Term
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Definition
abn in epithelial sodium channel ENaC (increased activity produces increased Na reabsorption)
hypertension
hypervolemia
metab alkalosis: hypokalemia & hypoaldosteronism (low plasma renin activity) |
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Term
| How do you treat Liddle's syndrome? |
|
Definition
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Term
|
Definition
pseudohypoaldosteronism type 2
mutation in WNK kinase 1 & 4
increased tubular Na & Cl reabs
volume expansion/HT
hyperkalemia
low renin and aldost concentration |
|
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Term
| What are the mechanisms that cause HTN in patients with CKD? |
|
Definition
sodium retention
scarring/regional ischemia->RAA activation
symp NS
secondary hyperparathyroidism
treated with EPO
impaired NO synthesis(dilation) in patients w/uremia |
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Term
| How is renovascular hypertension detected? |
|
Definition
abdnominal bruit
one kidney sign smaller than the other
definitive: arteriogram
1.5x more renin from ischemic side |
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Term
| How do you treat primary hyperaldosteronism? |
|
Definition
| large doses of spironolactone or eplerenone |
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|
Term
| How do you detect a pheochromocytoma? |
|
Definition
| plasma metanephrine 4xs normal |
|
|
Term
| How is aortic coarctation treated? |
|
Definition
children: surgery
older children: balloon dilatation
bicuspid aortic valves: endocarditis prophylaxis |
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