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Neurons, Synapses, and Signaling
Chapter 48
44
Biology
Undergraduate 2
05/09/2015

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Term
neurons
Definition
the nerve cell that transfers information within the body
Term
brain
Definition
organ of the central nervous system where information is processed and integrated
Term
ganglia
Definition
singular ganglion; a cluster of nerve cell bodies in a centralized nervous system
Term
axon
Definition
an extension that transmits signals to other cells
Term
synapse
Definition
the junction where a neuron communicates with another cell across a narrow gap via a neurotransmitter or an electrical couplin
Term
neurotransmitters
Definition
chemical messengers that pass information fom the transmitting neuron to the receiving cell
Term
glia (glial cell)
Definition
cells of the nervous system that support, regulate, and augment the functions of neurons
Term
sensory neurons
Definition
transmit information about external stimuli such as light, touch, or smell, or internal conditions such as blood pressure or muscle tension
Term
interneurons
Definition
form the local circuits connecting neurons in the brain
Term
motor neurons
Definition
transmit signals to the muscle cells, causing them to contract
Term
peripheral nervous system (PNS)
Definition
the sensory and motor neurons that connect to the central nervous system; carry information into and out of the central nervous system
Term
membrane potential
Definition
the difference in electrical charge (voltage) across a cell's plasma membrane due to the differential distribution of ions. It affects the activity of excitable cells and the transmembrane movement of all charged substances
Term
resting potential
Definition
the membrane potential characteristic of a nonconducting excitable cell, with the inside of the cell more negative than the outside
Term
sodium-potassiu pump
Definition
a transport protein in the plasma membrane of animal cells that actively trasports sodium out of the cell and potassium into the cell
Term
ion channel
Definition
a transmembrane protein channel that allows a specific ion to diffuse across the membrane down its concentration or electrochemical gradient
Term
equilibrium potential
Definition
the magnitude of a cell's membrane voltage at equilibrium calculated using the Nernst equation
Term
gated ion channels
Definition
ion channels that open or close in response to stimuli, altering the membrane's permeability to particular ions, which in turn alters the membranes potential
Term
hyperpolarization
Definition
a change in a cell's membrane potential such that inside the membrane becomes more negative relative to the outside. It reduces the chance that a neuron will transmit a nerve impulse
Term
depolarization
Definition
a change in a cell's membrane poteential such that inside the membrane is made less negative relative to the outside
Term
voltage-gated ion channels
Definition
ion channels in neurons where the opening and closing depends on when a membrane potential passes a particular level
Term
threshold
Definition
the potential that an excited cell membrane must reach for an action potential to be initiated
Term
refractory period
Definition
the short time immediately after an action potential in which the neurons cannot respond to another stimulus, owing to the inactivation of voltage-gated sodium channel
Term
myelin sheath
Definition
wrapped around the axon of a neuron, and insulating coat of cell membranes from Schwann cells or oligodendrocytes
Term
oligodendrocyte
Definition
a type of glia cell that forms insulating myelin sheaths around the axons of neurons in the central nervous system
Term
schwann cells
Definition
atype of glial cell that forms insulating myelin sheaths around the axon of neurons in the peripheral nervous system
Term
nodes of ranvier
Definition
gap in the myelin sheath of certain axons where an action potential may be generated.
Term
saltatory conduction
Definition
rapid transmission of a nerve impulse along an axon, resulting from the action potential jumping from one node of ranvier to another, skipping the myelin-sheathed regions of the membrane
Term
synapsis vesicle
Definition
multiple membrane enclosed compartments
Term
synapsis cleft
Definition
the gap that seperates the presynaptic neuron from the postsynaptic cell
Term
excitatory postsynaptic potential (EPSP)
Definition
an electrical charge (depolarization) in the membrane of a postsynaptic cell caused by binding of an excitory neurotransmitter from a presypnatic receptor makes it more likely for the postsynatic cell to generate an action potential
Term
inhibitory postsynaptic potential (IPSP)
Definition
an electrical charrge (usually hyperpolarization)in the membrane of a postsynaptic neuron caused by the binding of an inhibitory neurontransmitter from a presynaptic cell to a postsypnatic receptor; makes it more difficult for a postsypnatic neuron to generate an action potential
Term
temporal summation
Definition
a phenomenon of neural integration in which the membrane potential of the postsynaptic cell in the chemical synapse is determines by the combined effect EPSP's or IPSP produced in rapid succession.
Term
spartial summation
Definition
a phenomenon of neural integration in which the membrane potential of the postsynaptic cell is determined by the combined effect of EPSP and IPSPs produced nearly stimultaneously by different synapses
Term
aceptylcholine
Definition
one of the most common neurotransmitters; functions by binding to receptors and altering the permeability of the postsynaptic membrane to specific ions; either polorizing or hyperpolarizing the membrane
Term
glutamate
Definition
one of the several animo acids that can act as a neurotrasmitter
Term
gamma-aminobutyric acid(GABA)
Definition
the neurotransmitter at most inhibitory synapses in the brain
Term
biogenic amines
Definition
a neurotransmitter derived from an amino acid
Term
nonrepinephrine
Definition
a catecholamine that os chemically and functionally similar to epinephrine and acts as a hormone or neurotransmitter; also called noradrenaline
Term
epinephrine
Definition
a hormone and a neurotransmitter
Term
dopamine
Definition
a neurotransmitter that is a catecholamine, like epinephrinw and nonepinephrine ;are released at many sites of the brain and affect sleep, mood, attention, and learning
Term
serotonin
Definition
a neurotransmitter, synthesized from the amino acid tryptophan, that functions in the central nervous system, are released at many sites of the brain and affect sleep, mood, attention, and learning
Term
neuropeptides
Definition
a relative short chain of amino acids that serve as neurotransmitters
Term
endorphins
Definition
any of several hormones produced in the brain and anterior petuitary that inhibit pain perception
Term
substance p
Definition
neuropeptide that is a key excitatory neurotransmitter thaat mediates our perception of pain
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