Term
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Definition
| Anaphylactic: when systemic, circulation shuts down |
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Term
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Definition
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Term
| Type III hypersensitivity |
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Definition
| Autoimmune: Immune complex-mediated |
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Term
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Definition
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Term
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Definition
| Autoimmune: Ab against hormone receptors |
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Term
| What are examples of Type I hypersensitivity? |
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Definition
| Pollen reactions and food allergies and PCN reactions |
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Term
| What are examples of Type II hypersensitivity? |
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Definition
| 1. Transfusion RXN 2. Mooren's ulcer (corneal/conj involvement) 3. Autoimmune hemolytic anemia (RBC's are attacked) 4. Autoimmune thyroiditis |
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Term
| What are examples of Type III hypersensitivity? |
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Definition
| In BV's, kidneys, joints; ~Reactive arthritis (ReA) - result of STD, leads to uveitis and urethritis ~Systemic lupus erythematosus (SLE) - neovascularization, episcleritis (first sign) ~Sjogrens - destruction of salivary/ lacrimal glands ~Polyarteritis nodosa |
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Term
| What are examples of Type IV hypersensitivity? |
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Definition
| 1. TB skin test RXN (Mantoux) 2. Graft rejection Other examples: Type 1 DM, MS, Crohn's, RhA |
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Term
| What are examples of Type V hypersensitivity? |
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Definition
| ~Grave's - stimulatory hypersensitivity ~Myasthenia gravis - inhibitory hypersensitivity |
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Term
| What systemic drugs cause SPK? |
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Definition
Isotretinoin (Accutane)
Topical Aminoglycosides |
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Term
| What systemic drugs can cause endothelial/Descemet's pigmentation? |
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Definition
Chlorpromazine
Thioridazine |
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Term
| What drug can cause stromal gold deposits? |
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Definition
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Term
| What drugs can cause anterior subcapsular changes? What kind of defects to they cause? |
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Definition
Chlorpromazine = stellate cataracts
Amiodarone = deposits
Miotics = vacuoles
Gold salts = gold deposits |
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Term
| What drug causes blepharoconjunctivitis, dryness, and lid edema? |
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Definition
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Term
| What drugs can cause subconj hemorrhages? |
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Definition
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Term
| What drugs can cause Steven-Johnson syndrome and lid edema? |
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Definition
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Term
| What drug can cause pigmented cysts on the conj? |
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Definition
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Term
| What drug can cause subconj hemes along with conj hyperemia? |
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Definition
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Term
| What three drugs can cause nystagmus? |
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Definition
Phenytoin
PHenobarbital
Salicylates (aspirin/NSAIDs) |
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Term
| What drug causes impaired smooth pursuits? |
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Definition
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Term
| What drugs can cause diplopia? |
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Definition
Phenelzine
Amitryptiline
Imipramine
Fluoxetine
Diazepam |
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Term
| What drugs can cause oculogyric crisis? |
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Definition
Chlorpromazine
Thioridazine
Cetirizine (anti-histamine) |
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Term
| What is an important characteristic of tamsulosin? |
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Definition
| Induces floppy iris syndrome during surgery |
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Term
| What drug can cause retrobulbar optic neuritis, B/Y color defects and snowy vision? |
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Definition
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Term
| What drugs can cause optic neuritis? |
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Definition
*Ethambutol (most important of TB drugs)
other antibiotics that may cause optic neuritis:
Chloramphenicol
Streptomycin
Sulfonamides
unlikely culprits of optic neuritis:
Isoniazid
Methotrexate |
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Term
| What drugs can cause NAION? |
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Definition
| Viagra, Sumatriptan, amiodarone |
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Term
| What drugs can cause optic neuritis, papilledema and pseudotumor cerebri? |
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Definition
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Term
| What is a possible SE of topical epinephrine? |
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Definition
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Term
| What drug can cause white/yellow crystalline deposits in the retina? |
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Definition
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Term
| What drug can cause pigmentary retinopathy? |
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Definition
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Term
| What drug can cause macular pigment changes w/ retinal hemes? |
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Definition
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Term
| What drug can cause color vision loss and nyctalopia? |
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Definition
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Term
| What drug can increase risk of CRVO/CRAO? |
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Definition
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Term
| What 3 drugs can cause pseudotumor cerebri? |
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Definition
minocycline
doxycycline
accutane |
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Term
| What 4 classes od drugs lower IOP? |
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Definition
Systemic Beta blockers
Cardiac Glycosides
EtOH
Cannabinoids |
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Term
| What 2 anti-histamines raise IOP? |
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Definition
Bropheniramine
Diphenhydramine |
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Term
| What 2 anti-depressants raise IOP? |
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Definition
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Term
| What 2 anti-psychotics raise IOP? |
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Definition
chlorpromazine
thioridazine |
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Term
| What drugs can cause bull's-eye maculopathy? What doses are the threshold for this condition? |
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Definition
Chloroquine (risk: 6.5mg/kg/day, >5 yrs, renal dysfunction)
Hydroxychloroquine (risk: 3.0mg/kg/day, >5 years, renal dysfunction) – much less risk |
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Term
| What systemic drugs can cause miosis? |
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Definition
Opiates: morphine, codeine, Heroin
Neostigmine: |
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Term
| What 5 classes of systemic drug can cause mydriasis? |
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Definition
anti-cholinergics
anti-histamine
anti-psychotics
CNS Stimulants
CNS Depressants |
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Term
| What 9 classes of systemic drug can cause decreased tear production? |
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Definition
anti-cholinergics
hormone therapies
beta-blockers
anti-histamine
"anti-pimples": accutane
anti-depressants
anti-psychotics
CNS Stimulants
Diuretics |
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