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Nonmalignant Granulocyte and Monocyte Disorders (Neutrophil)
Hematology
10
Biology
Undergraduate 4
12/04/2011

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Term
Dohle Bodies
Definition
Light, bright-blue, oval inclusions
Aggregates of ER
Seen in severe infections, cancer, toxic states, and burns
Term
Toxic Granules
Definition
Deep-bluish-black primary granules
Seen in severe infections, cancer, toxic states, and burns
Term
Cytoplasmic Vacuoles
Definition
Clear areas of cytoplasm
Seen in septicemias
Term
Intercellular Organisms
Definition
Digested bacteria or parasites that have not been broken down
Term
Chronic Granulomatis Disease
Definition
Affects the Respiratory-Burst-Oxidase System
People with this die at 5-7 years old
Term
Myeloperoxidase Deficiency
Definition
Lack of myeloperoxidase
Benign
Term
Leukocyte Adhesion Deficiency
Definition
No leukocyte adhesion proteins
Deadly
Term
Alder-Reilly
Definition
Neutrophils have large, purple granules in the cytoplasm
Missing enzymes result in increased mucopolysaccharides
Cells function normally
Seen in Hurler's Syndrome and Hunter's Syndrome
Term
Chediak-Higashi
Definition
Results in death in childhood or infancy
Cells cannot kill off bacteria
Symptoms include skin pigmentation, silvery hair, and photophobia
Neutrophils have giant, gray-green, peroxidase-positive granules in the cytoplasm
Term
May-Hegglin
Definition
Rare
Autosomal Dominant
Neutrophils have inclusions, similar to dohle bodies, made up of RNA from the ER
Neutrophils function normally, but the platelets do not
Thrombocytopenia
Giant platelets that result in bleeding
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