Definition
Micro: Square cell growth throughout epidermis lacking surface maturation (SCC in situ)
Malignant: extension into reticular dermis
Rare metastasis |
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Term
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Definition
Gross: flat/dome-shaped/ulcerated, pearly, telangiectasia lesion in sundamaged hair-bearing skin
Micro: Aggregated of undifferentiated basaloid cells Palisading with attachments to epidermis |
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Term
| Gross/Micro and determining Prognosis of Melanoma |
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Definition
Pronosis: thickness of lesion (Breslow’s Level)
Gross: ABCDs=Asymmetrical, Border irreg, Color variation (pink, brown, gray & blue), large Diameter (> 6 or 7mm) on sun exposed areas
Micro: Melanocyte nests w/ variable size/shape/spacing
“Pagetoid” upward migration of melanocytes
Necrosis, mitoses, ulceration |
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