• Muscarinic Agonist
• Resistant to AchE, no nicotinic R activity,
• Use: GI: incr contractile force in smooth muscle (M3), Incr smooth m. contraction in bladder
• Tox: don't use with an obstruction bc rupture can occur

• Muscarinic agonist, PNS--contracts ciliary m-->accomodation for near objects, relax suspensory ligs-->convex lens, drain aq. humor, decr intraocular P.
• res to AchE, lim nicotinic R activity,
• Use: Xerostomia--facilitates lacrimal and salivary secretions. Narrow angle glaucoma.  Reverses mydriasis from atropine
• Tox: in athsma incr bronchial constriction/secretion.  Incr acid secretion in peptic ulcer, abd cramps, can't focus on far objects, salivation, sweating.

• Muscarinic agonist
• res to AchE, great activity at Muscarinic R, increases nicotinic R activity
• Toxicity: blurred vision, dry mouth, constipation, indigestion, Abd pain

Atropine

• Muscarinic antagonist--get anti PNS effects
• plant alkaloid, blocks PNS-like stuff, so blocks Ach action on muscarinic
• Use: Irrit. bowel syndrome-reduces GI tone and motility, mydriasis, retina exam
• Tox: mydriasis-->cyclopegia since vision is locked at distance and can't focus close

• Muscarinic antagonist, deriv of atropine
• Use: motion sickness prophylactically
• Tox: dry mouth, amnesia

• Muscarinic antagonist--deriv of atropine
• has M1 selectivity
• Use: peptic ulcers, preferred over Atropine bc of selectivity

• Muscarinic antagonist--derived from atropine
• Use: COPD, athsma caused by cigarette smoke
• Tox: dry mouth with inhalation

• Nicotinic antagonist (ganglionic blocking)
• Use: limited, chronic hypertension, CV regulation

• Non depolarizing drug, competitive nicotinic antagonist (NMJ), competes with Ach for binding at nicotinc R, motor weakness giving way to flaccid paralysis(sm rapid muscles first)
• Use: immobilize/paralyze wild animals, long duration of action, relaxation of skel m to facilitate operative manipulations (esp abdom)

Succinylcholine

Depolarization blocker(NMJ)--init opens Ach channels, but bc res to ACh, it lasts longer in clerft-->long depolarization.  Brief repetitive excitation--transient m fasciculations, block NMJ transmission, flaccid paralysis.

Use: office procedures bc reversed quickly, intubation, brochoscopy, esophagoscopy