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Nutrition: Chapter 12
Fat Soluble Vitamins
71
Biology
Undergraduate 2
03/15/2010

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Term
Fat Soluble Vitamins
Definition

Retinoids

Carotenoids

Vitamin D

Vitamin E

Vitamin K

Term
Where digestion of fat soluble vitamins begins....
Definition
Stomach
Term
Releases enzymes that help further release fat soluble vitamins.
Definition
Pancreas
Term
Most vitamin absorption takes place here...
Definition
Small Intestine
Term
Percentage of ingested fat-soluble vitamins that are absorbed...
Definition
40-90%
Term
How fat-soluble vitamins are transported in the body.
Definition
Chylomicrons and Lipoproteins via lymphatic circulation.
Term
Functions of Retinoids
Definition

FUNCTIONS:

Growth and Development

Vision

Immune Function

Dermatology

Term
Food sources of retinoids.
Definition

FOOD SOURCES:

Liver

Fish oils

Fortified Dairy

Eggs

Term
Percent of retinoids that are absorbed.
Definition
70-90%
Term
How retinoids are transported in body.
Definition
Bound to retinal binding proteins in lymphatic system.
Term
Functions of Carotenoids
Definition

FUNCTIONS:

Prevention of CVD

Cancer prevention

Age-related macular degeneration

Cataracts

Term
Hypercarotinemia
Definition
Skin turns yellow due to high intake of carotenoids.
Term
Food Sources of Carotenoids
Definition

FOOD SOURCES:

Dark green and yellow/orange fruits and vegetables.

Term
Enzymatic Conversion of Carotenoids
Definition
Carotenoids split into two molecules of retinoids: retinal and retinoic acid
Term
Location of Enzymatic Conversion
Definition
Liver or Intestines
Term
Provitamin A Carotenoids
Definition

Beta-carotene

Alpha Carotene

Beta-cryptoxanthin

Term
How carotenoids are transported in body.
Definition
VLDL
Term

Lutein

Lycopene

Zeaxanthin

Definition
Other carotenoids
Term
Vitamin A - RDA
Definition

Men = 900 micrograms

Women = 700 micrograms

Term

Vitamin A

Daily Value (DV)

Definition
1000 micrograms
Term

Vitamin A

Average Intake

Definition
meets DRI
Term
Vitamin A Deficiency
Definition

Night blindness

Decreased mucus production

Decreased immunity

Eye infections

Bitot's spots

Xeropthalmia

Blindness

Poor growth

follicular hyperkeratosis

Term
Acute Vitamin A Toxicity
Definition

Symptoms disappear when megadose stops:

 

GI effects

headache

blurred vision

poor muscle coordination

Term
Chronic Vitamin A Toxicity
Definition

Long term megadose, possibly permanent:

 

Bone/muscle pain

Loss of appetite

Skin disorders

Headache

Hair loss

Increased liver

Vomiting

Term
Functions of Vitamin D
Definition

FUNCTIONS:

Ca and P homeostasis

Regulation of Blood Ca levels

Cell differentiation

Immunity

Term
Food Sources of Vitamin D
Definition

FOOD SOURCES:

Fatty fish

Cod liver oil

Fortified Dairy and cereals

 

Term
Skin formation of Vitamin D3 (Steps)
Definition

1. Sunlight makes Provitamin D3 from 7-dehydrocholesterol.

 

2. Sunlight converts Provitamin D3 to Previtamin D3 in skin.

 

3. Previtamin D3 is converted to Vitamin D3 and released into the bloodstream.

Term
Vitamin that is known as a conditional or prohormone.
Definition
Vitamin D
Term
Absorption of Vitamin D2
Definition
80% incorporated into micelles and absorbed in SI
Term
Transportation of Vitamin D2
Definition
Via chylomicrons in lymphatic system to CV system, where it is bound to a protein.
Term
Transport of Vitamin D3
Definition
Processed in liver where it is inactivated and travels through blood for weeks before it is reactivated in kidneys.
Term
Vitamin D that is tightly regulated by the PTH and kidneys.
Definition
Vitamin D3
Term
Vitamin D Storage Site
Definition
Fat tissues
Term

Vitamin D

RDA

Definition
No RDA
Term

Vitamin D

Adequate Intake

Definition

Under 51 yrs = 5 micrograms/day

51-70 Yrs = 10 micrograms/day

Over 70 yrs = 15 micrograms/day

Term

Vitamin D

Daily Value

Definition
10 micrograms/day
Term

Vitamin D

Upper Limit

Definition
50 micrograms/day
Term
Vitamin D Toxicity
Definition

Occurs with supplementation:

Hypercalcemia

 

Term
Side effects of hypercalcemia
Definition

Calcium deposits in kidney, heart and blood vessels

Narrowing pulmonary arteries and aorta

Facial changes

Mental retardation

Term
Vitamin D Deficiency
Definition

Children: rickets

Adults (mostly women): osteomalacia

Term
Symptoms of Rickets
Definition

Weak, brittle bones

Bow leg and protruding belly

Term
Symptoms of Osteomalacia
Definition

Softened bones caused by low calcium intake, low exposure to sun or repeated pregnancy with lactation.

(Bow legged and bent over)

Term

Two types of Vitamin E

(8 total compounds)

Definition

Tocopherols

Tocotrienols

 

Both have alpha, beta, gamma and delta forms

Term
Functions of Vitamin E
Definition

FUNCTIONS:

Antioxidant

Reduces Oxidative Stress

Term
Food source of Vitamin E
Definition

FOOD SOURCES:

VERY little in animal and dairy

Plant oils

wheat germ

asparagus

almonds

peanuts

sunflower seeds

Term
Vitamin E loss is sensitive to...
Definition

Oxygen

Heat

Light

Metal

Term
Absorption of Vitamin E
Definition
20-70% of intake
Term
Aid in Vitamin E absorption
Definition
Bile and pancreatic enzymes
Term
Transport of Vitamin E
Definition
Chylomicrons transport to liver, then incorporated into lipoproteins.
Term
Storage of Vitamin E
Definition
Mostly in adipose, very little in muscle and liver.
Term

Vitamin E

RDA

Definition
15 mg/day of alpha-tecopherol
Term

Vitamin E 

Daily Value

Definition

20 mg

(30 IU)

Term
Micrograms per 1 IU Vitamin E
Definition

1 IU (synthetic) = .45 mg

1 IU (natural) = .67 mg

Term

Vitamin E

Average Intake

Definition
2/3 RDA
Term
Vitamin E Toxicity
Definition

Interference with Vitamin K

Hemorrhaging

Term

Vitamin E

Upper Limit

Definition

1000 mg (natural sources)

1100 IU (synthetic)

Term
Vitamin E Deficiency
Definition

Rare:

Hemolytic anemia

Nervous system damage

 

Term
At Risk for Vitamin E Deficiency
Definition

Premies

Fat malabsorption

Low-fat diets

Smokers

Term
Two forms of Vitamin K
Definition

Menaquinones

Phylloquinones

Term
Vitamin K that is made by colon bacteria and found in fish oils and meats.
Definition
Menaquinones
Term
Most biologically active form of Vitamin K found in green leafy vegetables, broccoli, peas and green beans.
Definition
Phylloquinones
Term
Function of Vitamin K
Definition

FUNCTIONS:

Blood clotting

Bone health

Reduce/Protect from Inflammation

Term
Absorption of Vitamin K
Definition

80% absorbed via chylomicrons in small intestines and lymphatic system.

 

10% of menaquinones made in colon are absorbed.

Term
Transport of Vitamin K
Definition
Lipoproteins and stored in liver.
Term

Vitamin K

RDA

Definition
NO RDA
Term

Vitamin K

AI

Definition

Women = 90 micrograms/day

Men = 120 micrograms/day

Term

Vitamin K 

Daily Value

Definition
80 micrograms
Term
Vitamin K toxicity
Definition
No UL
Term
Vitamin K deficiency
Definition

Rare:

May be associated with long-term antibiotic use or fat malabsorption. Potential for excessive bleeding.

 

Excessive Vitamins A and E interfere with Vitamin K production. 

Term
Vitamins newborns are injected with within 6 hours of birth...
Definition
Vitamin K
Term
Vitamin supplements must contain 1 or more of the following:
Definition

A mineral

A vitamin

An amino acid

A herb, botanical or plant extract

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