Term
| What is the definition of Aseptic Meningitis |
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Definition
| Inflamation of the meninges with lymphocytic pleocytosis in CSF but no microorganisms are present |
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Term
| What are the major causes of aseptic meningitis |
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Definition
Polio
Coxsachieviruses
Echo Viruses
Leptospira interrogans
Naegleria fowleri |
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Term
| Describe the structure, virulence characteristics, transmission and reservior of the enteroviruses |
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Definition
Structure:(+)ssRNA, Naked Viruses
Virulence: Acid Resistant, Cytolytic
Transmission: Oral-Fecal Spread
Reservior: Humans Only |
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Term
| Describe the pathogenesis of enterovirus infection |
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Definition
URT or GI spread to lympahtics
Lymphatic replication-> Viremia
Systemically localized replication-> Viremia
Lysis and Inflammation induce damage |
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Term
| Describe the different manifestations of disease with the polio virus |
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Definition
Abortive Poliomyelitis: systemic sign for 3 days
Non-paralytic Poliomyelitis: systemic signs followed by backpain and muscle spasms
Paralytic Poliomyelitis: Systemic followed by Flaccid paralysis, and non-afflicted muscle spasms
Bulbar Poliomyelitis: Paralysis extends to respiratory muscles and vocal chords
Progressive Postpoliomyelitis Muscle Atrophy |
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Term
| Which Polio Vaccine is Safer, Less Expensive, produces IgA immunity, produces Herd Immunity, Co-infection doesn't interfere? |
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Definition
Safer: Injected
Less Expensive: Oral
IgA Immunity: Oral
Herd Immuity: Oral
Co-infection Ok: Injected |
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Term
| What are the indications for the oral vaccine for polio? |
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Definition
| Global Eradication in locations where Wild-type Polio is still circulating |
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Term
| What are the manifestations of Coxsachie A virus |
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Definition
Herpangina
Vesicular Rash on Hands, feet, and mouth
Aseptic Meningitis |
|
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Term
| What are the manifestations of Coxsachie B virus |
|
Definition
URT
Pleurodynia
Myo/Pericarditis
Aseptic Meningitis |
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Term
| What are the manifestations of Echo Viruses |
|
Definition
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Term
| What are the physical characteristic of Leptospira interrogans and where does it replicate in humans |
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Definition
Motile
Colied Spirochete with hooked ends
Obligate Aerobe
Replication: Endothelium |
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Term
| What are the clinical manifestations of infection with leptospira interrogans? |
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Definition
1st phase: Systemic signs
2nd phase: Myalgia, Headache, Red Eye
Severe Infection(Weil's Disease): DIC/Shock, Renal and Hepatic failure
Aseptic Meningitis |
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Term
What is Naegleria fowleri?
What is its reservoir?
How does it cause disease?
What is the Prognosis? |
|
Definition
Amoeba
Long Standing Fresh Water
Migration up the olfactery nerve causing meningoencephalitis
Prognosis: Everyone Dies |
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Term
| Can you isolate polio virus from a patient with Progressive Postpoliomyelitis Muscle Atrophy |
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Definition
| Nope, the pathology is not due to active polio virus |
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Term
| What areas of the brain are affected by polio |
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Definition
Reticualr Formation
Vestibular Nuclei
Deep Cerebellar |
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Term
| What polio virus strand causes most of the disease and which strand is not able to made into vaccine |
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Definition
Most Disease: 1
Not vaccinable: 3 |
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Term
| What is the epidemiology and transmission of leptospirosis |
|
Definition
Hawaii
Contaminated water from animal urine |
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