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Details

Neuro Anticonvulsants
Neuroscience Block Anticonvulsant drugs
4
Medical
Professional
03/18/2008

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Cards

Term
Phenytoin
Definition
  • MOA: Use dependent inhib of volt sensitive Na and/or Ca channels
  • USE: Partial seizures(simple/complex), general tonic-clonic
  • PHAM: high degree plasma prot binding
  • TOX: GI, N, V, sedation, cognitive slowing, dizziness, ataxia, diplopia, agrunulocytosis, aplastic anemia, thrombocytopenia
Term
Carbamazapine
Definition
  • MOA: Use dependent inhib of volt sensitive Na and or Ca channels
  • USE: Partial seizures(simple/complex), general tonic-clonic, Li non responders for MDD and bipolar, trigeminal neuralgia,
  • PHARM: Variable abs, high degree plasma prot binding
  • TOX: Autonomic--GI, NV, sedation, cognitive slowing, ataxia, diplopia, agranulocytosis, aplastic anemia.  Contraind in Cardiac Ds
Term
Valproate
Definition
  • MOA: inhib GABA transaminase, inhib Na, and/or Ca channels
  • USE: Partial Seizures(complex and simple), general tonic-clonic, absense seizures, Bipolar and MDD Li nonresponders, Migraine, myoclonus
  • TOX: GI, NV, Sedation, cognitive slowing, dizziness, ataxia, aplastic anemia, agranulocytosis, thrombocytopenial; FAS, spina bifida
Term
Ethosuximide
Definition
  • MOA: inhib T type Ca Channels
  • USE: Absense seizures.  Not for kids
  • TOX: If give to someone with other types of seizures can make them worse.  GI, NV, sedation, cognitive slowing, ataxia, agranulocytosis, aplastic anemia, thrombocytopenia
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