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Neurobiology
Exam 3
50
Biology
Undergraduate 2
03/23/2009

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Term
interaural intensity (level) difference
Definition
mechanism for sound localization sensitive to high frequency sounds
Term
superior olivary nucleus
Definition
the point at which signals from the two ears converge.

located in brainstem, behind cochlear nucleus
Term
feedback mechanism in sensory system that affects how well physical signal can reach receptor neuron
Definition
tightening of muscles on ossicles
Term
cornea
Definition
has highest refractive power (focusing ability)
Term
mAchR neurotransmitter receptor
Definition
involved in inhibitory feedback onto outer hair cells
Term
ventral pathway
Definition
in extrastriate cortex

involved in encoding objects (form vision)
Term
PDE
Definition
effector enzyme

causes cGMP levels to drop in response to a flash of light in rods
Term
cortical magnification
Definition
the fovea, a small region of the retina, has a large representation in cortex compared to the peripheral retina
Term
ions that flow into retinal cells to cause depolarization
Definition
Na and Ca flow into rods/cones
Term
ions that flow into cochlea cells to cause depolarization
Definition
K flows into hair cells
Term
how extrastriate cortex is casually-related to the perception of motion
Definition
microstimulation of columns of direction-selective neurons that preferred a given direction and the perception for motion was biased in the direction of the stimulated column
Term
divergence for retinal cells
Definition
foveal cones diverge to 2 midget cells

cones in many regions of retina synapse onto multiple bipolar cell types

bipolar cells synapse onto many amacrine/ganglion cell
Term
divergence in cochlea cells
Definition
inner hair cells make synapses onto multiple spiral ganglion cells
Term
guanylyl cyclase activating proteins (GCAPS)
Definition
part of a calcium dependent feedback mechanism (they are inhibited by bound Ca and become active when Ca drops during the flash response) that stimulates guanylyl cyclase to cause generation of cGMP, re-opening cation channels and reversing the light response
Term
hyperpolarization
Definition
present dark stimulus to cell's receptive field surround
Term
depolarization
Definition
present light stimulus to cell's receptive field surround
Term
stages of processing in hyperpolarization of cone's receptive field surround
Definition
cones in surround are depolarized by dark stimulus

increased glutamate release

excitation of horizontal cells

increased feedback inhibition onto recorded cone

hyperpolarization of recorded cone
Term
g-protein cascade
Definition
closes cation channels
Term
ON bipolar cell
Definition
metabotropic glutamate receptor

glutamtate closes cation channel and hyperpolarizes cells via G protein cascade

reverses sign of cone
Term
OFF bipolar cell
Definition
ionotropic glutamate receptors

glutamate opens cation channel and depolarizes cell

preserves sign of cone
Term
interaural time difference
Definition
mechanism for sound localization sensitive to low frequency sounds

the intensities are different in each ear due to different length delay lines between left and right nuclei that project to the olivary cell
Term
complex cell
Definition
in primary visual cortex (V1, striate cortex)

regions excited by dark and light overlap
Term
simple cell
Definition
cell in primary visual cortex (V1, striate cortex)

regions excited by dark and light sit side-by-side
Term
4C layer
Definition
do not receive input from both eyes
Term
retinotopy
Definition
nearby regions of cortex should have receptive fields that code nearby regions of space
Term
blob regions
Definition
color-opponent receptive fields
Term
outer hair cell
Definition
receives direct inhibitory feedback from the brain stem
Term
superior colliculus
Definition
brain region that contains a complete point-to-point representation of auditory space
Term
AMPA glutamate receptor
Definition
responsible for membrane depolarization that causes Mg2+ to leave another channel
Term
cation that enters cell to induce postsynaptic LTP
Definition
Ca2+
Term
spectral shape clue
Definition
mechanism for sound localization does not work well with pure tones
Term
Layer IV of primary visual cortex
Definition
ocular dominance columns (cell stimulated by one eye but not the other)
Term
left hemifield
Definition
recording from right hemisphere
Term
layer 2/3 blob region
Definition
are stained by cytochrome oxidase
Term
most numerous receptor in human retina
Definition
rod
Term
highest sensitivity to dim light
Definition
rod
Term
receptor represented by more than one cell type, each with different spectral sensitivities
Definition
cone
Term
11-cis-retinal molecule
Definition
light-sensing molecule
Term
first step of amplification in rod phototransduction cascade
Definition
R* activates hundreds of transducins (G*)
Term
melanopsin
Definition
largest dendritic field diameter

excitation causes hyperpolarization

intrinsic photo-sensitivity (can block rods and cones)

are involved in circadian rhythms
Term
normal ganglion cells
Definition
parasol, midget
Term
rodamine staining
Definition
LGN and pretectum stained with rodamine, then injected with HRP antibodies. it gets to ganglion by axons from the optic nerve.

stains all ganglion cells (red)

antibodies bind selectively to giant cell ganglions (green)

giant ganglion cells projecting to LGN (yellow)
Term
analogy between 2-point discrimination in somatosensory system and acuity in visual system
Definition
hand is like fovea--small receptive field and high acuity

back is like retinal periphery--large receptive field and low acuity
Term
Calcium-Dependent feedback mechanisms that shut off rod light response
Definition
1. CNG channels become more sensitive (require less cGMP to open)

2. R* phosphorylated and quenched by arrestin

3. guanylyl cyclase produces more cGMP, opening the CNG channels
Term
blob region of V1
Definition
double-opponent cells
Term
surround mechanism
Definition
inhibitory feedback from horizontal cells to cones
Term
OFF bipolar center-surround receptive field
Definition
surround HYPER

center DEP
Term
ON bipolar center-surround receptive field
Definition
surround DEP

center HYPER
Term
inner plexiform layer
Definition
bipolar cells terminate here
Term
ionotropic glutamate receptor AMPA
Definition
ON and OFF ganglion cells
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