Term
| AA with seborrheic keratosis on the face |
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Definition
| dermatosis papulosa nigra (AD) |
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Term
| elderly man with mutiple brown-black keratotic papules w/"stuck on" appearance on his face, trunk, extremities |
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Definition
|
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Term
| What is an inherited (AD) benign skin lesion? |
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Definition
| dermatosis papulosa nigra |
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Term
| benign skin lesions w/malignant potential |
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Definition
| actinic keratosis, keratocanthoma |
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Term
a light-skinned individual with scaly red macules on sun-exposed areas
may form a thick scale (cutaneous horn)
may be tender |
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Definition
|
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Term
| What is seen microscopically in actinic keratosis? |
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Definition
buds of atypical keratinocytes eminating from undersurface of epidermis
2-12% risk of progression to sq cell carcinoma
tx: liquid nitrogen |
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Term
|
Definition
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|
Term
| single or multiple crateiform papules or nodules w/central keratoic plug; rapid growth to 2cm then regresses w/scarring |
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Definition
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Term
| non-melanoma skin cancers |
|
Definition
basal cell carcinoma
squamous cell carcinoma |
|
|
Term
| What is the most common skin cancer? |
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Definition
|
|
Term
| What are the risks for basal cell carcinoma? |
|
Definition
skin pigmentation
early sun-exposure
genetic factors |
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|
Term
|
Definition
|
|
Term
| What are predisposing factors to sq cell carcinoma? |
|
Definition
chronic inflamm
actinic keratosis
actinic cheilitis |
|
|
Term
| causes of sq cell carcinoma |
|
Definition
extrinsic: UV light, ionizing radiation, chemical carcinogens, HPV
intrinsic: genetic syndromes, chronic immunosuppression, genetic tendency, positive family history |
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Term
|
Definition
small to large pigmented lesion (increased risk of melanoma in proportion to size)
often hairy |
|
|
Term
| familial atypical ole syndrome |
|
Definition
familial condition w/many bizarre nevi
melanoma arises in nearly all members |
|
|
Term
| What is the most frequent cancer in women 25-29 years old? |
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Definition
|
|
Term
| What are some risk factors for malignant melanoma? |
|
Definition
red/blonde hair
blue/green eyes
fair complex
Family Hx of MM
actinic keratoses
marked freckling on upper back
blistering sunburns prior to age 20
outdoor summer job before age 20
numerous moles, frequently atypical
intermittent sun exposure |
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Term
|
Definition
arises from malignant clone of melanocytes at D-E junction
most arise from resident cells, some in pre-existing nevi
intraepidermal growth phase within epidermis and adnexal epithelium (melanoma in situ)
invasive: invades dermis
metastases via lymph or hematogenously |
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|
Term
| What is the most common type of malignant melanoma, and where is it found? |
|
Definition
superficial spreading melanoma
trunk and limbs
back of men
posterior legs of women |
|
|
Term
|
Definition
slowly expanding, irregular, hyperpigmented patch followed by tumor invasion
sun damaged skin of elderly patients |
|
|
Term
| acral lentigenous melanoma |
|
Definition
acral skin (palm, soles, digits, mucous membranes)
increased in AA, hispanic, oriental races |
|
|
Term
| Why does subungal malignant melanoma have a poorer prognosis? |
|
Definition
| because it has an increased depth at time of diagnosis |
|
|
Term
|
Definition
Asymmetrical
irreg Border
Color variation
Diam > 6cm
Evolving |
|
|
Term
| primary tumor characteristics that are of prognostic significance |
|
Definition
thickness (breslow's level)
ulceration
level of invasion
age
anatomic site
gender |
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