Term
| What is the most common cause of vasculitis |
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Definition
| Isolated cutaneous vasculitis from a drug rxn |
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Term
| Who is most likely to get Giant Cell Arteritis, Takayasu's Arteritis, and Polyarteritis Nodosa |
|
Definition
Giant Cell: Caucasian Women over 65
Takayasu's: Young Asian Women
Polyarteritis Nodosa: Men
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Term
| What vessel's are affected by Giant Cell Arteritis, Takayasu's, Polyarteritis nodosa, Wegner's Granulomatosis |
|
Definition
Temporal: Large Extracranials arteries with elastic lamina
Takayasu's: Aortic Branches
Polyarteritis Nodosa: Large and Medium, multisystem
Wegener's: Lung/URT, Renal
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Term
| What are the treatments for Giant Cell, Polyarteritis nodosa, and Wegener's |
|
Definition
Giant: High does Steroids until sed rate decreases
Polyarteritis: steroids + cyclophosphamide
Wegener's: steroids + cyclophosphamide |
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Term
| What is the standard diagnostic work up for a vasculitis? |
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Definition
Vascular biopsy
Assess which organs
Assess vessel size and the presence of elastic lamina |
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Term
| What are some signs of giant cell arteritis and how is the diagnosis made |
|
Definition
Temporal Headaches
ESR
Blindness
Polymyalgia Rheumatica
DX: Temporal Biopsy |
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Term
| What are the signs of Polyarteritis nodosa |
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Definition
| Multisystem ischemia: Bowel, Skin Mononeuritis Multiplex, Renal |
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Term
| What are some mimics of Vasculitis |
|
Definition
Endocarditis
Atrial Myxoma
Cholesterol Embolism
Thromboangiitis obliterans |
|
|
Term
| How do you diagnose Wegener's Granulomatosis |
|
Definition
| Granulomatous inflamation on vessel biopsy |
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|
Term
| What is the typical presentation and work up for Inflammatory Muscle Diseases? |
|
Definition
Proximal Muscle Weakness
Skin(if dermatomyositis): Rash of Sun-exposed areas, periungual telengeictasias, Heliotrope, Calcinosis
Work Up: Increased Muscle Enzymes
Abnormal EMG
Abnormal Biopsy
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|
|
Term
| What are the skin lesions associated with dermatomyositis |
|
Definition
Photosensitive Rash
Periungual Telangiectasias
Heliotropic eyelids
Gottron's Papules (over Knuckles) |
|
|
Term
| What endocrine test should you never forget to run on a patient who is suspected to have Inflammatory Muscle disease |
|
Definition
| TSH, Hypothyroid can mimic it |
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Term
| What are the components of CREST syndrome |
|
Definition
Calcinosis
Raynaud's
Esophogeal Dysmotility
Sclerodactyly
Telangiectasias |
|
|
Term
| What serious complications are seen in diffuse scleroderma, but not in CREST syndrome? What severe complication is shared? |
|
Definition
Diffuse: Polymyositis
Renal Failure
Lung(HPTN, Fibrosis)
Severe Diverticulosis
Shared: Pulmonary HPTN |
|
|
Term
| What areas of the body are first affected by scleroderma? |
|
Definition
|
|
Term
| What malignancy is Sjogren's syndrome associated with? |
|
Definition
| Lymphoma as is Rheumatoid Arthritis |
|
|
Term
| What antibodies are associated with sjogrens's syndrome and how is the diagnosis made |
|
Definition
SSA or SSB
Biopsy of minor lib salivary gland |
|
|
Term
| What symptoms are shared by primary and secondary sjogren's syndromes? |
|
Definition
Keratoconunctivitis Sicca
Xerostoma |
|
|
Term
| Do scleroderma patients typically have a positive ANA? |
|
Definition
| 90 % Do have it, Yeah, Yeah, Yeah!(3x's) Hey, look it's Chris Brown! |
|
|
Term
| What is used to treat pulm hypertension in CREST syndrome to prevent RHF? |
|
Definition
| Endothelial-1 Receptor Blockers |
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