Term
| What signs of SLE used in diagnosis and what population typically gets it |
|
Definition
Women<40
Arthritis
Serositis
Malar Rash
Discoid rash
Photosensitivity
Oral Ulcers
Renal
Neuological
Hematologic
Immunologic
ANA |
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Term
| What are some mucocutaneous lesions seen in Lupus |
|
Definition
Rashes: Malar, Discoid, Subacute Cutaneous
Ulcers
Alopecia
Vasculitic: Nailfold Infarct, Digital ulcer
Livedo Reticularis |
|
|
Term
| Describe the arthritis typical of lupus |
|
Definition
MCP/IP and Wrist Joints
Non-erosive
Ligament Loosening (Jaccoud's Arthritis) |
|
|
Term
| WHO Classification of of Renal Lupus and which is most common |
|
Definition
I) Normal light, but IG and Complement Deposits
II) Mesangial
III)Mild Focal
IV)Diffuse Proliferative (*Most Common)
V) Membranous
VI)Interstitial and Tubular (sclerosing) |
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|
Term
| What are the cardiopulmonary manifestations of Lupus? |
|
Definition
Accelerated Atherosclerosis
Pulm: Fibrosis, HPTN, "Shrinking lung Syndrome", Embolism, Effusion
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Term
| Antibodies against Ro(SSA), La(SSB), Smith protein, Anti-histone all produce what pattern on ANA analysis and what patients are each associated with |
|
Definition
Speckled pattern
Ro and La-Neonatal Lupus
Smith-Specific for Lupus
Anti-histone-Drug Induced Lupus |
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Term
| What are the possible pathogenic mechanisms of Lupus? |
|
Definition
Genetic
Impair Apototic Cell Removal
Breakdown of Self-Tolerance |
|
|
Term
| What protocols should you follow to best manage a lupus patient |
|
Definition
Photoprotection
Monitor every3-6 months
Prevent Atherosclerosis and Osteoporosis
Control Infections
Plan Preganancies
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|
|
Term
| When are high dose steroids used in the treatment of Lupus |
|
Definition
Acute Pneumonitis
CNS Symptoms
Thrombocytopenia
Hemolytic Anemia
Severe Nephritis |
|
|
Term
| What are the treatment options for lupus? |
|
Definition
Steroids
Steroid sparing agents
Biologicals
Cyclophosphamide-for steroid resistant lupus |
|
|
Term
| What is the fetal manifestations of a mother with Antiplatelet, anti-WBC, Anti-RBC, Anti-phospholipid, or Anti-Ro/La Antibodies |
|
Definition
Platelet-Thrombocytopenia
WBC- leukopenia
RBC-Fetal Loss
Phospholipid-Cutaneous
Ro/La-Heart block |
|
|
Term
| What are the pregnancy safe drugs for lupus |
|
Definition
Predisone
Sulfasalazine
Hydroxychloroquine |
|
|
Term
| What genetic defect is associated with lupus |
|
Definition
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