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Oncogenes and tumor suppressor genes
Oncogenes and tumor suppressor genes and their associated tumors
20
Medical
Graduate
04/12/2011
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Term
abl
 Definition
CML; Philadelphia chromosome, t(9:22)
Term
c-myc
 Definition
Burkitt’s lymphoma
Term
bcl-2
 Definition
Follicular and undifferentiated lymphomas
Term
erb-B2
 Definition
Breast, ovarian, and gastric carcinomas
Term
ras
 Definition
Colon carcinoma
Term
L-myc
 Definition
Lung tumor
Term
N-myc
 Definition
Neuroblastoma
Term
ret
 Definition
MEN 2A and 2B
Term
c-kit
 Definition
Gastrointestinal stromal tumor
Term
Rb
 Definition
Retinoblastoma, osteosarcoma
Term
BRCA1
 Definition
Breast and ovarian cancer
Term
BRCA2
 Definition
Breast cancer
Term
p53
 Definition
Many human cancers, Li-Fraumeni syndrome
Term
p16
 Definition
Melanoma
Term
APC
 Definition
Colorectal cancer associated with FAP
Term
WT1
 Definition
Wilms’ tumor
Term
NF1
 Definition
Neurofibromatosis type 1
Term
NF2
 Definition
Neurofibromatosis type 2
Term
DPC
 Definition
Pancreatic cancer
Term
DCC
 Definition
Colon cancer
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