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Neurological Disorders
Tumors, Seizure Disorders, Cerebrovascular Accidents, Disorders of Development, Degenerative Disorders,Disorders Caused by Infectous Diseases
38
Psychology
Graduate
04/01/2012

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Term
tumor
Definition
a mass of cells whose growth is uncontrolled and serves no useful function
Term
malignant
Definition
a cancerous tumor, lacking a distinct border and may metastasize. its infiltrating the surrounding tissue, so if cut out some cell may be left behind
Term
benign
Definition
a non-cancerous tumor, has a distinct border and cannot metatasize
Term
metastasis
Definition
happens often with malignant tumors. The process by which cells break off a tumor, ravel through the vascular system, and grow elsewhere in the body
Term
2 ways tumors damage brain tissue
Definition
compression and infiltration
Term
where do tumors arise from?
Definition
They do not arise from neurons, they arise from other cells found in the brain or from metastases originating elsewhere in the body
Term
gliomas
Definition
a cancerous brain tumor composed of one of several types of glia cells, one of the msot serious types of tumors, fast growing and very malignant
Term
meningioma
Definition
a benign bain tumor composed of the cells that constitute the meninges
Term
treatment of tumors
Definition
removal, radiation therapy, chemotherapy, steroids, others
Term
seizure disorder
Definition
aka epilepsy, when a person has seizure, or a priod of sudden excessive activity o cerebral neurons, can have many causes, 2% of population will have at least 1 seizure,
Term
convulsion
Definition
a violent sequnce of uncontrollable muscle movements caused by a seizure. Most seizures, in fact, don't cause convulsions.
Term
types of seizures
Definition
partial vs. generalized. Two categories of partial are simple or complex.
Term
partial seizures
Definition
have a definite focus and remains localized, not generalized to rest of brain (typically the focus is a scarred region cased by an old injury, or a developmntal abnormality like a malformed bloo vessel)
Term
generalized seizures
Definition
a seizure that involves most of brain. They may grow from one focus or sometimes origin is not disocvered.
Term
simple partial seizure
Definition
a partial seizure that does not produce a loss of conciousness.Can be motor, somatosensory, autonomic, psychic, cognitive or affective
Term
complex partial seizure
Definition
a partial seizure that produces loss of consciousness. Can be convulsive or non-convulsive.
Term
tonic-clonic seizure
Definition
aka grand mal seizure. A generalized seizure which results in convulsions.
Term
aura
Definition
a sensation that prcedes a seizure, its exact nature depends on the location of the seizure focus. Can be an iternal sensaton, visual or motor changes, etc
Term
tonic phase
Definition
The first phase of a tonic-clonic seizure, in which all of the person's skelatal muscles are contracted. Th person is completely unconsious at this point and holds the rigid posture for about 15 seconds
Term
clonic phase
Definition
The phase of a tonoc clonic seizure in which the person shows rhythmic jerking movements. Eyes roll, person's face in contourted in grimaces, tongue may be bitten, sweating, salivation. After seisure can show confuson, drowsiness, headache and muscle soreness.
Term
percentage of those with elilepy that have temportal lope epilepsy with damage to hippocampus
Definition
25% of kids and 50% of adults
Term
absence seizures
Definition
a type of seizure disorder often seen in children, characterized by periods of inattention, which are not remembered, called petit mal seizures
Term
status epilepticus
Definition
a condition in which the person undrgoes a series of seizures without regaining consiousness. even one episode like this can caue significant hippocampal damage.
Term
causes of seizures
Definition
common cause is scarring from an injury, stroke, developmental abnormality in brain, or tumor. Other causes include various drugs and infections that causes high fever, or when aloholics or drug addicts stop taking the drug,
Term
treatment of seizure disorder
Definition
medications which increase inhibition (soduim blockers, GABA enhancers, calcuim channel blockers, glutamate blockers), surgery, vagus nerve stimulation, vitains, melatonin,ketogenic diet
Term
non-epileptic seizure
Definition
can occur with real seizures and are often dfficult to tell with are which from just watching. Generally have a more rhythmic component to movements than true seisures, can see falling, self-injury, post seizure confusion ad alterations in consciousness like real seizures. Rarely will you see tounge biting, unprotected falling, incontinence.
Term
two types of stroke
Definition
hemorrhagic and obstructive
Term
hemmorrhagic stroke
Definition
caused by bleeding within brain from rupture of blood vessel (usually from malformed blood vessel or one weakened by high blood pressure. Are most fatal type of stroke.
Term
obstructive stroke (aka ischemic stroke)
Definition
stroke caused by a plugged up blood vessel which prevents blood flow. 80% of strokes are this kind
Term
thrombus
Definition
a blood clot that forms within a blood vessel, which may occlude it causing a onstructive stroke.
Term
embolus
Definition
a piece of matter such as blood clot, fat or bacterial debris that dislodges from its site of origin and occludes an artery, can lead to stroke in its in brain
Term
cause of death of neurons when blood supply to a region of brain inturrupted by stroke
Definition
the presence of excessive amounts of glutamate
Term
TIA
Definition
"mini-stroke"-symptoms do not persist and are typically reversed in minutes to hours. Impairment last up to 15 mins and fully resolve within one day. Rates of stroke after TIA are 4-8% in 30 days and 24-29% in 5 years
Term
deficits caused by stroke
Definition
depends of size and site of stroke. Motor deficits, incontinence, visual changes, auditory changes, loss of sensatio, cognitive deficits common no matter what location
Term
prevention and treatment for strokes
Definition
prevention by meds or changes in diet and exercise, clot busting drugs (one good drug called tPA), blood thinners,carotoid endarterectomy (removing plaque in artery), or putting a stent in a clogged artery
treatment with physical therapy or speech therapy,
Term
Parkinson's Disease
Definition
caused by degeneration of the nigrostriatal system which secrete dopamine. Symptoms are muscular rigidity, slowness of movement, resting tremor and postural instability. 1% of people over 65, most cases sporadic, meaning theu occur in people without a familiy hisotry of parkinsons. May be triggered by exposure to enviromental toxins, by a faulty metabolism or by unrecognized infectious disorder. There are some forms of Parkinsons that are heridity though, caused by genetic mutation, although most arnt.
Term
treatment of Parkinsons
Definition
Dopamine therapy-givin L-Dopa, the precursor of dopamine. This only works temporarily until there is too little dopomineric neurons. Other treatments include fetal tissue transplant of healty subsantia nigra, pallidotomy (lesioning an area of globus plaalidus), or deep brain stimulation
Term
Huntingtons Disease
Definition
Degeneration of the caudate and the putamen of basil ganglia, particually GABA and Ach neurons. Symptoms are uncontrollage, jerky limb movements that sometimes seem to contain parts of meaningful movements. Earlier onset than Parkinsons. Is hereditary. Eventually causes death 10-15 years after symptoms begin.
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