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NU 406:Maternal Health
Lecture 1
32
Health Care
Graduate
01/24/2007

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Term
Neural Tube Closure
Definition
3 weeks post conception

Neural tube becomes the spinal cord and the brain. You need folic acid for this!

Term
Heart Development
Definition
3 weeks for formation

4-5 weeks for four chambers

at 8 weeks we can hear the fetal heart

Term
Lips/Palate formation
Definition
Finished forming 6-8 weeks post conception

It's usually a teratogen that causes cleft palate

Term
Teratogen
Definition
Agent that acts directly on the developing fetus, causing abnormal embryonic or fetal development

Ex. viruses, bacteria, heavy metals, medications ect

Term
Placental Fuctions
Definition
Hormone production: hCG(marker for pregnancy), Human plaental lactogen, progesterone and estrogen

Metabolic functions: respiration (passing O2 to fetus, holds O2 reserve), nutrition, excretion (takes fetal watstes, CO2); storage

Term
Chorion
Definition
Fetal membrane--Outside, towards uterus. Contains chorionic villi on the surface (which are fingerlike projections extending into the endometrium to obtain O2/nutrients from the maternal blood stream and to dispose of embryonic wastes)

Contains umbilical blood vessels

becomes the covering of the fetal side of the placenta

Term
Amnion
Definition
Shiny

Becomes coering of the umbilical cord

Covers the chorion of the fetal surface of the placenta

Term
Embryonic Period
Definition
From day 15 to 8 weeks post conception

Most critical time in the development of organ systems and main external features

By the end of the 8 week post conception all organ systems and external structures are present

Term
Zygote
Definition
1st stage of pregnancy

From conception to day 15

Term
Chorionic Villi
Definition
Fingerlike projections into the endometrium whihc stick in the uterus to obtain O2/nutrients and to expel waste.

Derived from trophoblast tissue. (The tissue that becomes the placenta)

Term
Fetal Stage
Definition
From 9 weeks to birth

CNS and eyes are still developing and vulnerable to teratogens

Term
Viability
Definition
Ability of the fetus to survive otuside the womb

Usually around 22 weeks gestation (though they really only have a 25% survival rate, and 80% of those will have major health issues)

We usually do resusitation for fetuses at 24 weeks or over 500g.

Term
Ductus Venosis
Definition
Shunts most blood away from the liver, and to the heart (from the umbilical cord/mother). (A little blood does go to the liver for development purposes.)
Term
Foramen Ovale
Definition
Hole between the atria which allows blood to shunt from the right side of the heart to the left
Term
Ductus Arteriosis
Definition
Shunts blood from the pulmonary artery (around the lungs) into the aorta. (Some blood does go to the lungs to help with development)
Term
L/S ratio
Definition
Ratio of lecithin (the most critical surfactant required for postnatal lung expansion) to sphingomyelin (a surfactant which remains fairly constant)

The ratio of these to consider fetal lungs mature is 2:1, which occurs around 35 weeks.

You can give steriods to speed up the process

Term
ONTD
Definition
Open neural tube defect develops in the fourth week
Term
Fetal Antibodies
Definition
IgG- Passively acquired from mother. (It's the only one that goes from mom via the placenta)

IgM- fetus produces in the 1st trimester

IgA Not produced by the fetus; present in colostrum (the mother's first milk) These are aquired through breast feeding and help the gut.

Term
Goodell's Sign
Definition
Softening of the cervix (caused by the oomph of progesterone) Occurs around 6 weeks. Probable sign
Term
Chadwick's sign
Definition
Blue-purplish hue to cervix, due to increased vascularity. Probable sign
Term
Hagars Sign
Definition
Thinning of the lower uterine segment (isthmus); Probable sign
Term
Braxton Hicks Contractions
Definition
Less intense uterine contractions; "practice contractions"; Occur around 35 weeks.
Term
hCG
Definition
Human Chorionic gonadotrophin

Important in high risk pregnancies. You do serial hCG if there are multiple miscarriages or pregnancies

Term
*Nagele's Rule
Definition
Add 7 days to LMP

Subtract 3 mo

Add one year

Term
Quickening
Definition
Feeling the baby moves. Approximately 20 weeks in nullips
Term
Lightening
Definition
Also called fetal drop

Descent of fetus into the pelvis in the 3rd trimester

Nulliparous occurs 2 weeks before lapor

Mutiparous- occurs at the start of labor

Term
Cervical Os
Definition
Nullip-round

Multip- slit like

Term
CV changes
Definition
Increase blood volume by 45% (but mostly plasma, so decrease in Hct, HgB-less than 35Hct or 10g/dlHgb=anemia) increase CO, increase stroke volume, increase HR, increase heart size

BP: 1st trimester unchanged; 2nd trimester decreases; 3rd trimester returns to 1st trimester levels

Altered PMI

Term
**Supine Hypotension
Definition
Never allow a patient greater than 14weeks to lay flat on their back. The uterus compresses the vena cava, which reduces cardiac output and causes "supine hypotension"
Term
Renal Changes
Definition
You get more stasis b/c of malformation and stretching--counsil on UTI signs

frequency without being able to urinate, burning, blood in urine, pain) come in for UTI immediately because a bladder spasm can lead to premature labor

Term
Oxytocin
Definition
Stimulates uterine contractions and let down reflex
Term
TORCH
Definition
Toxoplamosis

Other: HepB, HIV, Syphilis (RPR); Herpes Zoster; Strep B

Rubella: SAB, congenital anomalies, hearing loss, psychomotor retardation

CMV-mental retardation; hearing deficits; microcephaly; hydrocephalus

Herpes-SAB; Preterm labor; HSV development; death

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