Term
|
Definition
(Faslodex)
Antiestrogen/SERM
Menopaussal sx, hot flashes, NV, weight gain
BB: risk of thromboembolic events |
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Term
|
Definition
(Evista)
Antiestrogen/SERM
Menopaussal sx, hot flashes, NV, weight gain
BB: risk of thromboembolic events
Used for OP in wemen at risk of breast CA |
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Term
|
Definition
(Novaldex)
Antiestrogen/SERM
Menopaussal sx, hot flashes, NV, weight gain
BB: risk of thromboembolic events
Increased risk of endometrial CA
Shorter survival with 2D6 polymorphisms 4 and 5 |
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Term
|
Definition
(Eulexin)
PO antiandrogens,
deprive prostate of testosterone
NVD, gumecomastia, hepatotoxicity, hot flashes, dec libido |
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Term
|
Definition
(Casodex)
PO antiandrogens,
deprive prostate of testosterone
NVD, gumecomastia, hepatotoxicity, hot flashes, dec libido |
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Term
|
Definition
(Arimidex)Aromatase inhibitor
Lethargy, rash meopause sx, NV
Decreased bone density and increased risk of OP |
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Term
|
Definition
(Aromasin)Aromatase inhibitor
Lethargy, rash meopause sx, NV
Decreased bone density and increased risk of OP |
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Term
|
Definition
(Femara)Aromatase inhibitor
Lethargy, rash meopause sx, NV
Decreased bone density and increased risk of OP |
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Term
|
Definition
(Zoladex)
LHR agonist, prostate CA
Uses the negative feedback loop for a chemical castration/oophorectomy
Lethargy, rash meopause sx, NV
Decreased bone density and increased risk of OP |
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Term
|
Definition
(Cytoxan) Alkylators crosslink DNA preventing replication
Bladder toxicity with high-doses
Mylosupression, NV, alopecia |
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Term
|
Definition
(Ifex) alkylator
Myelosuppression, NV, alopecia
Must give MESNA to protect against hemorrhagic cystitis and ensure adequate hydration
Neurological toxicities |
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Term
|
Definition
(Temodar) Alkylator
Neuro toxicities
Myelosuppression NV, alopecia |
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Term
|
Definition
(Avastin) Angiogenesis inhibitor MAB
Binds to VEGF
Risk of GI perforation
Stop 28 days before elective surgery |
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Term
|
Definition
(Adriamycin) Anthracyclines
Red urine
Limited by cardiac toxicity and NV
Liposomal products have hand-foot syndrome.
Max lifetime dose 400-500mg/m2
Zinecard should be used when doses exceed 300 |
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Term
|
Definition
(Ellence) Anthracycline
Cardiac toxicity, red urine, NV
max lifetime dose=900
hand-foot synxrome
etravastatiion antidote totec |
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Term
|
Definition
(Trexall) Folate Antimetabolites
Myelosuppression, hepatic/renal toxicity
Pulmonary toxicity
Hand-foot synd
Leucovorin rescue
Elimination decreased by asa, pen, probenecid, and nsaids
maintain hydration |
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Term
|
Definition
(All-trans Retinoic Acid)
Decreases cell proliferation and promotes apoptosis
Pregnancy category X |
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Term
|
Definition
(IL-2) ustimulates immune system to target cancer cells
use restricted with normal cardiac and pulmonary
only given in hospital and icu |
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Term
|
Definition
(Erbitux) Inhibits growth factor required for cell growth and decreases cell survival
Severe infusion rxns, cardiopulmonary arrest, rash associated with higher survival rates
must test for K-ras bc if have mutation will not respond |
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Term
|
Definition
(Herceptin) Binds and reverses overactive HER-2
Cardiomyopathy |
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Term
|
Definition
(Thalomid) decreases angiogenisis
pre x
enroll in STEPS |
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Term
|
Definition
(Revlimid)
Preg x, register under RevAssist
Neutropenia and throbocytopenia |
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Term
|
Definition
(Rituxan) CD-20 target on lymphocytes kills the cancer and releases cytokines
infusions must be given in hospital or clinic
Pretreat with diphen and APAP |
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Term
|
Definition
(Platinol) highly emetogenic
(Paraplatin-AQ)
Nephrotoxic
vigorous hydration |
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Term
|
Definition
(Vincasar)
Alopecia
Dose-dependent nerve damage
IV only |
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Term
|
Definition
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Term
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Definition
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Term
|
Definition
(5-FU) Leucovorin increases efficacy
DPD deficiency increases toxicity |
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Term
|
Definition
(Xeloda) prodrug of 5-FU
DPD deficiency |
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Term
|
Definition
(Gemzar)
hepatotoxicity, pulmonary toxicity, encephalopathy
pretreat with APAP flu like sx |
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Term
|
Definition
(Taxol)
Pretreat with benadryl, h2, and dex
cardiotoxic, hepatotoxic |
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Term
|
Definition
(Taxotere)
Anaphylaxis
cardio-pulmonary fluid retention |
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Term
|
Definition
(Vepesid)
Topoisomerase 2 inhibitor
nerotoxicity/neuropathy, hepatotoxic |
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Term
|
Definition
(Camptosar)
Topo 1 inhibitor
Diarrhea tx with atropine and loperamide |
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Term
|
Definition
(Tarceva) TKI
Epidermal Growth Factor Receptor TKI
Nephro and hepatotoxic |
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Term
|
Definition
(Gleevec)
No grapefruit
philidelphia cromosome positive or cKIT |
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Term
|
Definition
(Hydrea)
Inhibits ribonucleoside diphosphate reductase |
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Term
|
Definition
(Trisenox)
QT-prolongation
monitor k and mg |
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