Term
|
Definition
chronic, multi-system inflamm disease
production of a variety of auto-antibodies
women 9x>men
ages 15-45
^ in AAs, hispanics, asians |
|
|
Term
| Clinical criteria for lupus |
|
Definition
Malar Rash
Serositis
Discoid Rash
Photosensitivity
Oral ulcers
Neurologic Symptoms
Arthritis
Immunologic disorder
Hematologic Disorders
Antinuclear Antibody
Renal disorder |
|
|
Term
| mucocutaneous manifestations of lupus |
|
Definition
photosensitivity
rashes: butterfly (spares nasolabial folds), discoid, subacute cutaneous-raised erythematous lesions (SCLE)
oral/nasopharyngeal ulcers (usually painless)
vasculitic lesions: nailfold infarcts, frank digital ulcers
alopecia (discoid scarring)
livedo reticularis |
|
|
Term
|
Definition
arthralgias: MCP/IP and wrist joints
NO erosions |
|
|
Term
| renal manifestations of lupus |
|
Definition
persistent proteinuria
cellular casts
nephrotic syndrome
ESRD |
|
|
Term
|
Definition
cognitive disorder
headaches
depression, psychosis
seizures
stroke/TIA
aseptic meningitis
mono/polyneuropathy |
|
|
Term
|
Definition
accelerated atehrosclerosis
pleuropericarditis/effusions
pneumonitis
intersititial fibrosis
pulm HT
myocarditis/valve disease
pulm embolism |
|
|
Term
|
Definition
anemia
leukopenia
thrombocyopenia
lymphopenia
lymphadenopathy
splenomegaly
hemalytic anemia |
|
|
Term
|
Definition
| antidsDNA and anti-smith: high diagnostic specificity |
|
|
Term
|
Definition
acute: >1mg/kg prednisone, then taper
life-threatening: pulse steroids 1g/day
"steroid sparing" agents: hydroxycholorquine, methotrexate, azathipprine, leflunomide, MMF
Biologicals: rituximab
cyclophosphamide: standard for steroid-resistant SLE |
|
|
Term
| How is steroid-resistant SLE treated? |
|
Definition
|
|
Term
| What manifestations warrent high dose steroid therapy? |
|
Definition
severe lupus nephritis
CNS lupus
autoimmune thrombocytopenia
autoimmune hemolytic anemia
acute pneumonitis |
|
|
Term
| Common causes of death in lupus patients |
|
Definition
infections
lupus nephritis
renal failure
CV disease
CNS lupus |
|
|
