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Ocular Disease
Ocular disease
69
Biology
Graduate
01/28/2013

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Term
Blepharospasm
Definition
Benign Essential blepharospasm
Involuntary
Femals
6th decade

Tx Botulinum toxin every few weeks
Term
blepharoclonus
Definition
Excess blinking with subsequent spasm
Occurs SECONDARY to ocular inflammation
Term
Myokymia
Definition
Fasiculations of the orbicularis
Typically unilateral and self-limited

CC: jumping or quivering of the lid or eye

Cause: Fatigue, Stress, Medication, Alcohol

Management: Cool compresses Topical antihisatmines

GOAL: Prolong the muscle refractory period

OTC remedy Tonic water i contains quinine
Term
Pseuodgraefe
Definition
Aberrant Regeneration
Due to trauma to the 9rd nerve

MR fibers run to the LPS
Elevation when the eye is aDducted
Term
Marcus Gunn Phenomenon
Definition
AKA Jaw winking
Congenital ptosis cases
when patient opens mouth ptosis gets better.
TX: Surgery
Term
Angioedema with urticaria
Definition
Occurs secondary to histamine release
Histamine triggers massive vasodilation

Characterizedby severe swelling and may also see hives

Associated with itching

TX: Antihistamines, Cool compress, Steroids possibly.
Term
Cutaneous Anthrax
Definition
Wool Sorters Disease
Infection is via contact through break of skin.

You will see Preseptal Cellulitis

eschar, black to brown ulcer on lid
Term
Syphilis
Definition
Can have primary or secondary lid lesions

Eye signs: Conjunctival chancre, madarosis, scleritis, interstitial keratitis

Tx: Penicillin
Term
Elephantiasis
Definition
Parasitic infection
Characterized by hypertrophy of the lids and subcutaneous tissue

Severe edema occurs due to a surge of lymphatic fluid into the sub-q tissue

Severe allergic response to the parasite.
Term
Vaccinia
Definition
Mosst often secondary to a small pox vaccine. through direct contamination of the lid.

Can be used in warfare
Term
Leukoderma
Definition
White Skin
Term
Poliosis
Definition
White Lashes
Term
Vogt Koyanagi
Definition
An autoimmune response to the sun

Ocular Signs: Poliosis, uveitis, inflammatory RD
Other signs: Headache, encephalopathy, seizures, vitiligo, deafness.
Term
Xeroderma pigmentosa
Definition
Hereditary Autosomal Recessive syndrome

Sunlight exposure has progressive pigment changes to the skin MACULES AN SCARRING
Patients have increased risk of cancers, BCC,SCC,Melanoma, and conjunctibal malignancies
Term
Erysipelas
Definition
Swelling associated with a well-defined expanding red line

Skin trauma that is invaded by B hemolytic streptococcus

May lead to ectropion or entropion
Term
Erythema Multifome
AKA Stevens Johnson Syndrome
Definition
Severe type IV or delayed(DTH) hypersensitivity
Causative agents are typically medication Sulfa drugs, barbituates
Young Males
Iatrogenic

Flu-like symptomes
Severe rash with perivascular inflammation and bulls eye appearance

Ocular signs: mucous discharge, pseudomembrane formation, papillary response, bullae formation, swollen crusted lids.

Management:
Electrolytes, tears, bandage contact lens, lid taping

Topical systemic steroids in high doses to reduce inflammtion and scarring

Surgery may be necessary to decrease and correct scarring
Term
Ocular Cicatricial Pemphigoid
Definition
Auto-immune mucous membrane disorder in which bullae form in various mucous tissues and rupture causeing severe pain and scarring

Older Women

Similar to Eyrthema multifome

Keratinization of the cornea and conjunctiva
Term
Impetigo
Definition
Cause: Staph but infrequently strep
Children
Macular rash on lids and face with crusted over blister like lesions (bullae)
Treatment: Topical antibiotics
Term
HZV Herpes
Definition
Harbored in nerves
Frontal Nerve = lesions on upper lid and forehead and superior conj
Pthalmic division of CN V = HZO
Nasociliary involvement = Hutchinsons sign: Tip of nose involved

Tx: Oral Antivirals, acyclovir 800mg 5 times a day, topicals drying lotions, steroids, antihistamines, antidepressents, prednisone, analgesics
Term
Anophthalmos
Definition
Complete absence of ocular tissue in the orbit
Related to how the optic vesicle forms
Surgeon places solid conformer in eye
Term
Microphthalmos
Definition
Abnormal smallness of one or both eyes
Pure microophthalmos: Absence of all ocular defects
Nanophthalmos: Absence of ocular contents within the eye itself
Term
Craniosnostosis
Definition
Some or all the the sutures in the skull close too early in an infant
Main concern: Increase in intercranial pressure.
-Possible exophthalmos, Mesured from pt's zygomatic arch on each side.
Term
Scaphocephaly
Definition
Craniosynostosis
Premature fusion of the sagittal suture
Term
Trigonocephaly
Definition
Craniosynostosis
Premature fusion of metopic asuture or frontal suture
High retreating forehead. From above their forehead looks like a pyramid
Term
Brachycephaly
Definition
Craniosynostosis
Premature fusion of coronal suture
Flat-head syndrome
Shortened front to back diameter of skull
Term
Oxycephaly
Definition
Craniosynostosis
Premature closure of coronal and lambdoidal suture
Tower skull or high-head syndrome
Term
Plagiocephaly
Definition
Craniosynostosis
Premature closure of coronal or lambdoidal suture
flattening of back or side of head
oblique slant
Term
Hybertelorism
Definition
Increased distance between the eyes
cleft palate, nose and upper lip
Term
Orbital Dystopia
Definition
Vertical mal-alignment of the orbit (one eye is higher than the other)
Causes:
Congenital: Craniosynostosis, Orbital facial clefts
Acqured: Facial/orbital fractures, trauma, mass/tumors
Term
Orbital Dystopia
Definition
Vertical mal-alignment of the orbit (one eye is higher than the other)
Causes:
Congenital: Craniosynostosis, Orbital facial clefts
Acqured: Facial/orbital fractures, trauma, mass/tumors
Term
Crouzon's Syndrome
Definition
AD: Premature closure of cranial base sutures, orbit, and maxillary complex
Brachycephaly
Sightns/symptoms: Wide set bulging eyses, beaked nore, underdeveloped jaw, DENTAL problems (V shaped palates), Hearing loss, cleft lip/palate. Exophthalmos, Hypertelorism, V pattern exotropia, Aniridia, Blue sclera, Cataract, Ectopic lens, glaucome, megalocornea, optic nerve hypoplasia
Term
Apert's Syndrome
Definition
AD: Acrocephosyndactly: Brachycephaly and/or oxycephaly. Severe Symemetrical syndactyly of hands and feet.
Signs: proptosis, Hypertelorism, Exotropia, Corneal exposure, optic atrophy. High cleft palate, low set ears, organ anomalies, mentally handicapped.
Term
Mandibulofacial Dystosis
Definition
Treacher Collins OR Franceeshetti-Zwahlen-Klein Syndrome
Sighns: Hypoplasia of the zygomatic, maxilla & mandile bone
indistinct inferior orbital margin, Conductive hearing loss.
Coloboma: part of tissue is missing (of the eyelid), and ectropian
Term
Goldenhar's syndrome
Definition
Incomplete development of ear, nose, soft palate, lip, and mandible usually on ONE side of the face. 99% of organs will be underdeveloped on one side of the body. SColiosis of the spine. PREAURICULAR APPENDAGE( blobs of the tissue near the ear)
Lipodermoid, epibulbar dermoid cyst
Hearing loss
Term
Pierre-Robin Syndrome
Definition
Unusually small mandible (micrognathia)
Posterior displacement or retraction of the tounge. Upper airway obstruction, Cleft palate, "bird face" appearance
Term
Hallermanstrieff Syndrome
Definition
Dyscephaly, Dental anomalies, Structures are smaller, Hypotrichosis(not many eyelashes), Skin problems on head, bilateral congenital cataracts, Bilateral MICROHTHALMIA
Term
Meningocele
Definition
CSF CYST
Meninges protrude through orbit
Term
Encephalocele
Definition
Neural tube defect
Sac-like protursions of the brain and meninges
CSF AND GRAY MATTER
Exophthalmos, pulsating proptosis (NO BUITS)
Anterior Vs Posterior: Supero-medial orbit affected VS defect in sphenoid bone
Term
Mucocele
Definition
Cause: Sinus infection, Trauma, Allergies, Tumor.
Ethmoid: push eyes down
Ethmoid: Push eye out
Maxillary: Elevate and push in
Orbital: sphenoid compress optic nerve and vision loss
Symptoms: Older,l Vission loss, ephiphora, facial trauma or sinus disease.......
Term
Cyclopia
Definition
One Eye, One orbit, no vision, nose and nostrils missing
Term
Synopthalmos
Definition
Paired ocular strucres in one orbit
Failure of midline facial structure development, no nose
Term
Orbital Cellulitis
Definition
General inflammation/infection of the soft tissues of the orbit.
BEHIND the orbital septum, caused by SINUS NFECTION, orbital fracture, dental infection, orbital trauma, post surgical
Staphylococcus, streptococcus, or Haemophilus influenzae
Symptoms: Very sick, FEVER, malaise, headache, rhinorrhea, prulent nasal discharge, HASPITALIZATION, Swelling, RESTRICTED PAINFUL EYE MOVEMENTS, Dark red color
Raised IOP
DECREASED VA's
Tx: Referral out, IV antibiotics could be life threatening
Term
Preseptal Cellulitis
Definition
Infection ANTERIOR to ORBITAL septum.
2o to localized infections. Normal ocular movements/ normal EOMs
No exophthalmos
Little to no VA reduction
Small Fever, less pain the orbital cellulitus
Tx: Oral antibiotic AMOXOCILLIN 500mg PO TID
Term
Cavernous Sinus Thrombosis
Definition
Cavernous sinus that is filled with venous blood (behind the superior orbital fissures) CN 3,4,5, and 6, and carotid artery
2o to infection or trauma.
Very similar to orbital cellulitus but BILATERAL, Blue area behind ears, Cranial nerve signs, altered consciousness
Orbital Pain, Visual disturbances. Spreads via communicating veins, increased IOP, Can effect grey matter, seizures, unabler to stay awake.
Tx: Hospitalization: Broad spectrum IV antibiotics
Term
Orbital Pseudotumor
Definition
Idopathic orbital inflammatory disease.
2o to Syphilis,sarcoid, TB
Unilateral, middle age, ABRUPT PAINFUL ONSET(Tellate Sign)
Limitation of gaze, Exopthalmos, dry eye, Decreased VAs, diplopia
Tx: Oral prednisone 60-100 mg/qqd for 2-3 weeks. benign.
Term
Orbital Myositis
Definition
Orbital Pseudotubor that involves EOM's
Third most common orbital disorder
Unilateral and often younger adults
Proptosis, Chemosis
EOM limited movement
Term
Orbital Apex Syndrome
Definition
When Orbital pseudotumor effects the orbital apex
Pt presents: Pain proptosis, Vission loss, Defects with CN 3,4,5,6, +APD
Term
Intermittent Exophthalmos
Definition
Popping Eye syndrome
Non-pulsatile, no bruit
Eye being pushed out of socket
Varix: congenital enlargement of venous channels
Term
Pulsating Exophthalmos
Definition
Bulging, pulsating eye
Eye pops out of socket, with a pulse
Will hear Bruits
Rare and painful
2o to trauma, Caused by an arteriovenous aneurysm involving the ophthalmic or internal carotid artery
Term
Carotid Cavernous Fistula
Definition
Term
Graves
Definition
Term
Hyperthyroidism
Definition
Term
Hypothyroidism
Definition
Term
Superficial dermoid cyst
Definition
Term
Deep dermoid cyst
Definition
Term
Capillary Hemangioma
Definition
Term
Cavernous Hemangioma
Definition
Term
Rhabdomyosarcoma
Definition
Term
Enucleation
Definition
Removal of the eyeball orbital contents remain
Term
Evisceration
Definition
Remove entire contents of the globe leaving the scleral shell and sometimes cornea intact
Term
Exenteration
Definition
Entire removal of the orbital contents including eyebaall, EOM, fat and connective tissue.
Term
Orbital Emphysema
Definition
Term
Megalocornea
Definition
Term
Microcornea
Definition
Term
Sclerocornea
Definition
Term
Posterior Embryotoxon
Definition
Term
Axenfeld-Reiger's Syndrome
Definition
Term
Peter's Anomaly
Definition
Term
21
Definition
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