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Neurology Exam 3 — Clinical Review
Flash cards for exam 3 covering clinical from exams 1 & 2
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Biology
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05/12/2013

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Term
Artery of cerebral hemorrage aka
Definition
Lateral-most branch of lenticulo-striate branches of MCA
Term
Down and out syndrome aka
Definition
CN III nucleus or nerve lesion
Term
Sacral sparing
Definition
Internal spinal cord lesions affect sacral spinothalamic fibers last
Term
3 L's of localization of lesions
Definition
1) Level, 2) location, 3) laterality
Term
8 basic causes of CNS lesions
Definition
1) Trauma, 2) ischemia, 3) neoplasm, 4) neurodegeneration, 5) toxins, 6) infection, 7) nutrition, 8) genetic
Term
Achilles reflex test what spinal cord segments
Definition
S1-2
Term
Activation of baroreceptors leads to ___ [increase or decrease] of SNS
Definition
Decrease
Term
Activation of D1 receptors would be __ [facilitative or inhibitive] of movement
Definition
Facilitive
Term
Activation of D1 receptors: facilitates or inhibits movement
Definition
Facilitates
Term
Activation of D2 receptors would be __ [facilitative or inhibitive] of movement
Definition
Inhibitive
Term
Activation of D2 receptors: facilitates or inhibits movement
Definition
Inhibits
Term
Activation of dynorphin MSN: facilitates or inhibits movement
Definition
Facilitates
Term
Activation of enkephalin: facilitates or inhibits movement
Definition
Inhibits
Term
Activation of GPe: facilitates or inhibits movement
Definition
Facilitates
Term
Activation of GPi/SNR: facilitates or inhibits movement
Definition
Inhibits
Term
Activation of PMCTX: facilitates or inhibits movement
Definition
Facilitates
Term
Activation of STN: facilitates or inhibits movement
Definition
Inhibits
Term
Activation of VA: facilitates or inhibits movement
Definition
Facilitates
Term
Akathisia
Definition
Non-stop fidgeting, etc.
Term
Alien hand syndrome from damage to
Definition
Premotor cortex
Term
Alternating signs: medial or lateral medullary syndrome
Definition
Lateral
Term
Alternating/crossed signs
Definition
Right face & left body; vice versa; etc.
Term
Amygdala primary responsibility
Definition
Associative learning
Term
Angiotensin II affects what region of the brain
Definition
Subfornical region [for ADH release]
Term
Anterior cord syndrome symptoms (3)
Definition
1) Complete bilateral motor paralysis, 2) complete bilateral loss of pain & temperature, 3) spares 2-point discrimination, vibration, kinesthesia
Term
Anterior group connects to what (2)
Definition
1) Parahippocampal region to fornix & mammillary bodies via mammillothalamic tract; 2) cingulate gyrus
Term
Anterior group: sensory, motor, association, limbic, or non-specific
Definition
Limbic
Term
Anterior hypothalamus lesions lead to __ [hypo- or hyperthermia] due to loss of __ [MPOA or DMH]
Definition
Hyperthermia due to loss of MPOA
Term
Anterior lobe blood supply
Definition
SCA & AICA (ventral)
Term
Anterior lobe function
Definition
Motor control
Term
Anterior spinal artery supplies roughly ___ [fraction] of the cross-sectional area
Definition
3-Feb
Term
Anterior spinal artery supplies what structures (6)
Definition
1) Ventral horn, 2) intermediate zone, 3) most lateral corticospinal tract, 4) anterolateral system, 5) vestibulospinal tract, 6) bulbospinal tract
Term
Anti-pyretics work by __ [inhibiting or activating] the __ [PMOA or DMH]
Definition
Inhibt PMOA [by reducing prostaglandin production]
Term
Aphasia: affects which thalamic nucleus
Definition
Pulvinar
Term
Apneustic center ___ [inhibits or drives] inspiration
Definition
Drives inspiration
Term
Arcuate nucleus functions
Definition
Appetite & consumption
Term
Arterial supply of thalamus (4)
Definition
1) Posterior chorodal, 2) paramedian, 3) tuberothalamic, 4) inferolateral
Term
Ascending loss of pain/termperature, and motor paresis indicates ___ [superficial or deep] lesion
Definition
Superficial
Term
Ascending reticular activating system (ARAS) does what
Definition
Forced attention & consciousness
Term
Association nuclei of the thalamus (2)
Definition
MD, pulvinar
Term
Asymmetric tongue: medial or lateral medullary syndrome
Definition
Medial
Term
Atheromatous plaques
Definition
Concentrate at points where turbulence is greatest
Term
Auditory nuclei pathway starting with the cochlear neurons (6)
Definition
Inner hair cell → DCN/VCN → superior olivary complex → inferior colliclus → medial geniculate body/nucleus → primary auditory cortex
Term
Autism?
Definition
Maybe a connection with the cerebellum
Term
Back pain is considered what kind of pain
Definition
Visceral pain
Term
Bacterial meningitis changes CSF how
Definition
Cloudy appearance
Term
Ballism cause
Definition
Lesion of sub-thalamic nucleus
Term
Baroreceptor reflex pathway (4)
Definition
CN IX/X → NTS → ventrolateral medulla → CN X/SNS outflow
Term
Basal ganglia primary responsibility
Definition
Regulation & coordination of movement
Term
Basal pontine syndromes symptoms (general)
Definition
Ipsilateral CN signs with contralateral UMN body signs
Term
Benedikt's syndrome
Definition
CN III palsy + contralateral coarse tremors (cerebellothalamic fibers, red nucleus, substantia nigra) +
Term
Benedikt's syndrome etiology
Definition
Lesion of the midbrain tegmentum
Term
Biceps reflex test what spinal cord segments
Definition
C5-6
Term
Blood flow of normally functioning neurons
Definition
40-55 mL/min/100 gm
Term
Blood flow ratio to gray matter over white matter
Definition
About 2.5 (70-80 vs 30 mL/min/100 g)
Term
Blood flow to induce irreversible brain damage
Definition
<20 mL/min/100 gm for several minutes
Term
Blood supply to nucleus gracilis & cuneatus
Definition
Posterior spinal a.
Term
Blood supply to pons (3; medial to lateral)
Definition
Paramedian → short circumferential → long circumferential
Term
Blood supply to the pyramids
Definition
Anterior spinal a.
Term
Blood supply to the spinal trigeminal nucleus
Definition
Vertebral a.
Term
Brachial diplegia
Definition
Inability to abduct arms and flex elbows from watershed stroke
Term
Brown-Séquard syndrome
Definition
Hemisection of the spinal cord [largely academic]
Term
Can NTS lesions lead to necrosis of cardiac myocytes: yes or no
Definition
Yes
Term
Categories of spina bifida (4; mildest to severest)
Definition
1) Occulta, 2) meningocoele, 3) meningomyelocoele, 4) craniorachischisis
Term
Cauda equina syndrome
Definition
Spinal stenosis of dorsal & ventral roots
Term
Cauda equina syndrome symptoms (5)
Definition
1) Weakness of the leg & foot (LMN signs), 2) saddle anesthesia (S1-5 dermatomes), 3) loss of patellar & achelles reflexes (ventral root damage), 4) urinary retention, 5) loss of tone in external anal sphincter
Term
Caudal basis pontis lesions would cause what symptoms (2)
Definition
1) Ipsilateral facial LMN hemiplegia, 2) contralateral UMN hemiplegia
Term
Caudal tegmental lesions would affect what structures (2)
Definition
1) CN VII palsy, 2) conjugate gaze palsy (via CN VI nucleus--CN VII fibers wrap around abducens nucleus)
Term
Causes of kernicterus (3)
Definition
1) Excess bilirubin, 2) inability to conjugate bilirubin, 3) immaturity/disruption of the BBB
Term
Causes of spinal stenosis (5)
Definition
1) Disc herniation, 2) spondylosis, 3) tumors, 4) dislocation, 5) fluorosis
Term
Cellular effects of spinal cord injury (5)
Definition
1) White & grey matter transection, 2) edema, 3) swelling, 4) necrosis/apoptosis, 5) scarring
Term
Central cord syndromes characterized by (3)
Definition
1) Bilateral loss of pain & temperature, 2) sacral sparing, 3) greater motor impairment in upper vs. lower extremities (UMN=exaggerated reflexes, LMN=atrophy)
Term
Cerebellar deficits (2)
Definition
Degradation of 1) fine movements, 2) posture
Term
Cerebellar syndromes exhibit __ [ipsi- or contralateral] signs
Definition
Ipsilateral
Term
Cerebellum hemisphere syndrome features (8)
Definition
1) Limb ataxis, 2) dysmetria, 3) dyssynergia, 4) adiadochokinesis, 5) volitional tremor, 6) hypotonia, 7) dysarthria, 8) nystagmus
Term
Cerebellum primary responsibility
Definition
Coordinating movement
Term
Cerebellum's function
Definition
Continuous feedback about body & limb position
Term
Cerebral aneurysms hemhorrages in what space
Definition
Subarachnoid space
Term
Chiari malformation
Definition
Cerebellum vermis herniates through foramen magnum; asymptomatic
Term
Circumventricular organs (7)
Definition
1) Postrema, 2) subcommissural organ, 3) subfornical organ, 4) vascular organ of the lamina terminalis, 5) median eminence, 6) neurohypophysis, 7) pineal gland
Term
Clinical features of Huntington's (3)
Definition
1) Onset post-child-bearing years, 2) chorea, 3) dementia
Term
Clinical features of Parkinson's (5)
Definition
1) Resting tremor, 2) bradykinesia, 3) rigidity, 4) loss of postural reflexes, 5) non-motor symptoms
Term
Clinical signs of vestibular damage: V=, A=, N=, N=
Definition
Vertigo, ataxia, nystagmus, nausea/vomitting
Term
Cocaine interfers at what stage of development
Definition
Neuronal differentiation
Term
Cochlear startle reflex
Definition
Move limbs in response to sound
Term
Complications of subarachnoid hemorrhage (2)
Definition
1) Rebleeding, 2) vasospasm → ischemic stroke
Term
Conductive or sensorineural hearing loss: aminoglycoside antibiotics
Definition
Sensorineural
Term
Conductive or sensorineural hearing loss: congenital cochlear deformation
Definition
Sensorineural
Term
Conductive or sensorineural hearing loss: loud sound
Definition
Sensorineural
Term
Conductive or sensorineural hearing loss: otitis media
Definition
Conductive
Term
Conductive or sensorineural hearing loss: otosclerosis
Definition
Conductive
Term
Contains ipsi- and contralateral fibers: medial or lateral vestibulospinal tract
Definition
Medial vestibulospinal tract
Term
Contains ipsilateral fibers: medial or lateral vestibulospinal tract
Definition
Lateral vestibulospinal tract
Term
Contraction band necrosis
Definition
Myocardial damage during contraction from calcium entry and free radical release
Term
Contralateral hemianopsia/quadrantopsia caused by lesion in what nucleus
Definition
LGN
Term
Contralateral UMN signs: medial or lateral medullary syndrome
Definition
Medial
Term
Conus medullaris syndrome symptoms (4)
Definition
1) Bladder & bowel problems, 2) sexual dysfunction, 3) UMN signs, 4) loss of perianal winking
Term
Corneal blink reflex pathway
Definition
Aδ nociception → V1 → spinal trigeminal → facial nucleus → orbicularis oculi m.
Term
Cortical heterotopia
Definition
Normal neurons in abnormal location from stalled migration
Term
Corticobulbar tract to muscles of
Definition
Cranial nerve motor nuclei
Term
Corticospinal fibers that do decussate in the medulla form what in the spinal cord
Definition
Lateral corticospinal
Term
Corticospinal fibers that do NOT decussate in the medulla form what in the spinal cord
Definition
Anterior corticospinal
Term
Corticospinal system: interneuron connection between upper and lower motor neurons typically are: excitatory or inhibitory
Definition
Inhibitory
Term
Corticospinal system: lower motor neuron location
Definition
Ventral horn
Term
Corticospinal system: upper motor neurons found where
Definition
Cerebral cortex [not just motor cortex]
Term
Corticospinal tract to muscles of
Definition
Hand muscles primarily, some to trunk/shoulder/hips
Term
Countrecoup
Definition
Brain hitting opposite side of skull from blunt trauma thus causing injury on the opposite side
Term
Cuneocerebellar tract function
Definition
Fine coordination of posture & movement of individual upper limb muscles
Term
Cuneocerebellar tract: ipsilateral or contralateral
Definition
Ipsilateral
Term
Damage to fornix in __ syndrome
Definition
Korsakoff's
Term
Damage to medial forebrain bundle leads to
Definition
Appetite effects
Term
Dandy Walker malformation of the
Definition
Vermis with cyst in 4th ventricle
Term
DCML decussates where
Definition
Medulla
Term
DCML is ordered (medial to lateral): sacral-to-cervical or cervical-to-sacral
Definition
Sacral (medial) to cervical (lateral)
Term
DCML second-order axons travel through what tract
Definition
Medial lemniscus
Term
DCML second-order neuron starts where
Definition
Nucleus in the medulla
Term
DCML through which spinal cord fasciculi (2; lateral to medial)
Definition
1) Fasciculus cuneatus, 2) fasciculus gracilis
Term
DCML to which thalamic nucleus
Definition
VPL
Term
DCML travels through two fasciculi starting at what vertebral level
Definition
T5/T6
Term
Decerebrate rigidity due to
Definition
No antagonism to the LVST
Term
Decorticate rigidity due to
Definition
Dis-inhibited rubrospinal fibers causes the flexion; damage to cortex excluding motor causes the extension
Term
Decreased osmolality activates what region of the brain
Definition
OVLT
Term
Deep lesion of the cord affects which first: sacral or cervical
Definition
Cervical [different layering for the dorsal columns]
Term
Defect in SHH singalling leading to primitive forebrain failing to diverticulate into two telencephalic vesicles
Definition
Holoprosencephaly
Term
Defective closure of anterior neuropore is
Definition
Anencephaly
Term
Defects in neural crest cells are collectively called
Definition
Neurocristopathies
Term
Dejerine-Roussy syndrome
Definition
Hemianesthesia, dysesthesia, hyperpathia (hurts to put on a shirt)
Term
Dentato-rubro-thalamic pathways connects to which thalamic nucleus
Definition
VL
Term
Descending bulbospinal pathway function
Definition
Modulation of pain by inhibiting pain receptor synapses
Term
Descending bulbospinal pathway through what tract
Definition
Raphespinal tract
Term
Descending loss of pain/termperature, and motor paresis indicates ___ [superficial or deep] lesion
Definition
Deep
Term
Describe anastamoses in the brain
Definition
Limited at the arterial level; nearly none at the arteriolar and capillary level
Term
Describe the layering & connections of the LGN
Definition
Nasal retina to layers 1, 4, 6 & temporal to 2, 3, 5 [pretty sure notes are wrong]
Term
Devastating damage to the thalamus could lead to what condition
Definition
Persistent vegetative state
Term
Direct pathway (4)
Definition
MSN → GPi/SNR → VA → PMCTX
Term
Divisions of the corticobulbospinal system (2)
Definition
1) Corticospinal system, 2) corticobulbar system
Term
Do neurons require insulin for glucose uptake: yes or no
Definition
No
Term
Does MAP vary with activity: yes or no
Definition
Yes
Term
Doll's head maneuver useful for testing VOR in what patients
Definition
Comatose
Term
Dopamine-blocking agents can lead to (2)
Definition
1) Tardiva dyskinesia, 2) akathisia
Term
Dorsal columns contain fibers that are ___ [ipsilateral or contralateral] to what they sense
Definition
Ipsilateral
Term
Dorsal spinocerebellar tract function
Definition
Fine coordination of posture & movement of individual lower limb muscles
Term
Dorsal spinocerebellar tract: ipsilateral or contralateral
Definition
Ipsilateral
Term
During sleep, thalamocortical neurons are in: burst or tonic mode
Definition
Burst
Term
During wakefulness, thalamocortical neurons are in: burst or tonic mode
Definition
Both and TRN selectively puts neurons in tonic mode
Term
Dysphagia almost always accompanies lesions of the
Definition
Medulla
Term
Dystonia etiology
Definition
Lesions at various sites; putamen is most common
Term
Effects of CN III nucleus or nerve lesion (4)
Definition
1) Ipsilateral strabismus, 2) ipsilateral ptosis, 3) ipsilateral mydriasis, 4) ipsilateral loss of light reflexes
Term
Epithalamus primary responsibility
Definition
Circadian rhythms
Term
Error in control of brain cell proliferation on one side leading to larger volume of the hemisphere
Definition
Hemimegalencephaly
Term
Exaggerated deep tendon reflex indicates what
Definition
Lesion/disease of UMN disrupting the LMN inhibition
Term
Examples of neurocristopathies (2)
Definition
1) Cleft palate, 2) Hirschprung's disease
Term
Exogenous causes of brain malformations (6; categories)
Definition
1) Nutritional, 2) radiological, 3) viral, 4) chemical, 5) pharmacological, 6) ischemia
Term
Extremity ataxia from a lesion to: vermis or paravermis
Definition
Paravermis
Term
Eye movements: CBT or reticular CPG's
Definition
Reticular CPG's [CBT does not innervate eye motor nuclei]
Term
Facial nucleus contains ___ [GSA, etc.] neurons for which muscles (4)
Definition
SVE for 1) facial expression, 2) stylohyoid, 3) posterior digastric, 4) stapedius
Term
Facial nucleus lesions can affect facial muscles but can also have what second symptom?
Definition
Hyperacusis from loss of stapedius m.
Term
Fetal alcohol syndrome due to interference with what process
Definition
Neuronal proliferation
Term
First-order neurons are found where
Definition
DRG
Term
Flocculonodular has what function
Definition
Vestibulo-cerebellum: eye movement & body equilibrium
Term
Flocculonodular lobe blood supply
Definition
AICA
Term
Flocculonodular lobe function
Definition
Balance & eye movement
Term
Fluorosis as it relates to spinal stenosis
Definition
Leads to calcification of spinal longitudinal ligaments
Term
Frohlich's syndrome
Definition
Obesity, under-devleoped genitalia, small stature, polydipsia
Term
Frontal lobe primary responsibilities (4)
Definition
1) Intelligence, 2) personality, 3) motivation, 4) motor control
Term
Functional localization is established by
Definition
Modularity
Term
Functions of the basal ganglia
Definition
Learning/retention of complex motor tasks
Term
Gag reflex pathway (4)
Definition
CN IX → NTS → CN X → levator palatini/pharyngeal constrictors/larynx
Term
General influence of nucleus ambiguus on the heart
Definition
Conservative i.e. bradycardia, decreased inotropy
Term
Gestation age in which first sign of nervous system appears
Definition
3 weeks
Term
Ghrelin acts on which arcuate nucleus neurons
Definition
NPY
Term
Ghrelin: short- or long-term signal
Definition
Short-term signal
Term
Great radicular a. serves ___ [anterior or posterior] of the spinal cord
Definition
Anterior
Term
Hemianesthesia: affects which thalamic nuclei (2)
Definition
VPM, VPL
Term
Hemihypoacusis: affects which thalamic nucleus
Definition
MGN
Term
Hemiparesis w/ abnormal movements: affects which thalamic nuclei
Definition
VA, VL, intralaminar
Term
Hiccups: medial or lateral medullary syndrome
Definition
Lateral
Term
Hippocampus primary responsibility
Definition
Spatial memory
Term
Holoprosencephaly defect
Definition
SHH signaling
Term
Horner's syndrome
Definition
Damage to hypothalamospinal pathway above T1
Term
Horner's syndrome: medial or lateral medullary syndrome
Definition
Lateral
Term
How does cerebral blood flow under anemia compare to normal
Definition
Increased with anemia
Term
How does cerebral blood flow under polycythemia compare to normal
Definition
Decreased with polycythemia
Term
How does CO2 affect cerebral blood flow
Definition
Vasodilator ∴ increases flow
Term
How does O2 affect cerebral blood flow
Definition
Drop in O2 increases blood flow
Term
How does pH affect cerebral blood flow (both directions from normal)
Definition
Drop in pH increases blood flow; rise in pH decreases blood flow
Term
How does viscosity affect cerebral blood flow
Definition
Blood flow inversely proportional
Term
How would a lesion to CN VII affect hearing
Definition
Loss of stapedius → hyperacusis
Term
Huntington's disease: loss of direct or indirect pathway
Definition
Indirect [can't not move]
Term
Huntington's has a loss of __ [inhibition or excitation] of the direct pathway
Definition
Inhibition
Term
Huntington's has a loss of __ [inhibition or excitation] of the indirect pathway
Definition
Excitation
Term
Huntington's inheritance
Definition
Autosomal dominant of trinucleotide repeat
Term
Huntington's pathology
Definition
Degeneration of medium spiny striatal neurons that project to external globus pallidus
Term
Huntington's: hypokinetic or hyperkinetic
Definition
Hyperkinetic
Term
Hypersexuality from lesion to __ [medial or lateral] hypothalamus
Definition
Medial
Term
Hypothalamic nucleus involved in circadian rhythms
Definition
Suprachiasmatic
Term
Hypothalamic nucleus involved in endocrine & autonomic systems
Definition
Paraventricular
Term
Hypothalamic nucleus involved in vasopressin/ADH
Definition
Supraoptic
Term
Hypothalamospinal pathway contains
Definition
Mainly autonomics
Term
Hypothalamospinal pathway functions (3)
Definition
1) Thermoregulation, 2) pain modulation, 3) EPI secretion by adrenals
Term
Hypothalamus integrates what (3)
Definition
1) Autonomic, 2) endocrine, 3) limbic
Term
Idiopathic torsion dystonia inheritance
Definition
Autosomal dominant
Term
If the L5-S1 disc herniates, which spinal nerve is usually compressed
Definition
S1 [lumbars are usually the next level down]
Term
Important circumventricular organs (3)
Definition
1) Subfornical organ (SFO) [CSF angiotensin II], 2) organum vasculosum of the lamina terminalis (OVLT) [serum osmolality], 3) median eminence (ME) [he added #3 in lecture]
Term
Increased BP leads to activation of baroreceptors so what "flips" this around to be inhibitory of SNS
Definition
GABA from CVLM to RVLM
Term
Indication a stroke might be cardioembolic
Definition
Multiple strokes in different arterial territories
Term
Indirect pathway (6)
Definition
MSN → GPe → STN → GPi/SNR → VA → PMCTX
Term
Infarcts of the MCA tend to be what shaped
Definition
Pie-slice shaped
Term
Inferior colliculus relays what information
Definition
Auditory
Term
Initial vesicles of the neural tube (3)
Definition
1) Prosencephalon, 2) mesencephalon, 3) rhombencephalon
Term
Initially idiopathic torsion dystonia was thought to be recessive, why
Definition
Incomplete penetrance
Term
Innervation to stapedius m.
Definition
CN VII
Term
Innervation to tensor tympani m.
Definition
CN V3
Term
Insomnia can result from damage to __ [anterior or posterior] hypothalamus
Definition
Anterior
Term
Insula primary responsibilities (4)
Definition
1) Taste & visceral sensation, 2) emotional aspect of pain, 4) biologically significant visual & auditory
Term
Interruption of baroreceptors leads to __ [diminished or exaggerated] cardiovascular responses
Definition
Exaggerated
Term
Intralaminar connects to
Definition
Striatal portions of the basal ganglia
Term
Intralaminar has what general function
Definition
Attention [yes, this card took me 15 minutes to write since I had to vacuum quickly…hmm…]
Term
Intralaminar: sensory, motor, association, limbic, or non-specific
Definition
Non-specific
Term
Ipsilateral loss of pain, temp on face: medial or lateral medullary syndrome
Definition
Lateral
Term
Is bilateral stroke to temporal lobe necessary — or unilateral sufficient — to profoundly affect speech interpretation
Definition
Bilateral necessary
Term
Jaw-jerk reflex pathway
Definition
Afferents → mesencephalic nucleus → motor nucleus of V → mm. of mastication (masseter?)
Term
Jet lag, sleep, and seasonal affective disorders (SAD) are due in part to
Definition
Disruption of melatonin cycle
Term
Kallmann's syndrome
Definition
Anosmia, hypogonadism, delayed puberty
Term
Kernicterus
Definition
Yellow staining of brain from unconjugated bilirubin
Term
Key nucleus in food intake behavior
Definition
Arcuate nucleus
Term
Kleine-Levin syndrome
Definition
Hyperphagia, hypersexuality, amnesia, hypersomnolence, episodic paranoia
Term
Know the lesions of the optic nerve, tract, & chiasm: see HOS notes
Definition
Know the lesions of the optic nerve, tract, & chiasm: see HOS notes
Term
Korsakoff's syndrome affects what areas
Definition
Anterior group, LD, mammillary bodies, fornix, MTT, cingulate & retrosplenial cortices
Term
Lacunar strokes formed from penetrating branches of (5)
Definition
1) MCA, 2) anterior choroidal, 3) PCA, 4) posterior communicating, 5) basilar
Term
Lateral hemispheres have what function
Definition
Planning, initiation, & timing of movements [cerebro-cerebellum]
Term
Lateral hypothalamic lesions lead to: aphagia or hyperphagia
Definition
Aphagia
Term
Lateral Medullary Syndrome aka (2)
Definition
PICA, Wallenberg's
Term
Lateral medullary syndrome: CN V
Definition
Ipsilateral loss of pain, temp on face
Term
Lateral medullary syndrome: descending SNS tract
Definition
Horner's syndrome
Term
Lateral medullary syndrome: inferior cerebellar peduncle
Definition
Ipsilateral ataxia
Term
Lateral medullary syndrome: nucleus ambiguus
Definition
Dysphagia, displaced uvula, flaccid vocal fold
Term
Lateral medullary syndrome: reticular formation
Definition
Hiccups
Term
Lateral medullary syndrome: spinothalamic tract
Definition
Contralateral loss of pain, temp over body
Term
Lateral medullary syndrome: vestibular nuclei
Definition
Vertigo & nausea
Term
Lateral superior olive: time of arrival or intensity discrimination
Definition
Intensity
Term
Lateropulsion can occur in a lesion to what tract
Definition
Spinocerebellar tract
Term
LD connects to what (2)
Definition
1) Parahippocampal region to fornix, 2) retrosplenial cortex
Term
LD: sensory, motor, association, limbic, or non-specific
Definition
Limbic
Term
Leading research treatment for idiopathic torsion dystonia
Definition
RNA interference to silence gene
Term
Learning and memory are derived from what processes (3)
Definition
1) Formation of new synaptic contacts, 2) permanent alterations in synaptic efficiency, 3) generation of new cells
Term
Leptin acts on which arcuate nucleus neurons
Definition
POMC [inhibits NPY neurons too]
Term
Leptin: short- or long-term signal
Definition
Long-term signal
Term
Lesion at what level results in reflex/spastic bowel & bladder
Definition
T12 [loss of SNS, PSNS, somatomotor control]
Term
Lesion of the spinothalamic tract at, say, T12 would manifest to what level
Definition
L1-2 because of Lissauer's tract
Term
Lesion of which corticospinal motor neuron with exhaggeration of deep tendon reflex: upper or lower motor neuron
Definition
Upper motor neuron
Term
Lesion of which corticospinal motor neuron with loss of deep tendon reflex: upper or lower motor neuron
Definition
Lower motor neuron
Term
Lesion to abducens nucleus is what palsy
Definition
Lateral gaze palsy on ipsilateral side [the direction unable to gaze toward]
Term
Lesion to basal pons affects CST & CBT bilaterally, name syndrome
Definition
Locked-in syndrome
Term
Lesion to CN VI is what palsy
Definition
Lateral rectus palsy on ipsilateral side
Term
Lesion to pons MLF is what palsy
Definition
Internuclear ophthalmoplegia: failed adduction on ipsilateral side & abducting nystagmus on contralateral side
Term
Lesion to pontine micturition center leads to urine ___ [retention or incontinence]
Definition
Urinary retention
Term
Lesion to the lateral lemniscus: ipsilateral or contralateral hearing loss
Definition
Contralateral [although some stay ipsilateral, but contralateral dominance]
Term
Lesions affecting the brainstem midline will usuaually also affect what
Definition
General somatic efferent motorneurons
Term
Lesions affecting the lateral brainstem will usuaually also affect what
Definition
Branchiomotor nuclei
Term
Lesions of MD result in (3)
Definition
1) Apathy, 2) memory changes, 3) perseveration [difficulty task switching]
Term
Lesions of the central tegmental tract can lead to
Definition
Horner's syndrome
Term
Lesions to abducens nucleus often damages ___ fibers
Definition
CN VII fibers
Term
Lesions to basal ganglia will have __ [contralateral or ipsilateral] effects on motor function
Definition
Contralateral [I don't get how CST decussation is involved here….]
Term
Lesions to cerebellum will have __ [contralateral or ipsilateral] effects on motor function
Definition
Ipsilateral [I don't get how CST decussation is involved here….]
Term
Lesions to coritcospinal lower motor neurons usually manifest as
Definition
Weakness/paresis/paralysis, abolished/weak deep tendon reflexes, muscle atrophy, hypotonia, fasciculation
Term
Lesions to corticospinal upper motor neurons usually manifest as
Definition
Paresis and loss of inhibitory influence (hypertonia, spasticity, hyperreflexia, Babinski sign)
Term
Lesions to lateral & posterior hypothalamus may result in changes to
Definition
Behavior
Term
Lesions to VLPO results in: insomnia or profound state of sleepiness
Definition
Insomnia
Term
LGN connects to which part of the cortex
Definition
Primary visual areas on the banks of the calcarine fissure
Term
LGN: sensory, motor, association, limbic, or non-specific
Definition
Sensory
Term
LH/PF is __ [active or inactive] during sleep
Definition
Inactive
Term
LH/PF neurons use which neurotransmitter
Definition
Orexin
Term
Limbic lobe primary responsibilities (4)
Definition
1) Emotions, 2) basic drives, 3) smell, 4) memory
Term
Limbic nuclei of the thalamus (2)
Definition
Anterior group, LD
Term
Lissencephaly
Definition
Smooth brain from lack of sulci
Term
Longitudinal arteries of the spinal cord (3)
Definition
1) Anterior spinal medullary a., 2-3) posterior spinal aa.
Term
Loss of excitation of direct pathway: Parkinson's or Huntington's
Definition
Parkinson's
Term
Loss of excitation of indirect pathway: Parkinson's or Huntington's
Definition
Huntington's
Term
Loss of inhibition of direct pathway: Parkinson's or Huntington's
Definition
Huntington's
Term
Loss of inhibition of indirect pathway: Parkinson's or Huntington's
Definition
Parkinson's
Term
Lower limb equivalent of the cuneocerebellar tract
Definition
Dorsal spinocerebellar tract
Term
Lower-face LMN of the facial nucleus receives __ [unilateral or bilateral] input from UMN
Definition
Unilateral and is contralateral
Term
Main site in which anesthetics have unconscious effect
Definition
Thalamus
Term
Major modalities of somatic sensation (4)
Definition
1) Discriminative touch, 2) proprioception, 3) temperature, 4) nociception
Term
Major motor pathways of the corticobulbarspinal system (2)
Definition
1) Corticospinal, 2) corticobulbar
Term
Major motor pathways we care about up to this point (3)
Definition
1) Corticobulbarspinal, 2) hypothalamospinal, 3) raphespinal
Term
Major sensory pathways (5)
Definition
1) Spinothalamic, 2) trigeminothalamic, 3) DCML, 4) dorsal spinocerebellar, 5) ventral spinocerebellar
Term
Major types of ischemic stroke (4)
Definition
1) Atherothrombotic, 2) cardioembolic, 3) lacunar stroke, 4) "other"
Term
Mammillothalamic tract connects
Definition
Anterior group to mammillary bodies
Term
MCA/ACA watershed stroke covers what semsory & motor homunculus area
Definition
Proximal limb muscles
Term
MD connects to which parts of the cortex (2)
Definition
Frontal & orbital cortices
Term
MD: sensory, motor, association, limbic, or non-specific
Definition
Association
Term
Medial hypothalamic lesions lead to: aphagia or hyperphagia
Definition
Hyperphagia
Term
Medial Medullary Syndrome aka (2)
Definition
Dejerine's, Anterior Spinal Artery Syndrome
Term
Medial medullary syndrome: Medial Lemniscus
Definition
Contralateral loss, 2-point discrimination, vibration, kinesthesia
Term
Medial medullary syndrome: motor
Definition
Contralateral UMN signs that spares the face [facial nucleus in pons]
Term
Medial medullary syndrome: tongue
Definition
Ipsilateral LMN signs: protruded tongue toward affected side
Term
Medial superior olive: time of arrival or intensity discrimination
Definition
Time of arrival
Term
Medial vestibulospinal pathway ends where
Definition
Mid-thoracic levels
Term
Melatonin __ [inhibits or activates] insulin release
Definition
Inhibits
Term
Melatonin is secreted during: day or night
Definition
Night
Term
Memory impairment: affects which thalamic nuclei
Definition
Anterior group, MD
Term
Metachromatic leukodystrophy
Definition
Failure to form myelin; progressive weakness, blindness, hypotonia, & dementia during childhood
Term
Ménière's disease
Definition
Excess endolymph
Term
MGN connects to which non-cortex structure
Definition
Inferior colliculus
Term
MGN connects to which part of the cortex
Definition
Auditory cortex in Heschl's gyrus
Term
MGN: sensory, motor, association, limbic, or non-specific
Definition
Sensory
Term
Midline cerebellar syndrome (aka archicerebellar syndrome)
Definition
Truncal ataxia & nystagmus [medulloblastoma on vermis]
Term
Midline has what general function
Definition
General cortical arousal
Term
Midline receives what information
Definition
Pain from periaqueductal gray
Term
Midline: sensory, motor, association, limbic, or non-specific
Definition
Non-specific
Term
(type of lesion + symptoms)
Definition
Caudal basal pontine lesion → CN VI & VII + CST damage → crossed hemiplegia + ipsilateral LMN signs in head + contralateral LMN signs in body
Term
Millard-Grubber syndrome is an example of ___ syndromes
Definition
Basal pontine syndromes
Term
Molecular basis of ischemic injury
Definition
Mitochondrial injury → free radicals → cell membrane injury → leukotrienes, leukocyte activation → cell death
Term
Most common cause of intracerebral hemorrhage
Definition
Hypertension (60%)
Term
Most common cause of subarachnoid hemorrhage
Definition
Cerebral aneurysm
Term
Most common disc herniation sites (3)
Definition
1) C6-7, 2) L4-5, 3) C6-7
Term
Most of L-DOPA is decarboxylated peripherally: solution
Definition
Increase dose [this is why first use of L-DOPA was ineffective: too low of a dose]
Term
Motor nuclei of the thalamus (2)
Definition
VA, VL [all of the 2-letter ventral nuclei]
Term
Motor nucleus of V contains neurons for which muscles (5)
Definition
1) Mastication, 2) tensor tympani, 3) tensor veli palatini, 4) mylohyoid, 5) anterior digastric
Term
Munro-Kellie doctrine
Definition
Increased intracranial volume → increased intracranial pressure
Term
Mutliple sclerosis
Definition
Inflammatory demyelination of the CNS
Term
Name for the weak supply from C8-T9
Definition
Watershed zone
Term
NE: increases or decreases feeding
Definition
Increases
Term
Neural tube defect examples (2)
Definition
1) Anencephaly, 2) spina bifida
Term
Neurocristopathies
Definition
Defects in neural crest cells
Term
Neuropeptide Y is: orexigenic or anorexigenic
Definition
Orexigenic
Term
Neurosyphilis can cause
Definition
Posterior cord syndrome from DRG cell death & demyelination in dorsal columns
Term
Newer treatments for Parkinson's (2)
Definition
1) COMT inhibitors, 2) GAD gene therapy
Term
Non-motor functions of the cerebellum (3)
Definition
1) Autonomic, 2) behavior/mood, 3) cognition/memory
Term
Non-specific nuclei of the thalamus (2)
Definition
Midline, intralaminar [both are midline nuclei]
Term
Nuclei in the medulla (4; lateral to medial)
Definition
1) Mesencephalic, 2) Edinger-Westphal, 3) oculomotor, 4) trochlear
Term
Nuclei in the medulla (7; lateral to medial)
Definition
1) Vestibulocochlear, 2) main sensory of trigeminal, 3) solitarius, 4) inferior salivatory, 5) dorsal motor vagal, 6) ambiguus, 7) hypoglossal
Term
Nuclei in the pons (9; lateral to medial)
Definition
1) Vestibulocochlear, 2) mesencephalic, 3) spinal trigeminal, 4) main sensory of trigeminal, 5) solitarius, 6) superior salivatory, 7) motor trigeminal, 8) facial, 9) abducens
Term
Nucleus ambiguus innervates what muscles and via what CN's
Definition
Pharynx, larynx, soft palate & upper esophagus via CN IX & X
Term
Occipital lobe primary responsibility
Definition
Vision
Term
Of both pathways, which connections are excitatory (2)
Definition
1) VA → PMCTX, 2) STN → GPi/SNR
Term
Of both pathways, which connections are inhibitory (4)
Definition
1) MSN → GPi/SNR, 2) GPi/SNR → VA, 3) MSN → GPe, 4) GPe → STN
Term
One possible treatment for intractable visceral pain
Definition
Dorsal column lesions
Term
One sign of spinocerebellar lesion
Definition
Lateropulsion
Term
Onuf's nucleus is found at what spinal cord levels
Definition
S1-4
Term
Osmotic thirst enters MPOA via the
Definition
OVLT
Term
Pachygyria
Definition
Thick brain from broad gyri
Term
Paravermis has what function
Definition
Execution of trunk & limb movements [spino-cerebellum]
Term
Paravermis: trunk or extremities
Definition
Exremities
Term
Parietal lobe primary responsibilities (3)
Definition
1) General sensation, 2) language, 3) spatial orientation
Term
Parkinson's clinical features (3)
Definition
1) Bradykinesia (abnormal slowness of movement), 2) hypertonia (spasticity), 3) aboulia (diminished motivation)
Term
Parkinson's disease: loss of direct or indirect pathway
Definition
Direct [can't move very well]
Term
Parkinson's etiology
Definition
Environmental & genetic (autosomal dominant or recessive forms)
Term
Parkinson's has a loss of __ [inhibition or excitation] of the direct pathway
Definition
Excitation
Term
Parkinson's has a loss of __ [inhibition or excitation] of the indirect pathway
Definition
Inhibition
Term
Parkinson's is usually: symmetric or asymmetric
Definition
Asymmetric
Term
Parkinson's pathology: loss of __ (4)
Definition
1) Dopaminergic in substantia nigra, 2) cholinergic in cortex, 3) cholinergic in brainstem, 4) serotonergic in brainstem
Term
Parkinson's prevalence
Definition
200 in 100,000
Term
Parkinson's: hypokinetic or hyperkinetic
Definition
Hypokinetic
Term
Patellar reflex test what spinal cord segments
Definition
L3-4
Term
Penumbra
Definition
Area arounda region of ischemia
Term
Periaqueductal gray functions (2)
Definition
1) Analgesia, 2) adaptive behaviors
Term
Phrenic nucleus is found at what spinal cord levels
Definition
C3-5
Term
Pineal cyst can lead to
Definition
Vertical gaze paralysis
Term
Pneumotaxic center ___ [inhibits or drives] inspiration
Definition
Inhibits apneustic center ∴ inhibits inspiration
Term
Polymicrogyria
Definition
Numerous small abnormal gyri with shallow/absent sulci
Term
POMC is: orexigenic or anorexigenic
Definition
Anorexigenic
Term
Pontine micturition center is __ [inhibited or activated] on a full bladder
Definition
Activated
Term
Pontine storage center ___ [inhibits or activates] destrusor m.
Definition
Inhibits
Term
Pontine storage center ___ [inhibits or activates] Onuf's nucleus
Definition
Disinhibits → activates
Term
Possible effects of a lesion in red
Definition
1) Loss of pain & temp over left arm, 2) UMN signs in right forearm & hand, 3) LMN signs in right deltoid & biceps
Term
Possible effects of a lesion in red
Definition
1) Loss of pain & temp over left leg & abdomen, 2) UMN signs in right foot & leg, 3) bowel & bladder problems
Term
Possible result of head trauma that damages the supraoptic nucleus
Definition
Diabetes insipidus
Term
Possible vision change due to pituitary tumors
Definition
Bitemporal hemianopsia ["tunnel vision"]
Term
Posterior cord syndrome symptoms (2)
Definition
1) Loss of 2-point discrimination & kinesthesia, 2) Romberg sign
Term
Posterior hypothalamus lesions lead to __ [hypo- or hyperthermia] due to loss of __ [MPOA or DMH]
Definition
Hypothermia due to loss of DMH
Term
Posterior lobe blood supply
Definition
PICA & AICA (ventral)
Term
Posterior lobe function
Definition
Motor & non-motor [so….everything?]
Term
Posterior spinal arteries supply what structures (4)
Definition
1) Dorsal columns, 2) posteromarginal nucleus, 3) substantia gelatinosa, 4) nucleus proprius
Term
Postural movement involves what kind of movements
Definition
Upright posture, mainly extensors
Term
Premotor cortex does what
Definition
Plans movement; includes mirror neurons
Term
Preoptic nuclei
Definition
Thermoregulation, salt water intake, & sleep
Term
Pretectal neurons innervate the contralateral Edinger-Westphal nucleus by decussating where
Definition
Posterior commissure
Term
Primary motor cortex in what gyrus
Definition
Precentral gyrus
Term
Primary sensory cortex in what gyrus
Definition
Postcentral gyrus
Term
Profound state of sleepiness can result from damage to __ [anterior or posterior] hypothalamus
Definition
Posterior
Term
Pseudobulbar palsy
Definition
UMN defect in CN V, VII, IX, XII with inappropriate laughter & crying
Term
PSNS & somatomotor control of bowel/bladder is loacted where
Definition
Conus medullaris (S2-5)
Term
PSNS activation may have a ___ [harmful or protective] effect on brain ischemia
Definition
Protective
Term
Pulvinar connects to which parts of the cortex
Definition
Um, all of them: multimodal areas in parietal, temporal & occipital lobes; cingulate & frontal cortices
Term
Pulvinar: sensory, motor, association, limbic, or non-specific
Definition
Association
Term
Pyrogens __ [inhibit or activate] the __ [MPOA or DMH] through __ [which chemicals]
Definition
Pyrogens inhibit MPOA through prostaglandins (PGE2) on the EP3 receptor
Term
Raymond-Cestan is an example of ___ syndromes
Definition
Tegmental pontine syndromes
Term
Raymond-Cestan syndrome
Definition
CN VI & conjugate gaze palsies, dysarthria, contralateral hemianesthesia+hemiplegia
Term
Reasons the spinal cord is not damaged during normal movement of the vertebrae (3)
Definition
1) Central position within canal, 2) epidural fat, CSF, & meninges, 3) dural sheaths & denticlate ligaments
Term
Romberg's test
Definition
Standing feet together, arms at side: close eyes → sways/falls if dorsal column lesion
Term
Rostral basis pontis lesions would affect what structures (4)
Definition
1) CST, 2) CBT, 3) CN VI, 4) CN VII
Term
Rostral tegmental lesions would affect what structures (4)
Definition
1) MLF, 2) medial lemniscus, 3) superior cerebellar peduncle, 4) spinal lemniscus
Term
Rubrospinal pathway function
Definition
Neck & upper limb flexors
Term
Second-order neurons are found where
Definition
Segment of spinal cord gray matter or in the brain stem
Term
Sensory nuclei of the thalamus (6)
Definition
VPM, VPMpc, VPL, VPI, LGN, MGN [all of the 3-letter ventral nuclei plus geniculates]
Term
Separate pathways of the spinocerebellar pathway (3)
Definition
1) Dorsal spinocerebellar tract, 2) cuneocereellar tract, 3) ventral spinocerebellar tract
Term
Septo-optic dysplasia has absence of what structure
Definition
Septum pellucidum
Term
Serotonin: increases or decreases feeding
Definition
Decreases
Term
Should a lumbar puncture be performed on patients with increasd intracranial pressure: yes or no
Definition
No
Term
Side of vertebral disc most likely to herniate
Definition
Posterolateral edge
Term
Signs of corticospinal LMN lesions (6)
Definition
1) Paralysis, 2) paresis, 3) hypotonia, 4) hyporeflexia/areflexia, 5) fasciculations, 6) muscle atrophy
Term
Signs of corticospinal UMN lesions (6)
Definition
1) Paresis, 2) spasticity, 3) hyperreflexia, 4) clonus, 5) abnormal superficial reflexes, 6) Babinski
Term
Signs of temporal lobe seizures (3)
Definition
1) Tinnitus, 2) auditory "hallucinations", 3) vertigo
Term
Smooth pursuit mediated by what structure
Definition
Flocculus of the cerebellum
Term
SNS control of bowel/bladder is loacted where
Definition
T12-L2
Term
Some spinal tracts (e.g., lateral corticospinal tract) are ordered (superficial to deep): sacral-to-cervical or cervical-to-sacral
Definition
Sacral (superficial) to cervical (deep)
Term
Spinal accessory nucleus is found at what spinal cord levels
Definition
C1-5
Term
Spinal cord levels in which lateral horn is present
Definition
T1-L2
Term
Spinothalamic tract decussates where
Definition
Spinal cord
Term
Spinothalamic tract to which thalamic nucleus
Definition
VPL
Term
Spondylosis
Definition
Arthritic degeneration, new bone growth into spinal canal
Term
Static labyrinth detects: linear or angular acceleration
Definition
Linear [I don't recall these two terms from HOS]
Term
Steal syndrome
Definition
Prolonged ischemia causes blood flow away from high [CO2]
Term
Stereotypic movement involves what kind of movements
Definition
Hard-wired that are present at birth
Term
Stroke
Definition
Injury caused by interruption of blood flow
Term
Strokes in PCA tends to result in
Definition
Visual deficits
Term
Subarachnoid hemorrhage changes CSF how
Definition
Yellowish color
Term
Summary of medial hypothalamic lesion (4)
Definition
1) Obese, 2) rage, 3) hypersexual, 4) hyperphagic
Term
Superficial lesion of the cord affects which first: sacral or cervical
Definition
Sacral [different layering for the dorsal columns]
Term
Superior colliculus relays what information
Definition
Movement of eyes & head in response to visual, auditory, & somatic stimuli
Term
Suprachiasmatic nucleus
Definition
Circadian rhythms
Term
Supraoptic nucleus releases
Definition
Vasopressin/ADH
Term
Syringomyelia
Definition
Syrinx formed in cervical/thoracic cord that destroys ventral white commissure and, possibly, lateral corticospinal tract
Term
Syringomyelia symptoms (3)
Definition
1) Bilateral loss of pain & temperature over shoulder & lateral arm, 2) possible CN XI damage, 3) possible phrenic nucleus damage
Term
Tardive dyskinesia
Definition
Involuntary movement of mouth & tongue
Term
Taste from solitary tract to which thalamic nucleus
Definition
VPMpc
Term
Tegmental pontine syndrome symptoms (general)
Definition
Ipsilateral CN signs with contralateral sensory body signs
Term
Temporal lobe primary responsibilities (4)
Definition
1) Hearing, 2) language processing, 3) visual processing, 4) memory
Term
Terminal branches of the internal carotid artery (2)
Definition
1) Anterior cerebral a., 2) middle cerebral a.
Term
Thalamus process what going to and from the cerebrum
Definition
Sensory & motor information
Term
Third-order neurons are found where
Definition
Thalamus
Term
Thrombus for an atherothrombotic stroke formed how
Definition
Atherosclerotic plaque opens causing platelet aggregation
Term
TIA
Definition
Sudden onset of a focal neurologic deficit that is brief
Term
Triceps reflex test what spinal cord segments
Definition
C7-8
Term
Trigeminal lemniscus to which thalamic nucleus
Definition
VPM
Term
Trochlear nerve lesion symptoms
Definition
Ipsilateral SO m. paralysis; tilts head toward non-lesioned side
Term
Truncal ataxia from a lesion to: vermis or paravermis
Definition
Vermis
Term
Types of hemorrhagic stroke (2)
Definition
1) Intracerebral, 2) subarachnoidal
Term
Types of movements (3)
Definition
1) Voluntary, 2) sterotypic, 3) postural
Term
Types of stroke (2)
Definition
1) Ischemic, 2) hemorrhagic
Term
Uncal herniation: decerebrate or decorticate regidity
Definition
Decerebrate
Term
Unescapable cardiac stresses can lead to
Definition
Sudden cardiac death
Term
Upper limb equivalent of the dorsal spinocerebellar tract
Definition
Cuneocerebellar tract
Term
Upper limb equivalent of the ventral spinocerebellar tract
Definition
None known in humans
Term
Upper-face LMN of the facial nucleus receives __ [unilateral or bilateral] input from UMN
Definition
Bilateral
Term
VA connects to which non-cortex structure
Definition
Basal ganglia [lot's of A's in "basal ganglia"]
Term
VA connects to which parts of the cortex (2)
Definition
Medial=substantia nigra; lateral=trunk & limb regions of the premotor cortex
Term
VA: sensory, motor, association, limbic, or non-specific
Definition
Motor
Term
Ventral spinocerebellar tract function
Definition
Whole lower limb posture & movement
Term
Ventral spinocerebellar tract: ipsilateral or contralateral
Definition
Ipsilateral but through a double decussation
Term
Vermis has what function
Definition
Muscle tone & posture [spino-cerebellum]
Term
Vermis: trunk or extremities
Definition
Trunk
Term
Vertigo & nausea: medial or lateral medullary syndrome
Definition
Lateral
Term
Vertigo, trunk ataxia, & nausea result from damage to (2)
Definition
1) Semicircular canals & static labyrinth, 2) vesibular & cochlear nuclei
Term
Vestibulo-collic reflexes (VCR)
Definition
Stabilize head
Term
Vestibulo-ocular reflex: excitatory from S. or M. vestibular nucleus
Definition
Medial vestibulospinal nucleus
Term
Vestibulo-ocular reflex: inhibitory from S. or M. vestibular nucleus
Definition
Superior vestibulospinal nucleus
Term
Vestibulo-ocular reflex: nuclei involved (4)
Definition
1-2) S. & M. vestibular nuclei, 3) abducens, 4) oculomotor
Term
Vestibulo-ocular reflexes (VOR)
Definition
Stable vision during head motion
Term
Vestibulo-spinal reflexes (VSR)
Definition
Response to tripping
Term
Visceral pain feels like skin pain because
Definition
Both first-order neurons innervate on the same second-order neuron
Term
VL connects to which non-cortex structure
Definition
Cerebellum [lots of L's in "cerebellum"]
Term
VL connects to which part of the cortex
Definition
Motor cortex (area 4) in pre-central gyrus
Term
VL: sensory, motor, association, limbic, or non-specific
Definition
Motor
Term
VLPO is __ [active or inactive] during sleep
Definition
Active
Term
Volumetric thirst enters MPOA via the
Definition
SFO
Term
Voluntary movement involves what kind of movements
Definition
Willed, purposeful & factionated
Term
VPI connects to which part of the cortex
Definition
Inferior parietal lobule
Term
VPI: sensory, motor, association, limbic, or non-specific
Definition
Sensory
Term
VPL connects to which part of the cortex
Definition
Non-face parts of the post-central gyrus
Term
VPL: sensory, motor, association, limbic, or non-specific
Definition
Sensory
Term
VPM connects to which part of the cortex
Definition
Face area of post-central gyrus
Term
VPM: sensory, motor, association, limbic, or non-specific
Definition
Sensory
Term
VPMpc connects to which part of the cortex
Definition
Anterior part of insula (primary gustatory area)
Term
VPMpc: sensory, motor, association, limbic, or non-specific
Definition
Sensory
Term
We finally know why loss of CST leads to hyperreflexia because
Definition
Loss of inhibition of interneurons
Term
Weber's syndrome
Definition
CN III palsy & contralateral UMN paralysis (CST & CBT)
Term
Weber's syndrome etiology
Definition
Lesion to basal midbrain
Term
What causes the pain of a herniated disc (2)
Definition
1) Chemical radiculitis, 2) disc & periosteal nociceptors
Term
What does more oligoclonal bands in CSF than blood serum indicate
Definition
Ig's in CNS ∴ autoimmune disease (e.g., MS)
Term
What is absent in patients with narcolepsy
Definition
Orexin
Term
What is this syndrome
Definition
CN III nucleus or nerve lesion
Term
What joins the ACA's at the optic chiasm
Definition
Anterior communicating artery
Term
What motor goes through the thalamus
Definition
All motor & movement-related information that involves the cortex
Term
What pathway is depicted
Definition
Corticospinal tract
Term
What sensory goes through the thalamus
Definition
All but olfactory & emotion aspects of pain
Term
What two systems affect the corticobulbarspinal system
Definition
1) Cerebellum [error correction], 2) basal ganglia [patterned learning]
Term
When does myelination begin
Definition
Third trimester
Term
When does SNS activity become important to cerebral blood flow
Definition
When outside compensatory range of autoregulation
Term
Where are most disturbances in hearing
Definition
Middle & inner ear
Term
Where do anterior corticospinal fibers decussate
Definition
Ventral white commissure of the spinal cord
Term
Where do dopaminergic neurons originate
Definition
SNC
Term
Where is swallowing found in the medulla
Definition
Between the NTS & nucleus ambiguus
Term
Where is the vertical gaze center
Definition
Rostral midbrain
Term
Which affects proximal extermities: ballism or chorea
Definition
Ballism
Term
Which area of sensory & motor homunculus is covered by the ACA
Definition
Hips and inferiorly
Term
Which area of sensory & motor homunculus is covered by the MCA
Definition
Hips and superiorly
Term
Which carries proprioception: ventral or dorsal trigeminothalamic tract
Definition
Neither
Term
Which circumventricular organ is sensitive to CSF angiotensin II
Definition
SFO
Term
Which circumventricular organ is sensitive to serum osmolality
Definition
OVLT
Term
Which circumventricular organ is the site in which paraventricular neurons release their releasing hormones
Definition
ME
Term
Which comes first: dopamine or movement
Definition
Dopamine
Term
Which contains contralateral sensation: ventral or dorsal trigeminothalamic tract
Definition
Ventral trigeminothalamic tract
Term
Which contains ipsilateral sensation: ventral or dorsal trigeminothalamic tract
Definition
Dorsal trigeminothalamic tract
Term
Which degenerates in Parkinson's: SNR or SNC
Definition
SNC
Term
Which facilitates movement: direct or indirect
Definition
Direct
Term
Which hair cells can be damaged by excessively loud sounds & drugs
Definition
Outer hair cells
Term
Which inhibits movement: direct or indirect
Definition
Indirect
Term
Which is more dorsal in the ventral horn: flexors or extensors
Definition
Flexors
Term
Which is more lateral in the ventral horn: truck or limb muscles
Definition
Limb muscles
Term
Which is more medial in the ventral horn: truck or limb muscles
Definition
Trunk muscles
Term
Which is more ventral in the ventral horn: flexors or extensors
Definition
Extensors
Term
Which pathway for conscious proprioception
Definition
DCML
Term
Which pathway for discriminative touch
Definition
DCML
Term
Which pathway for fractionated hand movement
Definition
Corticospinal system
Term
Which pathway for itch
Definition
Spinothalamic tract
Term
Which pathway for non-conscious proprioception
Definition
Spinocerebellar tract
Term
Which pathway for pain
Definition
Spinothalamic tract
Term
Which pathway for temperature
Definition
Spinothalamic tract
Term
Which pathway for tickle
Definition
Spinothalamic tract
Term
Which pathway for visceral pain
Definition
DCML
Term
Which pathway for voluntary movement
Definition
Corticobulbospinal system
Term
Which respiratory group is sensitive to CO2
Definition
Ventral respiratory group
Term
Which side is most likely to have a stroke: left or right
Definition
Left
Term
Which spinal artery affects the cord bilaterally
Definition
Anterior spinal artery
Term
Which spinal artery affects the cord unilaterally
Definition
Posterior spinal artery
Term
Which stabilizes head/eyes/neck to posture changes: medial or lateral vestibulospinal tract
Definition
Medial vestibulospinal tract
Term
Which stabilizes posture: medial or lateral vestibulospinal tract
Definition
Lateral vestibulospinal tract
Term
Which syndrome is more dorsal (right circle)
Definition
Benedikt's syndrome
Term
Which syndrome is more ventral (left circle)
Definition
Weber's syndrome
Term
Which thalamic nuclei connect to the post-central gyrus
Definition
VPM & VPL
Term
Which tract has a double decussation
Definition
Ventral spinocerebellar tract [once in spinal cord, the other in pons]
Term
Which type of movement is coordination of eyes, head, nceck, saccades
Definition
Postural
Term
Which type of movement is dominated by vestibular system
Definition
Postural
Term
Which type of movement is fractionated
Definition
Voluntary
Term
Which type of movement is present at birth
Definition
Stereotypic
Term
Which type of movement is purposeful
Definition
Voluntary
Term
Which type of stroke: subarachnoid or intracerebral
Definition
Subarachnoid
Term
Which type of stroke: subarachnoid or intracerebral
Definition
Intracerebral
Term
Why do individual muscles span multiple spinal levels
Definition
LMN's are in columns [that just so happen to span multiple levels]
Term
Why doesn't damage to primary auditory cortex necessarily lose reflexes
Definition
Reflex processing is not in cerebral cortex
Term
Why don't lesions of the spinocerebellar tract produce obvious signs
Definition
Goes to cerebellum [← non-conscious proprioception]
Term
Why L-DOPA instead of just dopamine
Definition
Dopamine does not cross blood-brain barrier
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