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Details

Nicotine Dependence and Smoking Cessation
pages 43-48
16
Biology
Professional
02/01/2012

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Cards

Term
What has been the most effective deterrent against smoking in the US?
Definition
Public health efforts to decrease the "acceptability of smoking"

Still, the worldwide smoking rate is increasing.
Term
True of False: Nicotine is known to be carcinogenic.
Definition
False,

of the 6000 compounds in cigarettes, nicotine is not carcinogenic (while dozens of others are).
Term
What is the most immediate health benefit of stopping smoking in terms of disease development?
Definition
CHD is not dose-dependent and is more acute, with sharp reduction within a few years of quitting.
Term
What are some of the consequences of chronic nAcHR desensitization on the receptors themselves.
Definition
Increased receptor number

1 month or so after cessation, this number returns to normal.
Term
What are some of the consequences of chronic nAcHR desensitization on the receptors themselves.
Definition
Increased receptor number

1 month or so after cessation, this number returns to normal.
Term
Which nAcHR are most important in smoking?
Definition
Remember, nicotine reaches the brain 20 s after the first cigarette of the day.

1) alpha4beta2 in VTA (projecting to NA) leads to dopamine release, along with NE and E (acute mood and behavioral effects)

2) alpha7 (withdrawal)
Term
What populations are affected by smoking the most?
Definition
Poor, mentally diseased (70% of Schizophrenia and 30-40% in depression) and drug abusers (alcoholics and cocaine users at 80%)

This means, the population that needs help is the hardest to help!
Term
What are the 5 "A"s of treatment for smoking?
Definition
1) Ask about it at every visit

2) Advise smokers to quit

3) Assess dependence, comorbidity

4) Assist with quitting

5) Arrange followup
Term
What are the 4 "Rs" to use if patients are not interested in quitting?
Definition
1) Relevance (tailor to smoker's interests)

2) Risks

3) Rewards

4) Repetition
Term
What are some approved treatments for smoking cessation?
Definition
1) Nicotine replacement

- prescription examples include Bupropion (Zyban), Varencicline (Chantix)

2) NRT patch "priming" before cessation date

3) Nortripyline-(antidepressent and Clonidine (anti-hypertensive)
Term
What is the most important aspect of a counseling session designed to help someone quit?
Definition
SET A QUIT DATE
Term
True or False.

Acupuncture and Hypnosis have proven effects in improving quitting rates as a secondary therapy.
Definition
False, no proof!
Term
What are some common reasons for relapse?
Definition
1) Lack of social support

2) Ambivalence

3) Weight gain

4) Stress
Term
How can you assess abstinence at a follow-up visit?
Definition
MUST VERIFY IT

Verify Biochemically

1) Expired CO- cheap but only 12-24 hours

2) Salivary and urinary cotinine-3/4 days but $30 a pop and dip-stick is binary

If successful, praise, but if unsuccessful, re-assess.
Term
What steps have been shown to effectively prevent smoking and which need more work?
Definition
1) Effective strategies include, tobacco taxes, smoke-free workplaces and counter-advertising

2) School-based education, warning labels need to be bigger and graphic, laws prohibiting sales to minors should be enforced.
Term
What important contribution was made by the Family Smoking Prevention and Tobacco Control Act (2009)?
Definition
Allows FDA to regulate tobacco products (nicotine content, health warnings, industry marketing, disclosure and elimination of additives).
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