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neurologic disorders pt 2
linton
62
Pharmacology
Undergraduate 1
06/27/2023

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Term
pts with migraine headache may experience _ before the onset of pain
Definition
irritability, vision disturbances, nausea, parethesia
Term
medications such as _ may help to control the vascular influences of migraine headache
Definition
beta-blockers, calcium channel blockers
Term
to treat chronic migrianes in adults _ is used for those individuals with migraine headaches greater than 14 days of the month that last more than _ a day
Definition
onabotulinumtoxin A (botox), 4 hours
Term
botox injections to treat migrain are given every _ weeks to prevent migraine headaches before they start
Definition
12
Term
the patient with a concussion may have loss of consciousness lasting less than 5 minutes and may have a
Definition
headache, amnesia bout the event, nausea and vomiting
Term
usually the result of tearing of the veins that drain the brain, allowing blood to accumulate in the space beneath the dura
Definition
subdural hematomoa
Term
three types of subdural hematomas
Definition
acute, subacute, chronic
Term
forms in the space between the inner suface of the skul and the outermost meningeal covering of the brain which is knonw as the dura
Definition
epidural hematoma
Term
in general, epidural hematomas result from _ secondary to a laceration and tearing of the middle _
Definition
laceration, meningeal artery
Term
organisms may reach the meninges through the blood via
Definition
head wounds or from other cranial structurs such as the sinuses or inner ear
Term
instruct the patient to avoid couging and not to hold his or her breath during turning because these behaviors increase
Definition
ICP
Term
complications of encephalitis include
Definition
changes in LOC, increased ICP, cranial nerve palsies, motor and sensory changes, speech function
Term
the patient with encephalitis has symptoms directly r/t to
Definition
the area of the brain involved
Term
guillain barre syndrome is also known as
Definition
acute inflammatory polyneuropathy
Term
the greatest threat to patients with GBS
Definition
respiratory dysfunction
Term
other types of parkinsonism are caused by
Definition
atherosclerosis, long term ue of phenothiazines
Term
major triad symptoms of parkinson syndrome
Definition
termor, rigidity, bradykinesia
Term
a movment associated with tremor r/t to parkinson syndrom is
Definition
pin rolling
Term
the tremor repetitively moves the individual's thumb against the fingertips as if rolling a small object
Definition
pin rollying
Term
extremely slow movements
Definition
bradykinesia
Term
jerky movements with passive muscle stretching
Definition
cogwheel rigidity
Term
the most beneficial physical therapy programs for parkinsons disease incorporate
Definition
massage, heat, exercise, gait refraining
Term
in the early stage of parkinson disease dopamine receptor agonists _ are used to maximize the intrinsic dopamin
Definition
pramipexole (mirapex), ropinirole (requip)
Term
the cornerstone of therapy for parkinson disease is th euse of
Definition
L-dopa (l-dihydroxyphenylalanine)
Term
can conrss the blood brain barrier and is converted to dopamin in the basal ganglia, thereby supplementing levels of the neurotransmitter and rducing the symptoms of the disease
Definition
L-dopa
Term
the conversino of l-dopa to dopamine must occur in the _ and not in the peripheral tissue
Definition
basal ganglia
Term
to ensure the absorption of L-dopa when treating parkinson's disease, inhibitors are administered to prevent the breakdown of l-dopa by _
Definition
decarboxylase enzymes
Term
the decarboxylase inhibitor most commonly used is
Definition
carbidopa
Term
carbidopa is frequently given in combination as
Definition
carbidopa/levodopa(sinemet)
Term
the enzyme _ also breaks down levadopa in the peripheral circulation
Definition
catechol-omethyltransferase
Term
blocks the breakdown of levodopa and prolongs the effectiveness of carbidopa/levodopa
Definition
entacapone (comtan)
Term
a combination drug that provides maximum blocking in the peripehral ciculation and decreases the number of pills taken at one time
Definition
carbidopa/levodopa/entacapone(stalevo)
Term
because the benefits of _ tend to decline after about 2 years, various other drug combinations bay be used to control symptosm
Definition
l-dopa
Term
selegiline hydrochlorid (a moi inhibitor) is used with _ to also treat parkinson disease
Definition
senemet
Term
inc reases the available dopamin
Definition
selegilin hydrochloride
Term
anticholinergic drugs such as _ may be used in patients who have less sever symptoms or who are unresponsive to L-dopa
Definition
trihexyphenidyl(artane) and benztropine (cogentin)
Term
suggestions to improve moility with parkinson syndrome include the following
Definition
scoot to the edge of a chair before trying to stand, use satin sheets to make it easier to move in and out of bed, march in place before starting to walk, practice lifting the foot as if to step over an object on the floor to initiate walking
Term
a chronic progressive degenerative disease that attacks the protective myelin sheath around axons and isrupts the conduction of impulses through the CNS
Definition
multiple sclerosis
Term
MS progresses steadily
Definition
chronic progressive MS
Term
MS becomes stable with no active disease for at least 1 year
Definition
stable MS
Term
most common symptoms of MS
Definition
fatigue, weakness, tingling in one ro more extremities, visual disturbances, problems with coordination, bowel and bladder dysfunction, spasticity and depression
Term
for patients who have excerbating remitting MS the progression is
Definition
variable
Term
because of its chronic progressive nature, the treamtent of MS is
Definition
symptomatic and supportive
Term
drug therapy during periods of execerbation of MS may in o involve administration of
Definition
adrenocorticotropic hormones
Term
may be used to control exacerbations of MS but do not slow the progression of the disease
Definition
corticosteroids
Term
an immune moduclator that is unrelated to interferon used to treate MS
Definition
glatiramer (copaxone)
Term
Immunosuppresssant dugs such as _ are also used for exacerbations
Definition
mitoxantrone(novantrone) and natalizumab(tysabri)
Term
used for acute exacerbation and relapses of MS
Definition
glucocorticosteroids
Term
the spasticity nexperienced by MS patient may respond to treamtent with
Definition
baclofen(lioresal) or tizanindine(zanaflex)
Term
used to relieved neuropathic pain r/t MS
Definition
carbamazepine (tegretol) and gabapentin (neurontin)
Term
used to relieve fatigue associate with MS
Definition
amantadine (symmetrel)
Term
urinary retention r/t MS is treated with cholinergic drugs such as
Definition
bethanechol (urecholin) or neostigmine (prostigmine)
Term
urinary frequency and urgency resulting from spasticity of the bladder r/t MS cna be treated with anticholinergics such as
Definition
propantheline bromide (pro-banthine) or oxybutynin(ditropan)
Term
a comppetititve muscarinic receptro antagonists and si more specific for the bladder than oxybutynin, used to treat MS
Definition
tolterodine (detrol)
Term
useful for urinary issues r/t to failure to stroe and empty urine r/t MS
Definition
tamsulosin (flomax)
Term
eveidence of upper motor neuron disease includes r/t myeasthenia gravis
Definition
spasticity and hyperrreflexia
Term
lower motor neuron diseas produces R/T myasthenia gravis
Definition
weakness, atrophy, cramps and muscle twitching
Term
musles responsible for fine movements such as _ are often affected early in MYASTHENIA GRAVIS
Definition
eye, facial, hand muscles
Term
anticholinersterase drugs that increase the availabiltiy of acetylcholin at the neuromuscular junction, for myasthenia gravis
Definition
neostigmine and pyridostigmine (mestinon)
Term
the patient taking pyridostigmine must be monitored for overdose which is characterized by
Definition
GI discomfort, diarrhea, nausea and vomiting
Term
adverse effects of pyridostigmine
Definition
increased bronchial and oral secretions (dangerous for pt with dyspagia and resp involuntary involvement) cramping and muscle fasciculation
Term
cytotoxic therapies for pt unable to taper corticosteroid drugs
Definition
azathioprine and cyclosporine
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