Term
| MC classification of ovarian CA: |
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Definition
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Term
| Serous cystoadenomcarcinoma is the MC __ __ of the ovary. It is __ most of the time and most are associated with extraovarian spread at the time of dx. This is seen mostly in __ women and has a __ prognosis. |
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Definition
- malignant tumor
- bilateral
- premenopausal women
- good |
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Term
| Mucinous neoplasms account for 10% of epithelial ovarian neoplasms. They have a __ __ __ test and are usually __. They are known for their __ __. |
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Definition
- positive Acid Schiff test
- UNILATERAL
- LARGE SIZE (up to 150lbs) |
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Term
| Endometroid nepolasms account for 10% of epithelial ovarian cancer. They have an __ patter that resembles __ __. This is usually ___. |
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Definition
- adenomatoid pattern
- endometrial adenocarcinoma
- bilateral |
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Term
| Clear cell CA aka __ __ of the ovaries resembles __ __ __. Has __ and __ cells. This may be associated with __ and __. __ acid schiff test. |
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Definition
- mesonephroid carcinoma
- renal cell carcinoma
- hobnail and clear cells
- hypercalcemia and hyperpyrexia
- negative acid-schiff test |
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Term
| Transitional Cell aka __ Carcinoma of the ovaries accounts for less than 1% of epithelial cell cancers and resembles a low grade __ __ __ of the __. This has a __ prognosis. |
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Definition
- Brenner carcinioma
- transitional cell CA of the bladder
- poor |
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Term
Epithelial Cell Ovarian CA:
- Serous cystoadenocarcinoma- bilateral
- Mucinous neoplasm- unilateral, positive acid-schiff
- Endometroid- bilateral
- Clear cell/Mesonephroid CA- hobnail and clear cells
- Transitional Cell/Brenner CA- poor prognosis |
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Definition
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Term
| Germ cell Neoplasms of Ovaries: |
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Definition
- Dysgerminoma
- Endodermal sinus tumor
- Dermoid cysts (aka germ cell neoplasms)
- Immature Teratomas
- Mature Teratomas
- Embryonic Carcinoma
- Choriocarcinoma
- Mixed Germ Cell tumors |
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Term
| A ____ is a germ cell neoplasm that is the female couterpart to the male seminoma. It is usually in __ females and accounts for 30-40% of germ cell tuors. It is __, __, __, and __ encapusulated with brown grayish color. It is usually ___. A ___ infiltrate is a favorable prognostic indicator. |
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Definition
- dysgerminoma
- young
- rubbery, smooth, round, and thinly encapsulated
- unilateral
- lymphocytic infiltrate |
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Term
| Endodermal sinus tumors aka __ __ __ are almost always ___. They are the most __ __ neoplasm that occurs at any site. These are friable, necrotic, and hemorrhagic and thus present with an __ __. The pathognomic finding is a __ __ body, which is a single papilla lined by tumor ells with a central blood vessel. |
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Definition
- yolk sack tumurs
- bilateral
- most rapidly growing neoplasm
- acute abdomen
- Schiller-Duval body |
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Term
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Definition
| pathognomic finding for Endodermal sinus tumor aka yolk sac tumor |
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Term
| Most rapidly growing neoplasm that occurs at any site: |
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Definition
| Endodermal sinus tumor aka yolk sac tumor |
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Term
| Are endodermal sinus tumors aka yolk sac tumors unilateral or bilateral? |
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Definition
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Term
| Are dysgerminomas unilateral or bilateral? |
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Definition
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Term
| Dermoid cysts aka germ cell neoplasms arise from germ cell elements of the ovary. These tend to occur in women in their __ and __ and have a __ __. |
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Definition
- 20s and 30s
- better prognosis |
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Term
| Epithelial cell ovarian CA tends to occur in women in their __, whereas dermoid cysts tend to occur in women in their __ and __. |
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Definition
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Term
| Immature teratomas are ___, whereas the great majority of mature teratomas are __. |
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Definition
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Term
| Immature teratomas are ___, usu in women in their __ and usually ___. Tissue is derived from the three germ layers. ___ bodies stain positive for __. |
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Definition
- malignant
- 20s
- unilateral
- Hyaline bodies stain positive for AFP (alpha feto protein?) |
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Term
| Mature teratomas are almost always __, occur in women in their __ and __, and are the most common neoplasm during __. May contain hair and teeth. |
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Definition
- benign
- 20s and 30s
- pregnancy |
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Term
| Embryonic Carcinoma is a very rare germ cell tumors with mean age of dx at __ y/o. There are __ __ of __ __ cells with __ __ ___ that appear to merge together. __ and __ are usually elevated. These tumors may produce __. |
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Definition
- 15 y/o
- large sheets of polygonal cells with pale eusinophilic cytoplasms
- hcg and AFP usually elevated
- estrogen |
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Term
| Solid sheets of large polygonal cells with pale eusinophilic cytoplasms. Elevated hcg and afp. |
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Definition
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Term
| Primary Ovarian Choriocarcinoma is a rare germ cell tumor unrelated to pregnancy (Gestation choriocarcinoma is related to pregnancy). What is the difference b/w these two? |
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Definition
| - primary ovarian choriocarcinoma has lower elevations of hcg than gestational choriocarcinoma does |
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Term
| Primary Ovarian Choriocarcinoma tumors often have endocrine activity that cause __ __, __ __, or ___. |
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Definition
- precocious puberty
- uterine bleeding
- amenorrhea |
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Term
| Primary ovarian choriocarcinoma (germ cell) is composed of ___, __ ____, and ___. |
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Definition
- cytotrophoblasts
- intermediate trophoblasts
- syncytiotrophoblasts |
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Term
| Ovarian neoplasm composed of cytotrophoblasts, intermediate trophoblasts, and syncytiotrophoblasts: |
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Definition
| Primary Ovarian Choriocarcinoma |
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Term
| Mixed germ cell ovarian tumors are often a combination of a __ and an __ __ __. |
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Definition
- dysgerminoma
- endodermal sinus tumor |
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Term
| Really rare ovarian tumor in premenarche girls that causes pseudopuberty. Embryoid bodies seen. |
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Definition
| Polyembryoma (germ cell mixed) |
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Term
| Germ cell ovarian tumors may elevate __, ___, or both. |
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Definition
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Term
| 3 types of ovarian cancers: |
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Definition
- Epithelial
- Germ cell
- Sex cord/stromal tumors |
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Term
| Sex cord/stromal CA of the ovary account for 5-8% of ovarian cancer. The most common type of stromal tumor being ___ ovarian tumors. |
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Definition
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Term
| Granulosa stromal ovarian tumors may cause ___ and __ __ in young girls or __ __ and __ __ in postmenopausal women. |
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Definition
- hyperestrogenism
- precocious puberty in young girls
- endometrial hyperplasia and vaginal bleeing in postmenopausal women |
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Term
| Sex cord/stromal ovarian tumors (mostly granulosa) are known by their __ or __ __ neuclei. You may see __ __ bodies. |
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Definition
- grooved or coffee bean nuclei
- Call-Exner bodies |
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Term
| two types of stromal tumors: |
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Definition
- granulosa
- sertoli stromal cell tumors |
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Term
| Types of ovarian tumors that may cause precocious puberty: |
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Definition
- Primary ovarian choriocarcinoma
- Polyembryoma
- Granulosa
- Sertoli |
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Term
| Neoplasms metastatic to the ovaries include: __ __, __, or __. ___ __ tumors are carcinomas of the stomach that mets to the ovary. |
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Definition
- genital tract
- breast
- GI
- Krukenburg |
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Term
| Danazol can be used as an alternative to GnRH analogs b/c Danazol does not cause osteoporosis. However, it does cause a worse __ __ and __ of the __. |
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Definition
- lipid profile
- deepening of the voice |
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Term
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Definition
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