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Neuroscience
Chpt 4.- UMT Intro to Neuroscience.
15
Medical
Undergraduate 3
09/26/2009

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Term
Rising Phase
Definition
Rapid depolarization of the membrane. Cell reaches 40 mV.
Term
Overshoot
Definition
Part of the action potential where the inside of the neuron is positively charged with respect to the outside.
Term
Falling Phase
Definition
Rapid repolarization until the membrane is more negative than resting potential.
Term
Undershoot / After-hyperpolarizaion
Definition
Gradual restoration of resting potential.
Term
Threshold
Definition
Critical level of depolarization required to generate an action potential.
Term
Absolute refractory period.
Definition
Period after an action potential where it is impossible to initiate another. Lasts ~1 msec.
Term
Relative Refractory Period
Definition
Period in which the relative current required to initiate an action potential is elevated above normal.
Term
Voltage Clamp
Definition
Allows researchers to "clamp" the membrane potential at a level of their choosing.
Term
Voltage Gated Sodium Channel
Definition
A membrane pore that is highly selective to Na+ ions.
Term
Patch Clamp
Definition
Allows the study of ion currents by sealing an electrode to a small patch of membrane.
Term
Channelopathy
Definition
Human genetic disease caused by alterations is structure/function of ion channels.
Term
Tetrodotoxin (TTX)
Definition
Toxin found in puffer fist. Clogs Na+ channels.
Term
Voltage Gated Potassium Channels
Definition
A membrane pore that is highly selective to K+ ions.
Term
Saltatory Conduction
Definition
Type of ion movement produced between nodes of ranvier due to mylenation.
Term
Spike Initiation Zone
Definition
Axon Hillock.
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