Term
|
Definition
- interfere with dna replication
- cell cycle nonspecific
- tx for leukemia, multiple myeloma
|
|
|
Term
|
Definition
- cyclophosphamide/cytoxan
- hemorrhagic cystits - blood in bladder
|
|
|
Term
|
Definition
- inhibit nucleic acid synthesis
- tx for ALL, many ca
- s/e
|
|
|
Term
| alkylating agents s/e are ? |
|
Definition
- bone marrow suppression
- severe N/V
- stomatitis
- alopecia
- birth defects
|
|
|
Term
| Antimetabolites drugs are ? |
|
Definition
- cytarabine/ARA-C
- hepatoxicity, protect conjunctiva
- methotrexate/foley
- hepatoxicity, pneumonitis, renal failure
|
|
|
Term
| antimetabolites S/E are ? |
|
Definition
- bone marrow suppression
- N/V
- diarrhea
- alopecia
- stomatitis
- cns damage
|
|
|
Term
| antitumor antibiotics are ? |
|
Definition
- prevent dna and rna synthesis
- tx for hodgkins, NHL, leukemia, many ca
|
|
|
Term
| antitumor antibiotics drugs are ? |
|
Definition
- doxorubicin/adriamycin
- myocardial toxicity 2nd prevention
- bleomycin/blenoxane
- pulmonary toxicity
- renal/hepatitc toxicity
|
|
|
Term
| antitumor antibiotics S/E are ? |
|
Definition
- bone marrow suppression
- N/V
- alopecia
- pulmonary toxicity
- renal toxicity
- hepatic toxicity
- heart damage
- tissue toxicity
|
|
|
Term
| Mitotic spindle poisons are ? |
|
Definition
- are plant extracts that arrest cell division
- tx for hodgkins, lymphoma, ca
|
|
|
Term
| mitotic spindle poison drugs are ? |
|
Definition
- vincristine/oncovin
- vinblastine/velban
- constipation
- loss of reflexes
|
|
|
Term
| mitotic spindle poison S/E are? |
|
Definition
- bone marrow suppression
- N/V
- stomatitis
- autonomic neuropathy
- paralytic ileus
- neurotoxic
|
|
|
Term
|
Definition
- tx for ALL, leukemias
- asparaginase/elspar - inhibits protein synthesis
- mood disorders
- hepatoxicity
- renal tox
- altered glucose metabolism
|
|
|
Term
|
Definition
- hormonal dependent tumors
- androgens
- estrogens/anti estrogen
- progestin
- adrenal cortical compounds/ anti adrenal
|
|
|
Term
| hormonal agents drugs are ? |
|
Definition
- tomaxifen/nolvodex - anti estrogen
- testolactone/teslec - androgen
- palliative in advanced breast cancer
|
|
|
Term
|
Definition
- hypercalcemia
- jaundice
- increased appetite
- fluid retention
- htn
- hypokalemia
- diabetes
- immunosuppression
- mood swings
- psychosis
|
|
|
