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Noel Test 2
Mitosis, Mendelian Genetics
47
Biology
Undergraduate 1
02/25/2008

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Term
Chromosomes
Definition
LInear structures that contain DNA
Term
Chromatin
Definition
Threads of chromosomes containing DNA wrapped around protein.
Term
Histones
Definition
Spools that DNA is round around
Term
Homologous chromosomes
Definition
A pair of the the same numbered chromosome.  IE chromosome 16. 
Term
Sister Chromatids
Definition
AFter the replication of DNA in the S phase: 2 replicas of a single chromosome held togetehr by a centromere.  Seperated in anaphase. 
Term
Autosomes
Definition
The 22 chromosomes in the male and female human that perfectly matched
Term
Sex chromosomes
Definition

XX in females, XY in males.  Determine sex.  23rd chromosome. 

Term
Haploid
Definition
One set of chromosomes from the 2.  23 chromosomes.  ONe haploid set from the mother and one from the father. 
Term
Diploid
Definition
The complete set of chromosomes an individual has from both parents. 46 chromes in total. 
Term
Tetraploid
Definition
Four sets of chromosomes. 
Term
Karyotype
Definition
The chromosome array an individual possesses.
Term
Condensation
Definition
Where the chromosomes are tightly coiled in the G2 phase of the cell cycle. 
Term
Mitotic Spindle 
Definition
A spindle apparatus composed of microtubules that is vital in arranging the chromosomes during mitosis. 
Term
Kinetochores
Definition
Protein disks attached to the centromere that attach the sister chromatids to the mitotic spindle. 
Term
Centromeres
Definition

Connectors between the two sister chromatids during mitosis (prophase and metaphase) that are broken down during anaphase. 

Term

Interphase

Definition
G1, S, G2.  The life cycle of the cell. 
Term

G1

Definition
The primary growth phase of the cell.  Doing work, having fun, ripping shit up.  Typical g1 phase. 
Term

S Phase

Definition
Where the DNA is replicated in the cell. 
Term
G2
Definition
Second growing phase of the cell, prepartion for mitosos where organelles are replicated. 
Term

Prophase

Definition

Chromosomes condense, mitotic spindle begins to form, kinetochores begin to mature, attach to spindle. 

Term
Metaphase
Definition
Sister chromatids align at the equator, chromosomes attach to mitotic spindle.  Prep for anaphase. 
Term
Anaphase
Definition
Where the sister chromatids split, kinetochores shorten, sister chromatids go to opposite poles, pulled by mitotic spindle. 
Term

Telophase

Definition
Kinetochores disappear, chromosomes condense, nuclear membrane begins to form, beginning the split into 2 different cells. 
Term
Cytokinesis
Definition

Where the cell splits into 2 with = amounts of genetic material.  "Cleaving" 

Term
Difference between animals and plants. 
Definition

Animals, cleavage furrow splits the cells.

Plants:  Cell plate forms and divides the daughter cells. 

Term
G1 Checkpoint
Definition
Determines whether the cell goes into the S phase.  Influenced by external signals, growth factors, nutritional state of the cell, size of the cell. Started by a large accumulation of S-phase cyclin.   
Term
G2 Checkpoint
Definition
Determines whether cell goes to metaphase.  Analyzes DNA integrity.  Influenced by MPF
Term

MPF

Definition
Metaphase promoting factor.  Comosed of a cyclin dependent kinase (CDK) that's controlled by inhibitory phosphorylation of cdc2.  "Removes inhibitor phosphates which then starts metaphase."  Activity:  analyzes if DNA is damaged, if it is, adds inhibitory kinases to the enzyme. 
Term
APC
Definition
Anaphase promoting complex.  Activity:  seperates the sister chromatids by removing the inhibitors of a protease that destroys the cohesin complex allowing the sis tits to seperate.  this is called proteolysis. 
Term
Growth Factors
Definition
Proteins that stimulate cell division by binding to a membrane receptor and starting a reaction cascade. 
Term
PDGF
Definition
Platelet-derived growth factor.  Example of a growth factor, overrides cellular controls that inhibits cell division.  Triggers cells to divide, healing wounds. 
Term
Cancer
Definition
The unrestrained growth of cells.  General defect:  a failure of cellular control.  A defect in p53
Term
p53
Definition
Tumor suppressor gene that becomes a protein that momitors DNA, making sure it's good, if not the cell goes to apoptosis. 
Term
Proto-Oncogenes
Definition
Positive regulators of the cell cycle that turn cell "on" for replication. 
Term
Gametes
Definition

Sex cells.  Sperm in males, egg in females. 

Term
Meiosis
Definition
Process of cell division in which the number of chromosomes is halved during gamete formation.  Begins with fertilization. 
Term
Fertilization
Definition
Egg meeting sperm, 46 chromosomes, to make a zygote.  "Little baby." 
Term
Essence of meisosis vs. mitosis
Definition
One replication, 2 divisions = 4 seperate cells with equal amount of data.  Crossing over of DNA in prophase during tetrad formation. 
Term
Prophase I
Definition
Chromosomes condense, synapsis occurs:  crossing over of DNA forming chiasmata. 
Term
Metaphase I
Definition
Pairs of homologous chromes align at the equator. 
Term
Anaphase I
Definition
Homologs seperate (synapsis ceases) but the sister chromatids do not seperate, remain joined. 
Term
Telaphase 1 and cytokinesis
Definition
Spindle dissapears, nuclei reform, cell division occurs. 
Term
Meiosis 2
Definition

Exactly the same as mitosis but this time there are 2 cells in the beginning with 2 chromosomes each which seperate into 4 cells altogether.  No S phase at start. 

Term
Character and trait
Definition

Character:  inherited feature.  Example: flower color.

Trait:  Variants of an inherited character: ie flower color of red or purple or white. 

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