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Neuro
rxtydyk
58
Biology
Undergraduate 3
02/27/2011

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Term
major inhibitory neurotransmitters
Definition
gaba and glycine
Term
acetylcholine precursors and enzyme
Definition
acetyl CoA and choline catalyzed by choline acetyltransferase
Term
decreases acetylcholine concentration in synaptic cleft
Definition
acetylcholinesterase
Term
acetylcholinesterase turns acetylcholine into...
Definition
acetate and choline
Term
ionotropic acetylcholine receptor
Definition
nicotinic ach receptor
Term
metabotropic ACh receptor
Definition
muscarinic ACh receptor
Term
precursor of glutamate
Definition
glutamine
Term
three types of ionotropic glutamate receptors
Definition
NMDA AMPA and kainate
Term
glutamine to glutamate enzyme
Definition
glutaminase
Term
glutamate to glutamine enzyme
Definition
glutamine synthetase
Term
transporter that removers glutamate from synaptic cleft
Definition
EAAT
Term
glutamate packaging transporter
Definition
VGLUT
Term
Glutamate cycle
Definition
Glutamine -Glutiminase- Glutamate -VGLUT-synapse-EAAT- Glutamate -Glutamine Synthetase- Glutamine -EAAT-
Term
GABA cycle
Definition
Glutamate -Glutaminic acid decarboxylase- GABA - reuptake by GAT
Term
Glycine cycle
Definition
Serine -serine transhydroxymethylase- glycine - VIATT packaging transporter
Term
ion associated with ionotropic gaba receptors
Definition
Cl-
Term
ion associated with metabatropic gaba receptors
Definition
K+ or Ca2+
Term
ion that glycine inhibition is because of..
Definition
Cl-
Term
3 catecholamines
Definition
dopamine, norepinephrine, epinephrine
Term
2 non catecholines
Definition
histamine, seratonin
Term
biosynthetic pathway for all catecholamines
Definition
tirosine (tyrosine hydroxylase) - DOPA (DOPA decarboxylase) - Dopamine (dopamine hydroxylase) - norepinephrine (phenylathanolamine n methyl transerase) epinephrine
Term
dopamine found mostly at this place in the brain, source?
Definition
substantia nigra
Term
norepinephrine found mostly at this place in the brain
Definition
locus coeruleus
Term
epinephrine found mostly at this place in the brain
Definition
medulla
Term
histamine found mostly at this place in the brain
Definition
hypothalamus
Term
serotonin found mostly at this place in the brain
Definition
raphe nuclei
Term
# of subunits in ionotropic receptor
Definition
4-5
Term
# of subunits in metabotropic receptor
Definition
7
Term
glutamate needs cofactor _____
Definition
glycine
Term
facilitation is build up of what?
Definition
Ca in presynapse
Term
depression is caused by prolly...
Definition
depletion of pool of synaptic vesicles
Term
augmentation is caused by
Definition
short term, helping Ca bind vesicles and release neurotransmitters
Term
potentiation is caused by
Definition
long term, helping Ca bind vesicles and release more NT
Term
sesitization in sea slug does what on a neuron level?
Definition
recruits additional neurons,modulatory interneurons release serotonin onto presynaptic sensory neurons which enhances NT release
Term
reduces probability that K channels open - longer action potential - more Ca to release more NT
Definition
PKA (protein kinase A)
Term
NT responsible for sensitization
Definition
serotonin
Term
long term sensitization, causes PKA to be persistently active
Definition
CREB
Term
In the hippocampus, the enhancement of a weakly activated group of synapses when a nearby group is strongly activated.
Definition
associativity
Term
A persistent strengthening of synapses based on recent patterns of activity
Definition
long-term potentiation (LTP)
Term
An enhancement of synaptic transmission resulting from high-frequency trains of action potentials.
Definition
post-tetanic potentiation (PTP)
Term
Increased sensitivity to stimuli in an area surrounding an injury. Also, a generalized aversive response to an otherwise benign stimulus when it is paired with a noxious stimulus.
Definition
sensitization
Term
Timing-dependent activity, probably the result of Ca2+ signaling in the postsynaptic cell, that is required for the establishment of some forms of synaptic plasticity.
Definition
spike timing-dependent plasticity (STDP)
Term
A short-term decrease in synaptic strength resulting from the depletion of synaptic vesicles at active synapses.
Definition
synaptic depression
Term
bind synaptic vesicles to components of the cytoskeleton which prevents them from migrating to the presynaptic membrane and releasing transmitter
Definition
synapsin
Term
how do vesicles get released from synapsin? what process and what agent?
Definition
phosphorylation by CaMKII
Term
involved in priming, regulate assembly of SNAREs
Definition
NSF and SNAPS
Term
SNARE protein in synaptic vesicle membrane
Definition
synaptobrevin
Term
SNARE proteins in plasma membrane
Definition
syntaxin and SNAP-25
Term
Ca binds to it and it catalyzes membrane fusion
Definition
synaptotagmin
Term
protein that helps curve the budding membrane
Definition
clathrin
Term
protein that pinches of membrane at the completion of budding
Definition
dynamin
Term
3 proteins that uncoat the vesicle of clathrin
Definition
auxilin Hsc-70 and synaptojanin
Term
action potential starts at this point
Definition
axon hillock
Term
make myelin in CNS
Definition
oligodendrocytes
Term
make myelin in PNS
Definition
Schwann cells
Term
damage control non-neuron cells
Definition
microglial cells
Term
neurons that carry info away from brain
Definition
efferent neurons
Term
neurons that carry info to the brain
Definition
afferent neurons
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