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Neuropharm.-Autonomic NS
Dr. Stephen Durst's Lecture
34
Health Care
Undergraduate 2
02/11/2007

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Cards

Term
What are the 3 types of cholinergic receptors?
Definition
1. Nicotinic (n)
2. Nicotinic (m)
3. Muscarinic
Term
What is the neurotransmitter that stimulates cholinergic receptors?
Definition
Acetylcholine
Term
What is the neurotransmitter that stimulates adrenergic receptors?
Definition
Epinephrine (Adrenaline)
Term
Alpha 1 is what kind of receptor and associated with which organs?
Definition
Adrenergic;
Arterioles, bladder, eyes
Term
Beta 1 is what kind of receptor and associated with which organ.
Definition
Adrenergic;
heart
Term
Beta 2 is what kind of receptor and associated with which organ?
Definition
adrenergic;
lungs
Term
cholinergic receptors are mostly assoc. with parasympathetic or sympathetic system?
Definition
parasympathetic
Term
adrenergic receptors are mostly assoc. with parasympathetic or sympathetic system?
Definition
Sympathetic
Term
Cholinergic agonist drug
Definition
Bethanechol
Term
Cholinergic antagonist drug
Definition
Atropine
Term
2 drugs used to prevent the breakdown of Ach?
Definition
Neostigmine, Physostigmine
Term
What is a irreversible cholinesterase inhibitor that is used in chemical warfare?
Definition
Organophosphate
Term
What is the irreversible cholinesterase inhibitor that is used to treate glaucoma?
Definition
Ecothiophate
Term
What is the drug that can restore ChE activity when exposed to irreversible ChE agents?
Definition
Pralidoxime
Term
A prototype non-depolarizing agent that competes with Ach at the NicotinicM receptors of skeletal muscle?
Definition
Tubocurarine
Term
The only depolarizing neuromuscular blocker in use?
Definition
Succinylcholine
Term
Name 1 ganglionic blocking agent.
Definition
Mecamylamine (Inversine)
Term
What agonists produce the same effects as seen with norepi and epi?
Definition
Adrenergic agonists
Term
Dobutamine is specific to what type of receptor?
Definition
Beta 1
Term
Stimulation of what type of receptors results in a decrease of NE release?
Definition
Alpha 2
Term
Which receptor has principle actions of vasoconstriction and midriasis(pupil dilation)?
Definition
Alpha 1
Term
Low doses of dopamine will increase what?
Definition
Renal blood flow
Term
Medium doses of dopamine will lead to stimulation of what type of receptors?
Definition
Beta 1
Term
High doses of dopamine stimulate alpha-1 receptors leading to...?
Definition
vasoconstriction
Term
Norepinephrine is similar to epinephrine except for the lack of what type of receptor stimulation?
Definition
Beta 2
Term
A potent vasoconstrictor.
Definition
Norepinephrine
Term
Isoproterenol acts on which receptors?
Definition
Beta 1 and 2
Term
Which receptor(s) does Dobutamine act on?
Definition
Beta 1
Term
Which drug stimulates alpha-1 receptors and is used as a nasal decongestant, in prep to dilate pupils, and increase blood pressure in severe hypotension?
Definition
Phenylephrine
Term
Terbutaline is used to induce bronchodilation and is used to stimulate what type of receptors?
Definition
Beta 2
Term
What is the effect on blood pressure if you block alpha-1 receptors?
Definition
lowered blood pressure
Term
What is the only noncompetitive alpha-blcoker that results in a much longer duration of action?
Definition
Phenoxybenzamine
Term
Name 2 drugs that are beta-1 selective beta blockers?
Definition
Esmolol and Metoprolol
Term
Name 1 drug that is a nonselective beta blocker?
Definition
Propranolol
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