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Neural Mechanisms
CD 503 - Exam 3
48
Biology
Undergraduate 4
12/20/2012

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Term
What have we learned from aphasia pts?
Definition

1. words appear to be stored according to features like frequency and imagibility

2. comprehension has bilateral respresentation in the brain

3. language processing is automatic and voluntary

4. modalities are connected 

Term
4 main functions of the limbic system
Definition
1. homeostasis - hypothalamus
2. olfaction - olfactory cortex
3. memory - hippocampal formation
4. emotion - amygdala
HOME
Term
4 main componenets of the limbic system
Definition
1. limbic cortex [hypothalamus]
2. hippocampal formation
3. amygdala
4. olfactory cortex
HOLA
Term
Peripheral transmission of olfactory information
Definition
receptor ->nerve ->bulb ->tract
Term
Central transmission of olfactory information
Definition
piriform cortex [primary cortex] -> secondary cortex
** NO THALAMIC RELAY
Term
Working memory
Definition
mental workspace for computation [executive functions]
limited capacity
gateway to/from declarative memory
Term
Declarative memory [explicit memory]
Definition
conscious recollection of facts or experiences
stored by semantic association
Term
Types of declarative memory
Definition
1. lexical = words and their meanings
2. semantic = facts
3. episodic = events [associated with time/"time stamp"]
Term
Procedural memory [implicit memory]
Definition
non-conscious learning of skills/habits/acquired behavior
sotred by surface feature association
Term
Types of procedural memory
Definition
1. procedural = learning through repetition
2. emotional = emotion[s]
Term
Retrieval of declarative memory
Definition
frontal cortex
Term
Learning declarative memory
Definition
hippocampal structures
Term
Storage of declarative memory
Definition
cortex
Term
Storage of procedural information
Definition
UNKNOWN
Term
Brain region critical for working memory
Definition
pre-frontal cortex
Term
3 functions of the amygdala
Definition
1. orientation and attention to stimuli and allocation of processing resources to those stimuli
2. emotional responses to stimuli
3. participation in all four limbic functions through connections to tother structures in limbic network
Term
mental status exam
Definition
alertness
orientation
memory
language
calculation
apraxia
neglect
sequencing task
logic and abstraction
delusions/hallucinations
mood

an old man learned communication [although not sign language] during may
Term
functional localization
Definition
different regions of the brain are specialized for different functions
Term
2 characteristics of cortex that underlie functional localization
Definition
1. columnar organization
2. layered organization
Term
hemispheric specialization
Definition
some functions associated with the right, some with the left
Term
Right hemisphere functions
Definition
"gestalt"
music
perception of emotion
attention
PROSODY/PRAGMATICS
Term
left hemisphere functions
Definition
language
calculations
sequential processing
SEMANTICS
Term
language
Definition
abstract set of symbols representing concepts
Term
Wernicke-Geschwind model of language function
[classical model]
Definition
1. Wernicke's are is responsible for language comprehension
2. once language is understood its transmitted to broca's area via the arcuate fasiculus
3. Broca's are is responsible for language production
Term
limitations of classical model
Definition
oversimplified
aphasia can be associated with lesions to subcortical structures
most people with aphasia have problems with all modalities of language
Term
language exam
Definition
spontaneous speech
repetition
naming
reading/writing
comprehension
Term
attention to one's body and extra personal space
Definition
Posterior right parietal lobe
Term
neglect
Definition
abnormality in attention to one side of the world; not due to primary sensory or motor disturbances
Term
effects of attention on information processing in the brain
Definition
faster reaction time
enhanced detection
Term
selective attention
Definition
PRE-FRONTAL CORTEX
focusing on a specific domain above others
Term
global attention
Definition
THALAMUS
concentration/general arousal
Term
sustained attention
Definition
maintain focus over a duration of time [resisting distraction]
Term
main categories of executive functions
Definition
1. order
2. restraint
3. initiative
Doroslateral = 1
orbitofrontal = 2 + 3
Term
PFC functions
Definition
control and integration of other brain functions
-> must have connections to areas that control other brain functions
Term
executive functions
Definition
cognitive functions that are responsible for goal-directed, non-routine behavior
Term
experience changes the brain at any age
Definition
plasticity = change in response to internal or external factors
-> different finger representation in M1 of braille readers blind from birth vs. those blind as adults
Term
the nature of experience influences the nature of change
Definition
an enriched environment = better learning
-> enriched environment associated with improved maze performance
Term
timing is everything
Definition
intensive behavioral therapy in the actue state post injury may not be effective and may be detrimental to recovery
Term
neurogenesis is one possible change in the CNS
Definition
hippocamus
Term
plastic change requires repetition and maintenance or they reverse
Definition
repetition is most important in maintaining changes
-> cortical maps of braille readers changed depending on whether participants had worked 6 hours or taken the day off
Term
the recovered brain is sensitive to drugs and other effects
Definition
drugs that affect damaged systems may impair performance further
Term
CT [computerized tomography]
Definition
measures density of tissues being studied
high spatial resolution
BONE FRACTURES
ACUTE TRAUMA/HEMORRHAGE
Term
MRI [magnetic resonance imaging]
Definition
absorption/emission of NMR signal from hydrogen nuclei
no radiation exposure
SOFT TISSUE DAMAGE
T1/T2
Term
PET [positron emission tomography]
Definition
shows physiology of tissue in relation to metabolism of substrates
radiation exposure - IV contrast necessary
Term
SPECT [single photon emission computerized tomography]
Definition
generate map of cerebral blood flow
radiation exposure
Term
fMRI
Definition
not used clinically
research based
"brain mapping" [metabolic function]
Term
electroencephalography
Definition
measures electrical activity along the scalp
Term
typical approach used in neurological examination
Definition
1. problem focused
2. localization of pathology is aim
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