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Neuro #3
Clin Med diseases
221
Medical
Graduate
05/23/2010

Additional Medical Flashcards

 


 

Cards

Term
Seizure
Definition
o A transient disturbance of cerebral function caused by an abnormal neuronal discharge
o SAH, EtOH Withdrawal
Term
Epilepsy
Definition
group of disorders characterized by recurrent seizures
Term
Aura
Definition
partial seizure experienced as a peculiar sensation preceding the onset of a generalized seizures or complex partial seizure that my take the form of a gustatory, visual or auditory experience; a feeling of dizziness or numbness; or just “a funny feeling”
Term
Prodrome
Definition
o Early clinical manifestations, such as malaise, headache, or sense of depression, that may occur hours to a few days before the onset of a seizure
Term
Tonic phase
Definition
state of muscle contraction in which there is excessive muscle tone
Term
Clonic phase
Definition
state of alternating contraction and relaxation of muscles
Rhythmic movement that occurs
Term
VITAMEN
Vascular, Idiopathic, Trauma, Autoimmune, Metabolic, Endocrine, Nature
Definition
What causes seizures
Term
• Benign febrile convulsions of childhood
• Idiopathic epilepsy
• Head trauma
• Stroke/vascular malformations
• Mass lesions
• Meningitis or encephalitis
• HIV encephalopathy
Definition
List primary neurologic disorders
Term
• Idiopathic-- young ppl
• Febrile--children…not accustomed to fevers
• Metabolic--biphasic (children and elderly)
• Infection/Trauma-- younger(more exposed)
• Stroke/tumor--Later in life
Definition
When do seizures occur?
Term
Generalized Seizures
o Tonic-clonic (grand-mal) – rigid, shake
o Absence (petit mal) – just staring into space, no motor manifestation
o Other types (tonic, clonic, myoclonic)

Partial Seizures
o Simple partial
o Complex partial
o Partial Seizures w/ secondary generalization
Definition
Types of seizures (list)
Term
)– Fasting glucose
– Serum calcium
– Serum FTA-ABS
– Serum electrolytes
– Complete blood count
– Erythrocyte sedimentation rate (screening)
– Renal function studies
– Hepatic function studies
Definition
Seizure: Ancillary evaluation Blood studies (list
Term
positive in 20–59% of first EEG
Positive in 59–92% with repeated EEGs
Definition
EEG % positive for seizures...
Term
Benign Febrile Convulsions
Definition
2-4% of children ranging in age from 3 mo. to 5 y.o.
Usually will occur during the first day of a febrile illness
Last for less than 15 mins
Lack focal features (not just arm…tend to be generalized)
Over 60% experience a single seizure (might repeat 1 time)
Fewer than 0.1% than three seizures
Differential Diagnosis includes meningitis or encephalitis
Term
convulsionsgenerally self limiting
Diazepam 0.3mg/kg po, IM or IV prn TOC
Rule out an infectious or structural cause
CT scan (rule out mass effect), LP

Anticonvulsants not indicated unless
Persistent neurologic deficits
Recurrent seizures develop
Definition
tx for benign febrile
Term
Idiopathic epilepsy
Definition
more than 75% of all seizure disorders
No specific structural or other cause can be established for seizures
Usually begins between the ages of 5 and 25 years and more than 75% of these patients have their first seizure before 18 years old
Term
recurrent seizures
Definition
Recurrence rates range from about 30-70% in different published reports
Higher (more likely) in patients w/:
•Electroencephalographic abnormalities such as a generalized spike-and-wave pattern
•Postictal Todd Paralysis or persistent neurologic abnormalities
•Focal weakness in part of the body after a seizure
•Multiple seizures prior to evalulation
•Family history of afebrile seizures
Term
Generalized Tonic-Clonic
Definition
oInitial manifestations are unconsciousness and tonic (rigidity) contractions
oUsually without aura or other warning
oIf there is a warning it usually consists of nonspecific symptoms
oContraction of masticatory muscles may cause tongue trauma
oPatient falls may cause injury
oThere is postictal confusion and often headache
oOrientation commonly takes 10-30 mins
Term
Status Epilepticus
Definition
seizures that continue for more than 30 minutes without ceasing spontaneously, or which recur so frequently that full consciousness is not restored between successive episodes
A medical emergency that may cause permanent brain damage if untreated
Seizure-- Postictal state-- Another seizure for at least 30 minutes (you do not recover from the first before the second)
Term
Absence (Petit mal) seizures
Definition
• Genetically transmitted seizures that always begin in childhood and rarely persist into adolescence
• Characterized by brief loss of consciousness (5-10 seconds) w/o loss of postural tone
• Subtle motor manifestations, such as eye blinking or a slight head turning, are common
• Full orientation immediately follows cessation of the seizures
• Characteristically inducible by hyperventilation (can do in office)
• More often picked up by teachers (lights on but not home)
Term
Tonic Seizures
Definition
• Characterized by continuing muscle contraction that causes fixation of the limbs and axial musculature in flexion or extension (board like)
• The cessation of ventilator movements leads to cyanosis
• Consciousness is lost
• No clonic phase
Term
Clonic Seizures
Definition
• Characterized by repetitive clonic jerking
• Accompanied by loss of consciousness
• No initial tonic component
Term
Myoclonic Seizures
Definition
• Sudden, brief, shock like contractions that may be localized to a few muscles or one or more extremities or that may have a more generalized distribution
• Not accompanied by loss of consciousness
Term
Simple partial Seizures
Definition
motor, sensory, or autonomic phenomena
Clonic movement in the face, a limb, or the pharynx
Jacksonian March (moves along the motor cortex…face-- arm, etc…)
Autonomic symptoms may consist of pallor, flushing, sweating, pupillary dilation, vomiting, incontinence
Psychic symptoms include dysphasia, distortions of memory
Consciousness is preserved
No postictal state; can provide info bc they were awake
Term
Complex partial Seizures
Definition
•Consciousness, responsiveness or memory is impaired
•Seizure discharge usually arises from the temporal lobe or medial frontal lobe
aura
automatism-- orobuccolingual (75%) other head/neck (50%)
Secondary generalization may occcur
Not processing info properly, but not unconscious
Term
Pseudoseizures
Definition
• Episodes that resemble seizures and may be manifestations of a psychiatric disturbance
• Usually can be distinguished by the clinical exam findings and normal EEG
• Patients will rarely harm themselves
Term
Dilantin seizure tx
Definition
o Oral lading dose of 1000 mg in 2-4 divided doses over 12-24 hrs
o Maintenance dosage of 300-400 mg/d in 1-2 doses
o Requires lab testing with a therapeutic range of 10-20 g/mL
o Indicated for Partial, Generalized, and Partial Seizures with generalization
o 20% will develop gingival hyperplasia (red, beefy, gums)  lead to decay, dental dz
Term
Carbamezapine or tegretol seizure tx
Definition
o Initial dose 100 mg bid and increase to a total dose of 400-1600 mg/d
o Requires lab testing: range of 4-12 mcg/mL
o Useful for Partial Seizures including the generalized partial seizures
o Hematologic problems that occur  aplastic anemia, agranulocytosis (OBTAIN CBC)
Term
Valproic acid or depakote seizure tx
Definition
o Requires no loading dose and is initiated b/w 750-3000 mg/d in 2-3 doses
o Requires lab testing with a range of 50-150 mcg/mL as therapeutic
o Useful for the full range of seizures including:
 Generalized tonic-clonic
 Myoclonic
 Absence
 Partial
 Secondary generalization
o MUST BE SURE IT’S RECURRENT, comes in sprinkly form for children
Term
• Blood pressure: exclude hypertensive encephalopathy or hypoperfusion
• Temperature: exclude hyperthermia
• Pulse: exclude life-threatening cardiac arrhythmia
• Lab studies for glucose, calcium, electrolytes, hepatic and renal function, CBC, ESR, and toxicology as well as ABG and urine for toxicology
• Insert intravenous line and administer glucose (50 mL of 50% dextrose)
• Rapid physical examination
• CT Scan to rule out mass lesion or hemorrhage (MRI?)
• Lumbar puncture, unless the cause of seizures is known
Definition
Emergent evaluation for status epilepticus
Term
Ativan or Lorazepam 0.1 mg/kg IV1 at rate not greater than 2 mg/min
•Effective half life is 14 hours (better choice

Valium or Diazepam 10 mg IV over 2 minutes
•Effective half-life is 15 minutes
•Treats the current seizure
•Abrupt respiratory depression or hypotension in 5%
•Seizures recur in 50% of patients- add anticonvulsant
•Cerebryx (Fosphenytoin) 20 mg/kg IV at <150 mg/min which results in peak serum concentration 10-20 mins
Definition
Emergent tx of status epilepticus
Term
• Repeat Cerebryx 10 mg/kg IV
• Repeat Ativan or Diazepam IV
• Propofol 1–2 mg/kg IV bolus followed by 2–4 mg/kg/h infusion and titrate infusion between 1 and 15 mg/kg/h (ANESTHESIA)
• Intubation and ventilatory support required
• Hypotension is can be a factor and vasopressors may be required- dopamine up to 10 mcg/kg/min
Definition
tx persistent seizures
Term
Injury has occurred to any of the following structures:
o Bony elements
o Soft tissues
o Neurological structures
Definition
Spinal trauma defined as...
Term
• Instability of the vertebral column
• Actual or potential neurological injury
Definition
2 concerns of spinal trauma
Term
Spinal Instability
Definition
Loss of normal relationship between anatomic structures with a resulting alteration of natural function
Term
• Fracture of vertebral body, lamina, and/or pedicles
• Dislocation of anatomic components caused by disruption of soft tissues
• Fracture and dislocation may occur together
Definition
Instability results from
Term
Axial
Definition
Traumatic forces:
• Fibers are pushed together in a crushing manner
• Tends to fracture vertebrae in multiple pieces
• Usually associated with flexion, extension, or rotational injuries
Term
Distraction
Definition
Traumatic forces:
• Bony, disc, or soft tissue elements are pulled apart
• Usually associated w/flexion or extension injuries
Term
Flexion
Definition
traumatic forces:
• Severe forward bending of the neck or trunk
• Causes compressive force on the anterior vertebral column; teardrop or wedge type fracture to v. body
Term
Extension
Definition
Traumatic forces:
• Severe backward bending of the neck or trunk
• Axial loads often also associated
• Compressive force on facet, lamina, spinous processes and distractive force on anterior aspect of cord
• Causes fractures to the spinous process and lamina
Term
Shear
Definition
Traumatic forces:
• Force parallel to the surface on which it acts; results in a translation or subluxation movement
• Usually result in anterior or lateral displacement of affected elements
• Hit from the side
Term
Rotational
Definition
Traumatic Force:
• Torsional force that creates a rotational tension on tissue fibers
• Often associated with axial forces
Term
Used to grade thoracolumbar and cervical fractures

Based on 3-column theory of the spine:
o Anterior = ALL and anterior 2/3 of vertebral body/disc
o Provides support to contain nuclear material in disk
o Middle = posterior 1/3 of vertebral body/disc and PLL (make up middle column of spine)
o Posterior = pedicles, lamina, facets, post. Ligaments
Definition
Denise Classification Method
Term
neurologic injury
Definition
trauma to spinal cord, cauda equina, nerve roots
 Can result from bone, bone fragments, or disc material compressing on neurologic structures
 All structures innervated by the affected neurologic structure may lose all or partial function
Term
only structures it innervates
Definition
o Injury to a specific nerve results in neurologic loss to
Term
permanent loss of neurologic function below the affected level
Definition
Complete cord lesion results:
Term
can show some neurologic improvement, particularly when motor function remains intact
Definition
Imcomplete cord lesion results;
Term
complete or incomplete neuro function

complete loss of function with no chance of recovery
Definition
o Injury to cauda equina may result in ___
o Injury to conus medullaris generally results in ___
Term
o A = Complete loss of motor and sensory function
o B = Only sensory function remains
o C = Motor function is present but of no practical use (i.e., can move legs but not walk)
o D = Motor function impaired (i.e. can walk but not with normal gait)
o E = No neurologic impairment noted
Definition
Frankel Score (reverse order) for Classification of Neurologic Injury
Term
Thoracolumbar Flexion compression fracture
Definition
o Frequently occur at T12, L1 levels
o Usually anterior column failure
o Usually, if middle and posterior columns are intact, fracture is considered stable
o Verterbral body in anteriro column gives way first.. If it extends further may have progression into posterior column
Term
Thoracolumbar Flexion-distraction fracture
Definition
o “Chance fractures”
o All 3 columns may fail
o Bone, ligament, and disc injuries
o Anterior subluxation
o Common seatbelt injury
Term
Burst fracture
Definition
o Violent compressive load with failure of anterior and middle columns; unstable fracture
o Loss of vertebral height
o Risk of retropulsed bone and neurologic injury
o Most common fracture with deer stand injuries
o If you get enough compression, then you get retropulsed bone
Term
Low lumbar flexion distraction fracture
Definition
o “Jumper’s fracture”
o Severe compressive load on anterior column; distractive forces on middle/posterior columns
o Associated with high degree of lower extremity fractures
o Falls are most common cause
Term
Low lumbar Compression, torsion, translation fracture
Definition
o Occur with or without flexion
o Compression effects on lateral margins of vertebral body
o Torsion/translation affects vertebral body, disc, ligamentsg
o Twisting component instead of vertebral bodies being aligned, they will be pushed off to the side.
Term
Cervical spondylosis
Definition
A degenerative condition of the cervical spine manifest by disc collapse, osteophyte formation and neural encroachment
As the population ages this is becoming more common
Usually includes one or more of the following symptoms
o pain and stiffness in the neck
o pain in the arms with or without a motor deficit
o sensory deficit in the arms
o upper motor neuron deficit in the legs
Term
Cervical spondylosis
Definition
Hand sensory complaints are initial symptoms
o Particularly fine movements
o Most often have a long history of neck discomfort
o Unusual to see incontinence
o Good proximal strength but very poor dexterity in hands
o Atrophy of small muscles– slow progression .
Term
Cervical Spondylosis
Definition
o Weakness with atrophy of small muscles
o Spasticity
o Hyper active reflexes (clonus)
o Lhermitte sign
o Gait disturbances
o Manifestations of upper motor neuron w/fine motor deficits in their hands
Term
Lhermitte sign
Definition
o Is the momentary paresthesia (shocklike or tingling sensation) that shoots down the trunk or limbs during active or passive flexion of the neck.
o Can also occur with cough or straining
o Like Tenil sign for median nerve
Term
Cauda Equina Syndrome
Definition
Injury to nerves w/I the spinal cord as they exit the lumbar and sacral regions:
• Usually fractures below L2
• Can also occur w tumors
• Specific dysfunction depends on level of injury
Term
Cauda Equina Syndrome
Definition
• Flaccid-type paralysis of lower body
• Bladder and bowel impairment
• Won’t have reflex changes, or spinal cord injury patterns bc it is a lower motor neuron process. (can’t have clonus)
Term
Motor
o Strength/Tone
o Reflexes
o Spasticity
Sensation
o Pain and Position
o Think in terms of all different tracts
Rectal Tone
o Bulbocavernousus Reflex
Definition
Cauda Equina Syndrome Exam...
Term
STERIODS:
Solumedrol Protocol
o 30 mg/kg IV initially over 15 minutes
o 5.4 mg/kg IV for 23 hours

This must be started within 3 hours of SCI
Definition
Cauda Equina Syndrome tx
Term
Neurogenic shock
Definition
High thoracic or low cervical injury with loss of SNS
Eliminates the “fight” or “flight” response
Get all Parasympathetic response
o Vasodilation below injury level
o Pooling of Blood (at risk for blood clot)
o Decreased venous return to heart
o Decreased cardiac output
Term
Autonomic Dysreflexia
Definition
• Lesion @ or above T6
• Usually occur after acute phase of SCI or spinal shock
• Noxious stimuli is trigger
• Can come about from UTI, impaction, infection, cellulitis
Term
Autonomic dysreflexia
Definition
• Sympathetic response (tachycardia, sweating)
• Severe elevated BP
• Flushed head/neck, cool lower ext
• Pallor
• Headache
• Bradycardia
• Pupil dilation
Term
+address immediate problem with BP control, then go looking for cause .
+Relieve Trigger
Definition
Autonomic dysreflexia tx
Term
Aneurysmal Bone Cysts
Definition
• Not “true” tumors; evaluated and treated as such
• Patients are teens or 20s
• Occur most frequently in posterior elements
• Slight predominance in Females

tx
• Embolization and surgical resection
Term
Giant cell tumor
Definition
• Very aggressive
• Primarily in sacrum
• Women> men
• Age 30-40
• May be associated with bladder/bowel dysfunction

tx
• Wide en-bloc (all in one) resection; adjunctive radiation therapy
Term
Hemangioma
Definition
• Most asymptomatic; found on incidental exam
• Symptomatic lesions seen in pts 30-40 yrs
• Vertebral body affected
• Frequentlly seen in thoracic spine
• Risk of pathologic compression:
o Fracture
o Hematoma
o Expanding tissue mass
o Neurologic compromise

tx
• Based on size, location, neurologic involvement, pt age and health
• TOC-- complete excision
Term
osteoid osteoma
Definition
• Common in spine
• Males 20-40 yr
• Posterior elements of lumbar spine: lamina or pedicle
• Lesion size about 2cm
• Scoliotic deformity may be present

tx
• Complete surgical resection
Term
osteoblastoma
Definition
• Similar histologically to osteoid osteoma; more aggressive but not as common
• Males 20-30 years old
• Posterior elements lumbar spine
• Lesion size <2cm
o Smaller, so may not be quite as problematic
• Potential to become malignant
o Can differentiate into sarcoma

tx
• Total resection
Term
Chordoma
Definition
• Rare, slow-growing, slow to metastasize over sacum
• Originate from cells of primitive nervous system
• 2:1 male to female ratio
• Patients 50-70 years of age
• Half of all chordomas occur in sacrococcygeal region
• Also found at base of skull near foramen

tx
• Surgical treatment usually difficult due to location; excision if possible
• Low patient survival rate
Term
osteosarcoma
Definition
• Rare, highly malignant
• Affect younger population; increased frequency in males
• Vertebral body most often affected; pedicles and posterior elements may also be involved

tx
• Treatment of choice is radical excision with chemotherapy/radiation
• Generally poor prognosis due to metastases
Term
chondrosarcoma
Definition
• Rare; arise from cartilaginous tissue
• Slow growing; patient may not present until tumor is well established
• In spine, most common in thoracic, lumbar, sacrum
• 2:1 male-to-female

tx
• Surgical treatment difficult due to location in spine; tend to be resistant to chemo and radiation
• Overall poor prognosis
Term
Round cell tumors
Definition
• Group of malignant tumors classified by histological similarity
• Also called plasma cell tumors
• Highly malignant;occur frequently in spine
• Includes
o Plasmacytoma
o Multiple Myeloma
o Lymphoma
o Ewing’s Sarcoma
Term
Plasmocytoma
Definition
• 3:1 male-to-female; >50 years of age
• Thoracic spine
• Half of patients go on to develop multiple myeloma

tx
• Treatment of choice is radiation therapy
• Surgery may be used for decompression/stabilization
Term
Multiple myoloma
Definition
• Most common bone malignancy in adults!!
• Most often found in the spine
• Male-to-female ratio is equal; most patients 50-80 years of age
• Other systemic organs may be involved; renal failure common

tx
• Surgery rare except to decompress and stabilize; treatment of choice is radiation/chemo because of multiplicity of tumors
Term
lymphoma
Definition
• Usually non-Hodgkin’s type
• Most patients 40-60 years of age
• Usually widely disseminated throughout the body
• Anterior column most frequent spinal site

• Respond to radiation and chemo; surgical decompression/stabilization may be indicated
Term
Ewing's sarcoma
Definition
• Common in children 10-15 years
• 2:1 male-to-female
• May have associated soft tissue mass
• Half of tumors occur in sacrum
• High incidence of neurologic involvement

tx
• Tri-modal treatment: surgical excision, radiation and chemo
• 5-year survival rate is <20%
Term
o Direct erosion from near-by neoplasm
o Arterial metastasis through nutrient arteries (lung tumors thought to spread through segmental arteries)
o Venous distribution through azygous system (prostate and breast cancers)
o Dissemination through lymphatic system; suspected but not clearly demonstrated
Definition
Four theorized mechanisms for metastasis
Term
Intramedullary (10%) or inside the spinal cord
o Ependymomas are the most common type (approximately 60% of cases; gliomas make up the remainder--> astrocytoma is the most common; oligodendroglioma)

Extramedullary (90%) or outside the spinal cord (May be extradural or intradural)
• Neurofibromas and meningiomas are relatively common, benign tumors which can be intra- or extradural
Definition
• Tumors can be divided into two groups
Term
Spinal cord tumors
Definition
Pain is a conspicuous feature and usually the initial abnormality for any of the tumors that we’ve reviewed
o Not relieved by rest
o Often occurs at night
o No difference in severity of pain from benign or malignant tumors
Term
o Radicular or
o Localized to the back or
o Diffusely in an extremity
o May be aggravated by coughing or straining
o May develop motor symptoms (heaviness, weakness, stiffness ) of one or more extremities
o May have paresthesias or numbness, especially in the legs
Definition
With extradural lesions the pain may be
Term
Dysethesia
Definition
o an unpleasant sensation produced by a stimulus that would usually be painless
o taking stimulus that normally wouldn’t be problematic but in this condition it will be unpleasant; is painful from otherwise normal thing
Term
Paresthesia
Definition
o abnormal spontaneous sensations, such as burning, tingling, or pins and needles
o abnormal, fall asleep on arm feeling; can be painful
Term
Numbness
Definition
o Non specific term used by patients to describe a sense of heaviness, weakness or deadness and sometimes to signify any sensory impairment
Term
Idiopathic inflammatory
metabolic & nutritional
infectious/granulomatous
vasculitic
neoplastic and paraproteinemic
drug-induced and toxic
hereditary
Entrapment
Definition
8 categories of peripheral neuropathies...
Term
Guillain-Barre' Syndrome
Definition
Acute or sub-acute polyneuropathy that can follow minor infective illnesses, vaccines or surgery
Term
Guillain barre syndrome
Definition
Presents with gradual onset of symmetric weakness
+Usually begins in the legs
+Typically an ascending weakness which is greater than the sensory loss
+Will progress over several weeks
+Can ascend to point of causing bowel/bladder dysfunction
+May have autonomic dysfunction
+May develop respiratory failure
Term
guillain barre syndrome
Definition
Lumbar puncture may reveal
Increased CSF protein after 1 week
CSF white blood cell count less than 10/mcl
Term
Usually symptomatic/ supportive
+Weakness will gradually recede after 4 weeks
+Prevent complications
 respiratory failure
 vascular collapse– lose arterial tone w/o proper innervation… causes dilation and blood pressure decreased… need something to cause vasoconstriction
+Plasmapheresis may reduce the time required for recovery and may decrease the likelihood of residual neurologic deficits
Definition
tx for guillain barre syndrome
Term
chronic inflammatory demyelinating polyneuropathy
Definition
Very similar to Guillain-Barré

Chronic progression or characterized by relapses with no improvement within the 6 months after onset
Term
Chronic inflammatory demyelinating polyneuropathy
Definition
EMG reveals a demyelinative neuropathy with superimposed axonal degeneration
Term
Often responsive to treatment with corticosteroids
+Prednisone 60–100 mg/d for 2–4 weeks then slowly tapered to 5–20 mg every other day

May have to be continued long-term
Definition
tx for chronic inflammatory demyelinating polyneuropathy
Term
Diabetic amyotrophy
Definition
due to
+radiculoplexopathy, +polyradiculopathy +polyradiculoneuropathy
Term
Diabetic dysautonomia
Definition
+postural hypotension
+disturbances of cardiac rhythm
-- doesn’t regulate BP, HR, or temperature
+impaired thermoregulatory sweating
+disturbances of bladder, bowel, gastric and sexual function
--can have diabetic gastroparesis
Term
diabetic amyotrophy
Definition
+ Damage to muscle nerves and atrophy/decrease in size b/c of innervation damage
+Pain, weakness and atrophy of pelvic girdle and thigh muscles
+absent quadriceps reflexes and little sensory loss
Term
diabetic mononeuropathy multiplex
Definition
+characterized by pain and weakness
+often has a vascular basis
+ described as nerve entrapment or acute vascular injury
Term
+Anticonvulsants
--Tricyclic antidepressants
--Elavil– old medication that can be utilized and is very effective
--Give at bed time– sedating– helping them sleep and get mood improvement
+Anti arrhythmics
+Topicals including capsaicin and lidocaine
+Surgically implanted stimulators
Definition
Medical intervention for diabetic neuropathy--
Term
entrapment neuropathies
Definition
 When a nerve is compressed, stretched, or angulated by adjacent anatomic structures to such an extent that dysfunction occurs.
 Initial clinical complaints are of sensory symptoms or pain
Term
 Carpal Tunnel
 Ulnar Tunnel– either at wrist or cubital tunnel
 Thoracic Outlet
 Tarsal Tunnel
Definition
more common entrapment neuropathy syndromes...
Term
carpal tunnel syndrome
Definition
Commonly seen with
+Cumulative trauma
+Pregnancy

Trauma/fracture dislocation/pregnancy fluid retention/injury edema– all can lead to compression in the canal, raising pressure
Term
+Tinel’s sign
--Tapping on the median n. at the wrist
--if positive then reproduce symptoms in median distribution (1/2 of ring, long, index, and palmar side of thumb; dorsal side to first joint)
+Phalen’s sign
--Pressing the backs of hands together with the wrist flexed
+Nerve conduction velocity testing
Definition
testing for carpal tunnel syndrome includes
Term
Ulnar neuropathy
Definition
Compression at the elbow worsened by repetitive use
+“Cubital tunnel”
+Can be seen at the wrist in Guyon’s tunnel but more likely to occur over medial olecranon (funny bone)
Term
Tinel’s sign at elbow and NCS

Test abductor pollicis brevis on thumb… shouldn’t be able to push thumb in…

Put pinky and thumb together– shouldn’t be able to pull finger through the connection
Definition
test for ulnar neuropathy
Term
Radial neuropathy
Definition
"Saturday Night Palsy”

Compression of the radial nerve in the axilla by pressure from crutches or sleeping on the arm
Term
Radial neuropathy
Definition
Weakness in wrist extensors with associated sensory loss
+Dorsum of hand to first joint is nerve distribution
+Wrist drop and sensory loss
Term
Neurologic or Vascular
+Cervical rib seen in about 1% of the population
+Hypertrophy in scalene muscle or presence of 1st bony rib
Definition
causes of thoracic outlet syndrome
Term
thoracic outlet syndrome
Definition
Pain and paresthesia in the C8-T1 distribution

Doesn’t give aboslute weakness b/c of multiple innervations in brachial plexus
Term
“hand’s up” test
+‘Hands up’ position with elbows braced firmly backwards, chin elevated: Hands clenched and opened for 3 min
+Positive test:
pain, heaviness or profound arm weakness or numbness and tingling of the hand

Allen Test
+The examiner flexes the patient’s elbow to 90° while the shoulder is extended horizontally and rotated laterally
+The patient turns his head to the opposite side
+Keep palpating the radial pulse
+Positive Test
Radial pulse disappearance-Decrease in pulse decrease in blood flow from radial artery
Definition
test for thoracic outlet syndrome
Term
peroneal nerve palsy
tarsal tunnel syndrome
femoral neuropathy
lateral femoral cutaneous
Definition
list lower extremity neuropathies...
Term
peroneal nerve palsy
Definition
trauma or pressure at the head of the fibula
dorsiflexion weakness of the foot (looks like L5 root)
Term
Tarsal tunnel syndrome
Definition
Located at the ankle immediately below and behind the medial malleolus
Burning pain in the foot usually at night

Not really associated with weakness as no major motor function comes from tarsal tunnel
Term
femoral neuropathy
Definition
Rare but can be seen with diabetes and retroperitoneal problems
symptoms and signs relate to weakness of the quadriceps muscle with absent or decreased reflex
Term
lateral femoral cutaneous
Definition
“meralgia paresthetica”
Sensory changes in the anterolateral aspect of the thigh
Pregnant women and fat guys with big belts! “burning in pockets”
Term
lyme disease
Definition
associated with inflammatory mono- or polyradiculopathy, brachial plexopathy, mononeuropathy (including facial palsy), and mononeuropathy multiplex
Term
bell palsy
Definition
Facial weakness of the lower motor neuron type

Idiopathic although there is some suggestion that HSV 1 may be implicated in some cases.

More common in pregnant women and diabetics

Complete and incomplete types based on the degree of motor weakness
Term
bell palsy
Definition
+Taste change
+Lacrimation
+Hyperacusis (increased hearing)
+Eye drooping
Term
Most patients recover completely w/o tx
+May take several days or several months
+Poor prognosis for complete recovery present initially with severe pain and complete palsy
Definition
bell palsy prognosis...
Term
Treatment with corticosteroids
+Must be started within 5 days after the onset of palsy
+Prednisone 60 mg/d orally for 3 days, tapering over the next 7 days
Definition
bell palsy tx
Term
myasthenia gravis
Definition
Muscular weakness which is the result of a variable block of neuromuscular transmission related to an immune-mediated decrease in acetylcholine receptors

Occurs at any age

More common in females than males
Term
myasthenia gravis
Definition
Most commonly involves
+External ocular muscles
+Certain other cranial muscles:
--masticatory, facial, pharyngeal, and laryngeal muscles.
+Respiratory and limb muscles
Term
myasthenia gravis
Definition
+fluctuating weakness
+easy fatigability of voluntary muscles

Muscle activity cannot be maintained and initially powerful movements weaken readily

Not progressive!!
Term
Confirmed by the benefit that anticholinesterase drugs have on the power of affected muscles

Tensilon (edrophonium) test:
+Cholinergic agonist
+10mg/ml given as 2 mg IV and then 8 mg after 30 seconds
+Strength will be dramatically improved for about 5 mins
+Watch for cholinergic crisis
--Treat with Atropine

CT scan of the chest r/o thymoma

Serum acetylcholine receptor antibody levels often elevated
Definition
dx/test for myasthenia gravis
Term
Mestinon (Pyridostigmine )
+Anticholinesterase inhibitor
+Helpful in maintaining overall strength
+ 60 mg qid
Definition
tx for myasthenia gravis
Term
myasthenic syndrome
Definition
• Lambert-Eaton Syndrome
• Usually seen in conjunction with neoplasm or pernicious anemia
• Tumor antibodies react with Ach release
• Extraocular muscles are spared and strength will increase if contraction is maintained

• Muscle get stronger as you hold the strength rather than fatiguing

works on pre-synaptic region
Term
motor neuron disease
Definition
Group of disorders characterized by weakness and muscular wasting without sensory change
Term
+Usually occur in the first year of life
+Fairly uncommon
SMA1, SMA2 and SMA3
Definition
infantile motor neuron disease...
Term
Usually occurs between 30-60 yrs old
men more than women
Definition
Adult motor neuron disease...
Term
bulbar involvement
Definition
Difficulty in swallowing, chewing, coughing, breathing and talking
Term
progressive bulbar palsy
pseudobulbar
progressive spinal muscular atrophy
primary lateral sclerosis
amyotrophic lateral sclerosis
Definition
Adults have 5 varieties of motor neuron disease distinguished by their clinical presentations
Term
progressive bulbar palsy
Definition
Motor nuclei of cranial nerves
Drooping of the palate; a depressed gag reflex; pooling of saliva in the pharynx; a weak cough; and a wasted, fasiculating tongue
Term
pseudobulbar
Definition
Bilateral corticobulbar involvement

the tongue is contracted and spastic and cannot be moved rapidly from side to side
Term
progressive spinal muscular atrophy
Definition
Primarily lower motor neuron
Term
primary lateral sclerosis
Definition
Pure upper motor neuron in limbs
Term
amyotrophic lateral sclerosis
"lou gehrig's disease"
Definition
Mixed UMN and LMN deficits are found in the limbs
May be bulbar involvement

Dx made clinically when
+Definite Upper and Lower motor neuron signs in the bulbar and two spinal regions or in three spinal regions

Tx is generally supportive

Riluzole 100 mg daily may reduce mortality/slow progression

fatal 3-5 years
Term
causalgia
Definition
Results from nerve trauma
+improper IM injection or placement of an arterial catheter at the wrist

Onset of pain may be at any time within the first 6 weeks after nerve injury

+Severe persistent pain, often burning in quality
+ Radiates to a more extensive territory

exquisite tenderness
Term
reflex sympathetic dystrophy

"complex regional pain syndrome"
Definition
more general term that denotes sympathetically mediated pain syndromes precipitated by a wide variety of tissue injuries

following soft tissue injury or fractures

+extremity sweating
+temperature
+color changes

sympathetic blockade with anesthetics

surgical sympathectomy

Great success has been seen with spinal stimulation
Term
radiculopathy
Definition
Radicular pain is localized to the distribution of one or more nerve roots

+Motor weakness in the appropriate myotome
+Reflex change
+Sensory change in the appropriate dermatome
Term
back pain
Definition
Causes of are numerous!
+Muscular
--sprain and strain
+Skeletal
--Fracture
--Osteoarthritic
Term
spinal stenosis
Definition
Arises from facet and intervertebral age-related changes that reduce the patient’s quality of life

Degenerative process that results in narrowing of overall diameter of spinal canal

Neurogenic claudication
Term
neurogenic claudication
Definition
Inability to walk or stand for any length & progressively worsens
Term
• Disc Bulge/Herniation
• Hypertrophied Ligamentum flavum
• Narrowed Spinal Canal
• Narrowed Lateral Recesses
• Hypertrophied Facets
Definition
lumbosacral spine disease characteristics
Term
Non REM/ Slow sleep
Definition
• Represent about 75% of total sleep time
• Starts with the withdrawal of NT from the RAS and inhibits the arousal mechanisms from the cortex
• Pulse, BP, breathing, and BMR are all decreased
Term
o Stage I – light sleep w/ alpha waves and slow eye movement
o Stage II – Further slowing of EEG
o Stage III – Low frequency Delta Waves
o Stage IV – Delta Wave
Definition
stages of slow sleep...
Term
REM
Definition
 Represents about 25% of total sleep time
 Occurs about every 90 minutes (cycle)
 Associated with increased pulse and B/P as well as altered breathing
Term
REM
Definition
 There is atonia of muscles which can lead to respiratory obstruction involving the tongue and upper pharynx
Term
Insomnia
o Trouble falling asleep…total sleep time is disturbed
Primary Sleep Disorders
o Sleep Apnea
o Restless Leg Syndrome
Hypersomnia
o Narcolepsy
Definition
classes of sleep disorders
Term
insomnia
Definition
“Difficulty in initiating or maintaining sleep”

More common in males
-May be transient or long-term
-Assoc. w/ daytime sleepiness and fatigue
-Problems initiating sleep are more common w/ psych issues
-Problems maintaining sleep are more likely medical
Term
Education is the cornerstone of initial treatment:
-Caffeine avoidance after lunch
-No alcohol prior to bed time
-Sleep hygiene
-Room prep
-The three S’s  schedule, sex, sleep…bed used solely for these things
Definition
insomnia tx cornerstone...
Term
Multiple classes of medications available
-OTC products
>>Benadryl
>>Melatonin
-Benzodiazepines (dangerous in elderly)
>>Restoril (tomazepam)
>>Clonazepam (Klonopin)
-Non-benzodiazepines
>>Ambien
>>Sonata
-Antidepressants
>>Elavil
>>Trazodone
Definition
insomnia tx medications
Term
restless leg syndrome
Definition
-May be assoc. w/ PLMS
>>Periodic Limb Movement Syndrome
>>Rhythmic movement of the extremities every 20-40 sec that interrupt normal sleep
>>Common entity that occurs in 50% >65 y.o.

-Motor & Sensory changes may be related to spinal dz or other problems such as anemias
Term
Underlying disease may be the first treatment
Alternate agents may include
Benzodiazepine
-- clonazepam or Klonopin
GABAergic
--Baclofen or Lioresal (muscle relaxant, titrate dosage to effect)
--Gabapentin or Neurontin (also for HA, neuralgia)
Dopaminergic
--Ropinirole or Requip
--Pramipexole or Mirapex 2 mg at bedtime
Definition
tx for restless leg syndrome
Term
sleep apnea
Definition
Breath cessation for at least 10 seconds

Central – from brainstem…not obstructive process!
Term
hypopnea
Definition
decrease in airflow w/ drop in hemoglobin saturation of at least 4%
Term
central apnea
Definition
absent ventilator effort during the episode which is very uncommon
Term
obstructive apnea
Definition
ventilator effort during the episode but no airflow occurs because of transient obstruction of the upper airway
Term
mixed apnea
Definition
occurs if absent ventilator effort precedes upper airway obstruction during the episode
Term
sleep apnea
Definition
Patient may report:
 daytime somnolence
 morning sluggishness
 headaches
 daytime fatigue
 cognitive impairment
 recent weight gain
 impotence
Term
sleep apnea
Definition
Bed Partner may report:
 loud cyclical snoring
 breath cessation or apnea
 Restlessness or thrashing in bed
 Personality changes
Term
may appear sleepy and a "bull neck" appearance is common
Oropharynx may be narrowed by
--excessive soft tissue folds
--large tonsils
--pendulous uvula– predisposed by an anatomic structure
--prominent tongue
Nasal obstruction
--deviated nasal septum
--poor nasal airflow
Note if there is a “nasal twang” to the speech
Definition
physical exam for sleep apnea reveals
Term
weight loss
CPAP
BIPAP
uvulopalatopharyngoplasty
nasal septoplasty
radiofrequency reduction of tissue
tracheotomy
Definition
sleep apnea tx
Term
narcolepsy
Definition
Sudden, brief (about 15 minutes) sleep attacks that may occur during any type of activity
Term
narcolepsy
Definition
Cataplexy – sudden loss of muscle tone
Sleep paralysis
hallucinations

starts early adult life, levels off around 30 y.o.
Term
narcolepsy
Definition
On PSM, these attacks are characterized by an abrupt transition into REM sleep – a necessary criterion for diagnosis (GOLD STANDARD)
Term
Dextroamphetamine or Dexedrine

Modafinil or Provigil – helps w/ orientation to time zones
Definition
tx for narcolepsy
Term
• Electroencephalography
• Electro-oculography
• Electromyography
• Electrocardiography
• Pulse Oximetry
• Measurement of Respiratory effort/airlow
Definition
A true sleep study would include
Term
movement disorders
Definition
A disorder which impairs the regulation of voluntary motor activity without directly affecting strength, sensation or cerebellar function
Term
movement disorders
Definition
 Sometimes AKA “extrapyramidal disorders”
 Can be hyperkinetic or hypokinetic
 Most are a dysfunction of the basal ganglia
 Strength is fine…movement is not
Term
 Myoclonus
 Ballismus
 Chorea
 Athetosis
 Dystonia
 Tics
 Tremors
Definition
types of abnormal movement
Term
myoclonus
Definition
-Sudden, brief, shock-like involuntary movements
>>Positive myoclonus – caused by active muscle contraction
>>Negative myoclonus – caused by inhibition of ongoing muscle activity (eg. Asterixis) relaxation causes movement

-Generalized  widespread throughout body
-Focal/Segmental  restricted to particular part of body
Term
generalized myoclonus
Definition
-Physiologic
>>Nocturnal (usually on falling asleep)
>>Hiccups (steroids induce hiccups that can last days)
-Essential which occurs in the absence of other abnormalities
>>Benign and sometimes inherited
-Epileptic from a demonstrable cortical source
-Symptomatic secondary to a disease process
>>Neurodegenerative (eg. Wilson’s Dz)
>>Infectious (eg. CJD, Viral encephalitis)
>>Toxic (eg. PCN, antidepressants)
>>Metabolic – anoxic brain damage, hypoglycemia, hepatic failure (asterixis) or renal failure
Term
segmented/focal myoclonus
Definition
-Can arise from lesions anywhere in the CNS and originates from many of the processes that can cause generalized myoclonus
-Example is “palatal myoclonus” audible clicking sound or synchronus movements of ocular or facial muscles
-This type is not altered by sleep or stress
-Depends on where they originate…may see on PSN…won’t change if awake vs. sleeping
Term
Valproic acid or Depakote is the drug of choice
Anticonvulsants
May respond to benzodiazepines such as clonazepam or Klonopin
Also may benefit from
5-hydroxytryptophan which is the metabolic precursor of the neurotransmitter serotonin
-- This is available as an herbal supplement which Griffonia simplicifolia
Definition
tx for myoclonus
Term
ballismus
Definition
-volent “flinging” movement of entire limb
>>More volatile b/c of larger groups of muscles
-Involves proximal musculature sometimes thought of as a “proximal unilateral chorea”
-Usually due to a CVA in contralateral subthalmic nucleus
Term
chorea
Definition
-Consist of rapid irregular muscle jerks that occur involuntarily and unpredictably in different parts of the body
In florid cases the often forceful involuntary movements of the limbs and head and the accompanying facial grimacing and tongue movements are unmistakable
-Strength is generally intact but they may be able to maintain muscular contraction
>>Classic example is the “milkmaid grip”
>>Creates difficulties w/ gait, swallowing, and speech
>>The jerking disappears w/ sleep (Ballismus and some myoclonus do not)
Term
athetosis

"changeable"
Definition
-Slow flowing, often twisting movements
-Occurs mainly distally in the hands or fingers but can affect face and tongue
>>Very find motor/small muscle type of movement
-Sometimes see it referred to as choreoathetosis due to overlap between this and chorea
>>Continuation of movement that co-exists
Term
dystonia
Definition
condition in which there is a sustained abnormal posture or limb position
Term
dystonia
Definition
-Blepharospasm: involuntary foreceful closure of eyes
-Toritcollis: tendency of neck to twist to one side
-Writer’s cramp: posturing of arm when hands used to perform specific task (e.g.) writing , playing piano
Term
tics
Definition
Classified as: Transient simple, chronic simple, persistent simple or multiple
Term
tics
Definition
-May be suppressed voluntarily or with distraction
-Not usually present during sleep
-Voluntary suppression over time leads to significant anxiety
-Worse under stress/movement
-Tourette’s
Term
tremors
Definition
Rhythmic oscillatory movement which can be resting, postural, or intention
Term
benign essential tremors
Definition
>>AKA Familial Tremor--Autosomal Dominant:
>>One or both hands (not anywhere else…at least not often)
>>Can involve head & voice (fluctuation b/c it involves muscles in articulation
>>Legs tend to be spared
>>Neuro exam is otherwise without normality
>>May worsen w/ age, but does not progress to a disability
Term
-Propanolol (Inderal)-- Beta Blocker
>>Often used for stage fright @ very low doses (10mg)
-Primodone (Mysoline)-- Anticonvulsant
-Alprazolam (Xanax)-- Benzodiazapine
>>Habituating and probably not a great long-term med
Definition
tremor tx
Term
The normal balance between the two antagonistic neurotransmitters dopamine and acetylcholine is disturbed in the basal ganglia
Definition
What casues Parkinson’s?
Term
Parkinsonism Tremor

Rigidity

Hypokinesia

Abnormal Gait and Posture
Definition
clinical findings of parkinsonism
Term
++Clinical dx but there are numerous other conditions w/overlapping symptoms
++MRI scanning to rule out tumor, NPH, stroke
++Lab testing to include heavy metals, thyroid disease, urinary copper
Definition
dx for parkinsonism
Term
Early medication choices may include blocking the acetylcholine
Benztropine (Cogentin)
Trihexyphenidyl (Artane)
Definition
early medications for parkinsonism
Term
Later medication choices will involve increasing the dopamine
Amantadine (Symmetrel)
Levodopa (Sinemet)
Definition
later medications for parkinsonism
Term
Thalamotomy or pallidotomy
Definition
surgery for parkinsonism
Term
parkinsonism tremor
Definition
++Characteristically a resting tremor
++Increases with emotional stress
++Improves during voluntary activity
++It commonly begins in the hand or foot
rhythmic flexion-extension of the fingers termed a “pill rolling” tremor
rhythmic pronation-supination of the forearm
++It frequently involves the face in the area of the mouth or tongue
Term
parkinsonism rigidity
Definition
described as “cogwheeling” because of ratchet-like interruptions of passive movement that may be due to the presence of tremor
Term
hypokinesia
Definition
++Slowing of voluntary movements and a reduction in automatic movement, such as swinging the arms while walking
++“Masklike facies ”
--Widened palpebral fissures
--Infrequent blinking (poverty of movement)
--Fixed facial expression and a smile that develops and fades slowly
--Voice is of low volume
++Handwriting is small (micrographia)
++Poverty of motion
Term
parkinsonism
Definition
++Gait consists of small, shuffling steps and absence of the arm swing that normally accompanies locomotion
++Unsteadiness on turning
++May have difficulty stopping
Term
huntington's chorea
Definition
Hereditary disorder which manifests as the gradual onset of both
Dementia
Chorea
One or the other is first onset… don’t appear at same time

Paternal descent with a 50% rate of transmission
Genetic counseling very important

Most commonly seen in 30 to 50 y.o.

Occurs in all ethnic groups
Term
huntington's chorea
Definition
Normal Dopamine and normal Acetylcholine

Concentrations of GABA are decreased in the basal ganglia of these patients
Term
huntington's chorea
Definition
Dementia may initially consist of
Irritability
Moodiness
Antisocial behavior

Chorea– won’t always start off as classical chorea-form movement
Fidgeting
Restlessness
Term
Radiographic imaging  r/o mass lesions may demonstrate atrophy of the caudate nucleus

Genetic testing will confirm

Differential would include
Benign hereditary chorea: has no dementia
Tardive dyskinesia: often related to medication
Definition
huntington's chorea dx
Term
No cure is available and is fatal over 10 t0 15years

Medications may include
++Dopamine blockers
Haldol
Chlorpromazine
++Dopamine depleting
Reserpine
++Most important tx: would be patient education given the high rate of transmission
Genetic counseling!!
Definition
huntington's chorea tx
Term
drug induced tardive dyskinesia
Definition
Syndrome of involuntary stereotyped movements of the face, mouth, tongue, trunk or limbs

Medication induced

Occurs after months or years of neuroleptic treatment in 20–35% of patients

Predisposing factors
Older age
Cigarette smoking
Diabetes mellitus
Term
Difficulty sticking out tongue or fine tongue movements
Facial tics
Increased blink frequency
Jaw movements look like tics
Definition
early signs of tardive dyskinesia
Term
Lip smacking
Chewing motions
Disturbed gag reflex
Puffing of the cheeks
Respiratory distress
Disturbed speech
Choreoathetoid movements
Definition
late signs of tardive dyskinesia
Term
Range antipsychotics to gastric motility drugs:
++Phenothiazine class drugs such as
--Thorazine or thioridazine
++Metoclopramide or Reglan
++Pimozide or Orap
++Amoxapine or Ascendin
++Risperidone or Risperdal
Definition
drug induced tardive dyskinesia tx
Term
neuroleptic malignant syndrome
Definition
Life-threatening neurological disorder
often caused by an adverse reaction to neuroleptic or antipsychotic medication (halidol commonly associated and reason for its rare usage)

Associated with anesthetic agents
Term
neuroleptic malignant syndrome
Definition
It generally presents with
Muscle rigidity
Fever (very high, 105-107 w/malignant hyperthermia)
Autonomic instability
Cognitive changes such as delirium
Term
Diagnosis is proven with a raised creatine phosphokinase(CPK)
Definition
dx neuroleptic malignant syndrome
Term
Generally supportive including cessation of the implicated medication

Start on Dantrolene– only medication available to tx malignant hyperthermia
1-2.5 mg/kg IV
Definition
neuroleptic malignant syndrome tx
Term
cerebral palsy
Definition
++Non specific term describes a static impairment of muscle strength, coordination or movements
++Non progressive
++Seen in about 0.2% of surviving infants
Term
cerebral palsy
Definition
**static!** not a progressive or deteriorating process

Approximately 75% of cases involve spasticity of the limbs;
Monoplegia
Hemiplegia
Paraplegia
Quadraplegia

The second most common form is ataxia (15%)

Other forms: involuntary movement and hypotonia
Term
cerebral palsy
Definition
Quite variable and include
+Spasticity
+Hyperreflexia
+Ataxia
+Involuntary movement
+Microcephaly is common
Term
cerebral palsy
Definition
Hemiplegia frequently have smaller and shortened limbs
Develop limb atrophy b/c of weakness and muscular development doesn’t occur… shrunken appendages
Tone could create a lot of contortion
Term
Blindness and/or Deafness commonly coexist
Seizure disorders occur in about 50%
Severe mental retardation in about 27%
Milder mental retardation in about 26%
Definition
associated neuro deficits of cerebral palsy
Term
+Muscular relaxants
+Braces– allow/guide movement and prevent from developing contractures
+Injection procedures–
botox: neuromuscular blockade to help extend/reduce contracture and resteblsih ROM
Surgery: stretching process… can go in surgically and lengthen Achilles
Definition
cerebral palsy tx
Term
All tracts disrupted
Cord mediated functions below transection are permanently lost
-No sacral sparing (this is a TRUE SC injury)
Determined ~ 24 hours post injury
Possible results
-Quadriplegia
-Paraplegia
Definition
complete spinal cord injury...
Term
Some tracts and cord mediated functions remain intact
Potential for recovery of function
Possible syndromes
-Brown-Sequard Syndrome
-Anterior Cord Syndrome
-Central Cord Syndrome
-Posterior Cord Syndrome
Definition
incomplete spinal cord injury
Term
paraplegia
Definition
loss of motor and/or sensory function in thoracic, lumbar or sacral segments of Spinal Cord
 Some arm function is spared
Term
quadreplegia
Definition
loss of motor and/or sensory function in the cervical segments of Spinal Cord
(***You are still considered a Quadraplegic if you have a CERVICAL injury but also have some function of the arms…it has to do w/ the location of the injury)
Term
anterior spinal artery syndrome
Definition
Supplies the anterior 2/3 of the spinal cord to the upper thoracic region
Caused by bony fragments or pressure on spinal arteries
Complete motor paralysis (arms > legs)
Sensory anesthesia and sparing of posterior function
Proprioception (position sense) and vibration are preserved
Term
posterior cord syndrome
Definition
Loss of proprioception, vibration and deep pressure sensations
No motor loss
RARE !
Term
central cord syndrome
Definition
Most common incomplete cord injury seen frequently in the elderly following a hyperextension injury
Arms >>> Legs
(PROFOUND upper extremity weakness w/ NORMAL lower strength)
Term
SCIWORA
Spinal Cord Injury Without Radiographic Abnormality
Definition
Seen most often in children/infants
CHILDREN ARE HYPERFLEXIBLE AND CAN GET A TRUE SC INJURY BY JUST STRETCHING THE CORD AND NOT BREAKING THE BONE
Term
Brown Sequard
Definition
Incomplete Cord Injury
Injury to one side of the cord (Hemisection)
Often due to penetrating injury or vertebral dislocation
Complete damage to all spinal tracts on affected side
Good prognosis for recovery
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