Term
| Direct decongestants (def. and 3 ex.) |
|
Definition
bind alpha adrenergic receptors
phenylephrine
oxymetazoline
tetrahydrozoline |
|
|
Term
| Indirect decongestants (def. and 1 ex.) |
|
Definition
displace NE in presynaptic nasal nerve terminals which increase alpha adrenergic stimulation
ephedrine |
|
|
Term
| Mixed decongestants (1 ex.) |
|
Definition
|
|
Term
Topical vs. Oral Decongestants
onset/duration/ADRs |
|
Definition
Topical: quick onset/short duration/rebound congestion
Oral: slow onset/long duration/CNS and heart stimulation |
|
|
Term
| Nasal Decongestants have interactions with these 4 other classes |
|
Definition
MAOIs: contraindicated
SSRIs: augment tachycardia/vasopressive effects
Antacids: decreased elimination of psuedoephedrine (its basic) [no adr with AlOH]
Tricyclic Antidepressants: increase BP and decrease decongestion action |
|
|
Term
|
Definition
pseudoephedrine 60mg
phenylephrine 10mg |
|
|
Term
Topical Decongestants (8)
which is the best/longest acting? |
|
Definition
oxymetazoline (Afrin) [longest acting]
phenylephrine
ephedrine
epinephrine
l-desoxyephedrine
propylhexadrine
xylometazoline (Otrivin)
naphazoline (Privine) |
|
|
