Sepsis

DIC

SIADH

SCC

Hypercalcemia

Superior Vena Cava Syndrome

Tumor Lysis Syndrome

Caused by tumor w/in spinal cord or vertebrae collapse fm tumor degradation of bone

Back pain may occur prior to nerve deficit

Often metastatic tumor

Tx includes high dose corticosteroids, radiation, surgery, and/or external braces

• Occurs most often with bone metastasis
• Bone CA causes release of Ca into bloodstream
• Lung, head and neck, kidney or lymph node CA secretes parathyroid hormone - causes bone to release Ca
• Decreased mobility and dehydration = exacerbate hypercalcemia
• Oral hydration may be only tx needed
• Life-threatening hypercalcemia - dialysis temp.

• Suppression or obstruction by tumor or clots
• Painful & life-threatening
• Blockage of venous return from head, neck and upper trunk
• Early manifestations upon awakening = facial edema and collar tightness
• Progression = engorged vessels/ erythema of upper body
• Late manifestations = hemorrhage, cyanosis, AMS, decreased CO, hypotension
• Tx = metal stent (may become compressed also)

• Increase of cells being destroyed = K and purines released
• Hyperkalemia and hyperuricemia
• Hydration!!!  - 3-5 L of fluid day before, of and after treatment
• May need antiemetics, diuretics, and purine excretion promoters
• Dialysis/IV meds if severe