Term
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Definition
- MOA: Depress RAS; SC dorsal horn neurons->sedation in frontal cortex->hypnosis on thal->SC motor neurons
- USE: most common inhalational
- TOX: no organ tox, safe for heart ds; decr peripheral res->decr bp, decr resp, decr cerebral vasc res-> incr CBF
- PHARM: low blood solubility: 1.4, 99% excreted unchanged in lungs
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Term
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Definition
- MOA: Blocks NMDA R (great analgesic)
- USE: anesthetic in dentistry, analgesic, adjuvant to other anesthetics->allows decr in need for halogenated anesthetics->decr side effects
- TOX: bronchodilation,decr mucociliary fx, decr metabolic rate, incr CBF, decr renal, liver BF, decr uterine contractions
- PHARM: blood solubility 0.4 (fastest induction), fastest elim, 99% excreted unchanged in lungs
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Term
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Definition
- Barbiturate, "truth drug", IV
- MOA: lipophilic, rapidly enters & depresses CNS(<1min)
- USE: induction of anesthesia(prevents excitement), NOT analgesic, good for pt with cerebral swelling
- TOX: decr cerebral metab, CBF, CO, BP, resp depression
- PHARM: short acting, diffuses fr brain to tissues
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Term
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Definition
- Benzodiazepene, IV
- USE: anxiolytic prior to anesthesia(15-60 min), sedation for non general anesthesia procedures
- PHARM: water soluble, rapid onset and shorter duration than other benzos
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Term
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Definition
- MOA: Inhib presynaptic Ca->inhib release of pain nt
- USE: induction and maintenace of IV anesthesia, epidural anesthesia (w/local anesthetics)
- TOX: potent resp depression, chest wall rigidity, impaired ventilation, decr HR and bp
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Term
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Definition
- MOA: potentiates GABAa R
- USE: Anesthesia Induction & Maintenance, day surgery(v. little vomiting), poor analgesic
- TOX: bact contamination(formulated as an emulsion), resp depression, decr cardiac contractility, periph res, ICP
- PHARM: onset as rapid as barbs but more rapid recovery
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Term
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Definition
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Term
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Definition
- Long acting ester
- MOA: Block volt gated Na channels from i/s when channel open, high firing freq fibers blocked first, decr a.p.->nerve conduction fails
- USE: opthalmology, derm, plastics, ENT, nerve block, Bier block, epidural
- TOX: restlessness, tremor, at high dose-convulsions, resp depression
- PHARM: hydrolyzed by plasma esterases
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Term
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Definition
- Medium duration amide, (see Esters)
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Term
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Definition
- Long acting Amide anesthetic--See ester actions
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