Term
| Describe the structural characteristics of the rabies virus |
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Definition
Bullet shaped (+)ssRNA
Enveloped with G protein
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Term
| What are the factors that infleunce the incubation time of rabies virus? |
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Definition
Innoculum
Amount of tissue involved
Distance from Inoculum
Host Immunity |
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Term
| What is the pathogenesis of the rabies virus |
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Definition
Bite
Retrograde to CNS(Gray Matter Replication
Autonomic Transport to Salivary and other organs |
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Term
| Does rabies require a viremia |
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Definition
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Term
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Definition
Prodrome: Fever, Nausea, Pain at Site
Neurological: Mouth Foam, CNS Symptoms
Coma: Hypotension, Cardiac Arrest
Death |
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Term
| What is the pathomneumonic lesion of rabies |
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Definition
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Term
| What type of vaccine is the rabies vaccine and what are the circumstances of its use? |
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Definition
High Risk People: 3 Vaccine injections
Vaccinated with exposure: 2 vaccine injections
Unvaccinated with exposure: 5 vaccine injections, Hyperimmune serum injected in opposing arm to the 1st injection only |
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Term
| What are the general characteristics of Arenaviruses |
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Definition
Helical (-)ssRNA
Enveloped with Z Protein
Segmented genome(S and L) with ambisense regions |
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Term
| What is the pathogenesis of Arenaviruses |
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Definition
Persistant infection: insufficient glycoprotein transcription
Macs activate T-cells, Cytokines damage to tissue and vasculature |
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Term
| What is the epidemiology and transmission of the arenaviruses |
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Definition
S. America, Africa
Transmission: Aerosolized from rodent reservoir |
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Term
| What are the kinds of arena viruses and the diseases they cause? |
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Definition
Hemorrhagic Fever: Lassa, Junin, Machupo viruses(check this fact)
Choriomenigitis: Lymphocytic Choriomeningitis virus |
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Term
What are the Filoviruses,
What are their reserviors,
What diseases do they cause,
Are they Dangerous?
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Definition
Marburg, Ebola Viruses (-ssRNA)
Reservoir:Africa-Bats/Monkeys/Humans
Disease: Hemorrhagic fever
Yes, require safety procedures during isolation |
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Term
| What is the structure of hantavirus and how is it transmitted |
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Definition
Enveloped Segmented (-)ssRNA
Transmission: Aerosol from rodents |
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Term
| What are the severe manifestations of Hantavirus infection |
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Definition
Hemorrhagic Fever w/ renal syndrome
Hantapulmonary Syndrome (Sin Nombre Virus): Pulm edema and sometimes fatal |
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Term
| What are the reservoirs of Arboviruses and how are they transmitted |
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Definition
Transmission: Mosquitos
Reservoirs: Birds
La Crosse Virus: Chipmunks/Squirrels |
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Term
| What are the families of Arbovirus |
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Definition
Togavirus
Flavirus
Bunyavirus |
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Term
| What are examples of Togaviruss |
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Definition
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Term
| What is the pathogenesis and diseases of Flaviviridae? and what do they all have in common |
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Definition
Attack Monocytes and Macrophages
Disease: Dengue, Encephalitis, Yellow Fever
Anti-body to one flavivirus provides neutralizing to all flaviviruses |
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Term
| What are the factors to maintain an arbovirus |
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Definition
Vertebrate host with long viremia
Vector able to replicate virus
Hibernation to last the winters |
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Term
| What is the pathogenesis of Arbovirus |
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Definition
Mononuclear Infilitrates
Neuronal Degen, Neuronophagia
Protein Synthesis Monopoly |
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Term
| What factors contribute to the outcome of an arbovirus infection? |
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Definition
Tropism
Concentration
Individual Response |
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Term
| What is the primary immune response to toga and Flaviviruses |
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Definition
| dsRNA induces massive IFN alpha and Beta production |
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Term
| What is the only virus screened for in blood donors and what disease does it cause |
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Definition
West nile virus
Meningitis and Encephalitis |
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Term
| What is the natural reservoir for the degue virus |
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Definition
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Term
What is the pathogenesis of Dengue Hemorrhagic/Shock Syndrome
What family viruses does the causative virus belong to? |
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Definition
Primary dengue infection with increased Anti-bodies
Secondary dengue infection with different antigenic type
Anti-body facilitates enhanced infectivity and a cytokine storm w/o neutralization
Cytokine storm causes shock and hemorrhage
Family: Flaviviruses |
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Term
| What is the family of Arbovirus that is released by the cell via lysis |
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Definition
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Term
| What is the reservoir in urban areas |
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Definition
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