Term
|
Definition
PDGF-B chain GF
overexpression
Astrocytoma, osteosarcoma |
|
|
Term
|
Definition
Fibroblast GF
overexpression
Stomach cancer |
|
|
Term
|
Definition
Fibroblast GF
amplification
Bladder cancer, breast cancer, melanoma |
|
|
Term
|
Definition
TGF-a GF
overexpression
Astrocytoma, hepatocellular carcinoma |
|
|
Term
|
Definition
HGF
overexpression
Thyroid cancer |
|
|
Term
|
Definition
EGF-receptor family
overexpression
SCC of lung, gliomas |
|
|
Term
|
Definition
FMS-like tyrosine kinase 3 (GF receptor)
amplification
Breast and ovarian cancers |
|
|
Term
|
Definition
Receptor for neurotrophic factors
point mutation
Leukemia
Multiple endocrine neoplasia 2A and B
Familial medullary thyroid carcinomas |
|
|
Term
|
Definition
PDGF Receptor
overexpression, translocation
Gliomas, leukemias |
|
|
Term
|
Definition
Receptor for stem cell (steel) factor
point mutation
GI stromal tumors, seminomas, leukemias |
|
|
Term
|
Definition
GTP-binding (protein in signal transduction)
point mutation
colon, lung, pancreatic tumors |
|
|
Term
|
Definition
GTP-binding (protein in signal transduction)
point mutation
Bladder and kidney tumors |
|
|
Term
|
Definition
GTP-binding (protein in signal transduction)
point mutation
Melanomas, hematologic malignancies |
|
|
Term
|
Definition
Nonreceptor tyrosine kinase (protein in signal transduction)
translocation
Chronic myeloid leukemia
Acute lymphoblastic leukemia |
|
|
Term
|
Definition
RAS signal transduction
point mutation
Melanomas |
|
|
Term
|
Definition
WNT signal transduction
point mutation, overexpressed
Hepatoblastomas, hepatocellular carcinoma |
|
|
Term
|
Definition
Transcriptional activator (nuclear reg. protein)
translocation
Burkitt lymphoma |
|
|
Term
|
Definition
Transcriptional activator (nuclear reg. protein)
amplification
Neuroblastoma, small-cell carcinoma of lung |
|
|
Term
|
Definition
Transcriptional activator (nuclear reg. protein)
amplification
Small-cell carcinoma of lung |
|
|
Term
|
Definition
Cyclin, cell cycle regulator
Translocation: Mantle cell lymphoma
Amplification: Breast & esophageal cancers |
|
|
Term
|
Definition
cyclin cell cycle regulator
overexpression
Breast cancer |
|
|
Term
|
Definition
Cyclin-dependent kinase, cell cycle regulator
amplification or point mutation
Glioblastoma, melanoma, sarcoma |
|
|
