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Name the Neuro Disease
Nervous System UTCVM Thomas
113
Veterinary Medicine
Graduate
02/02/2014

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Term
Chondrodystrophic breeds present with this between 3-6 years old
Definition
IV Disk Disease
Term
Acute onset in type I degeneration ( a matter of hours sometimes)
Definition
IV Disk Disease
Term
Chronic fibrous degeneration in Type II
Definition
IV Disk Disease
Term
Mechanism for clinical signs is usually manifested through pressure ischemia
Definition
IV Disk Disease
Term
Large breed dogs are pre disposed at over 6 years old and express type II
Definition
IV Disk Disease
Term
Thoracolumbar lesions most commonly between T12-L1
Definition
IV Disk Disease
Term
Cervical Lesions are usually between C2-C3
Definition
IV Disk Disease
Term
A daschund presents with normal front limbs but UMN deficit hind limbs
Definition
IV Disk Disease
Term
Can present with front leg lameness due to "root signature" phenomenom if lesion on cervical vertebrae
Definition
IV Disk Disease
Term
Severe neck pain with head kept low
Definition
IV Disk Disease
Term
Intervertebral foramen ( horse head) is diminished on radiograph
Definition
IV Disk Disease
Term
See calcified material in Intervertebral foramen in certain chondrodystrophic breeds
Definition
IV Disk Disease
Term
Need MRI to dx properly in large breed dogs but usually not in the smaller breeds
Definition
IV Disk Disease
Term
For non-surgical tx... don't focus on drugs! Best tx is strict cage rest
Definition
IV Disk Disease
Term
Most common surgery for thoracolumbar lesions is hemilaminectomy
Definition
IV Disk Disease
Term
Can do surgical fenestration in all vertebrae T10-L4 prophylactically in predisposed breeds
Definition
IV Disk Disease
Term
Ventral Slot is best surgical tx for cervical region lesions
Definition
IV Disk Disease
Term
Bony spurs adjacent to disk and usually incidental
Definition
Spondylosis Deformans
Term
Lateral and Ventral osteophytes that are more common in boxers
Definition
Spondylosis Deformans
Term
Not inflammatory but need to differentiate it from an inflammatory process that could be serious like discospondylitis
Definition
Spondylosis Deformans
Term
German Shepherd form of ALS
Definition
Degenerative Myelopathy
Term
Mutation in superoxide dismutase I
Definition
Degenerative Myelopathy
Term
Progressive degeneration of myelin around axons usually starting around thoracolumbar region
Definition
Degenerative Myelopathy
Term
While most common in German Sepherds, also predisposed in boxers and Pembroke welsh Corgis... ok as a side note... what do boxers NOT get??
Definition
Degenerative Myelopathy
Term
Usually starts with UMN deficits in pelvic limbs and is NOT painful
Definition
Degenerative Myelopathy
Term
Degenerative and non treatable. Moves up spinal cord until eventually respiratory paralysis ( if it gets that far)
Definition
Degenerative Myelopathy
Term
Narrowing of lumbosacral vertebral canal and compression of cauda equina
Definition
Lumbosacral Stenosis
Term
Can get secondary yellow ligament thickening or Type II disk protrusion in L7-S1
Definition
Lumbosacral Stenosis
Term
German Shepherds most predisposed but genetic link not yet discovered. May be a disease more of "working dogs"
Definition
Lumbosacral Stenosis
Term
Not compression of main spinal cord but painful and lameness of pelvic limb due to compression of root supplying sciatic nerve
Definition
Lumbosacral Stenosis
Term
Will see incontinence and tail weakness, weak FLEXOR and perineal reflexes
Definition
Lumbosacral Stenosis
Term
Radiographs are good for ruling out other differentials but not helpful in definitively diagnosing this. An exception is when the lumbosacral joint is luxated
Definition
Lumbosacral Stenosis
Term
Like IV disk type II, MRI is the best for dx
Definition
Lumbosacral Stenosis
Term
Surgery tx of choice is DORSAL laminectomy. Usually do well if get it in time. Dogs already presenting with urinary and fecal intontinence have worse prog ( sorry that may not be that specific to this dz)
Definition
Lumbosacral Stenosis
Term
"wobbler's syndrome"
Definition
Cervical Spondylomyelopathy
Term
Malformation or articulation of caudal cervical vertebrae
Definition
Cervical Spondylomyelopathy
Term
Young large breed dogs or realtively old dobermans predisposed
Definition
Cervical Spondylomyelopathy
Term
Ataxia and paresis of all four limbs in NON chondystrophic breeds- like large breeds
Definition
Cervical Spondylomyelopathy
Term
Usually caused by a stenosis or malarticulation in cervical region which results in ligament hypertrophy and/or disk protrusion
Definition
Cervical Spondylomyelopathy
Term
Dog presents with caudal cervical neck pain, tetraparesis, atrophy and weak reflexes in thoracic limb while normal reflexes in pelvic limbs. Myelogram, CT or MRI needed for definitive dx and would see stenosis, malformations causing compression, or even collapsed disk space.
Definition
Cervical Spondylomyelopathy
Term
Surgical tx for this disease of cervical region is usually dorsal laminectomy and prognosis is difficult to predict
Definition
Cervical Spondylomyelopathy
Term
Before surgery, patients should also be ruled out for the following: von Wilebrands, Cardiomyopathies, Hypothyroidism
Definition
Cervical Spondylomyelopathy
Term
Usually in brachycephalic dogs with screw tails and frequently clinically insignificant
Definition
Hemivertebrae
Term
Failure of vertebral body to form completely in in clinical cases need myelography to dx
Definition
Hemivertebrae
Term
Partial or complete fusion of two adjacent vertebrae. Usualy incidental finding
Definition
Block Vertebrae
Term
Failure of neural tube to close or formation of cleft
Definition
Spina bifida
Term
Meningocele or myelomeningoceles can result. The former just the meninges protrude and the latter the spinal cord itself protrudes through defect
Definition
Spina bifida
Term
Can be genetic but assoc with teratogenic toxins as well. May be insignificant depending on how much protrudes through defect.
Definition
Spina bifida
Term
Bulldogs and Manx cats predisposed. Assoc with deformed tail genetics. Usually in lumbosacral region with urinary/ fecal incontinence and usually very young age.
Definition
Spina bifida
Term
Manx cat presents with Bunny Hopping gait, no anal tone, incontinence, weak pelvic reflexes
Definition
Sacrocaudal Dysgenesis
Term
Malformation or agenesis or sacro-caudal vertebrae in Manx cats
Definition
Sacrocaudal Dysgenesis
Term
Results usually from some sort of pathology with the dens and associated ligaments
Definition
Atlantoaxial Subluxation
Term
AVOID NECK FLEXION in suspected patients
Definition
Atlantoaxial Subluxation
Term
Very young toy breed dog presents with neck pain and maybe tetraplegia or paresis. May progress to Horner's syndrome in severe cases
Definition
Atlantoaxial Subluxation
Term
UMN deficits in both limbs. Severe neck pain. not a disk problem
Definition
Atlantoaxial Subluxation
Term
If trying for conservative ( non surgical tx) create a very sturdy neck brace and hope for recovery. They will probably reinjure and need surgery eventually.
Definition
Atlantoaxial Subluxation
Term
Surgical options are either dorsal or ventral fixation. Where the dorsal involves threading wire to hold vertebrae in place, the ventral is more stable with screws but is the scariest surgery Thomas does with high rates of complications
Definition
Atlantoaxial Subluxation
Term
Proliferation of normal bone at epiphysis. Not a tumor and will stop growing after reach skeletal maturity
Definition
Multiple Cartilaginous Exostoses
Term
Radiography will show circular smooth proliferative bony lesions and surgery has good prognosis if animal has stopped growing
Definition
Multiple Cartilaginous Exostoses
Term
Tract extending from spinal cord to skin
Definition
Pilonidal Sinus
Term
Rhodesian Ridgebacks get these
Definition
Pilonidal Sinus
Term
Tract that can predispose to bacterial meningitis. Surgical excision of tract is treatment along with prophylactic antibiotics until closed
Definition
Pilonidal Sinus
Term
Chiari 1 malformation in skull will predispose an animal to this
Definition
Syringohydromyelia (or just syringomyelia)
Term
Development of one or more fluid filled cavities within the spinal cord +/- accumulation of the fluid in the large central canal
Definition
Syringohydromyelia (or just syringomyelia)
Term
Underdeveloped occipital bone can cause overcrowding of caudal fossa which may result in hydrocephalus and this:
Definition
Syringohydromyelia (or just syringomyelia)
Term
Commonly caused by a malformation common in Cavalier King Charles Spaniels
Definition
Syringohydromyelia (or just syringomyelia)
Term
Medical Tx can consist of Prednisone, Gapapentin and Omeprazole which help with neuro pain and dec CSF production
Definition
Syringohydromyelia (or just syringomyelia)
Term
Surgical tx focused at decompressing caudal fossa, controversy over what to place back over skull
Definition
Syringohydromyelia (or just syringomyelia)
Term
Severe exostosis usually in cervical spine caused by all liver diet in cats
Definition
Hypervitaminosis A
Term
Most common type of spinal tumors
Definition
Extradural Neoplasia
Term
These tumors usually come from vertebrae where osteosarcs most common
Definition
Extradural Neoplasia
Term
Cat vaccine tumors:
Definition
Extradural Neoplasia
Term
FeLV a big risk for this
Definition
Extradural Neoplasia
Term
A nerve sheath tumor, or meningioma, or neuroepihtelioma
Definition
Subarachnoid Neoplasia
Term
One kind will start peripheral and move up, anothe type like to start at region over kidneys
Definition
Subarachnoid Neoplasia
Term
If see lysis on a transverse process on radiographs- most likely:
Definition
Extradural Neoplasia
Term
Includes astrocytomas and occassionally even metastatic hemangiosarcoma for example... but this type of dz is rare
Definition
Intramedullary Neoplasia
Term
Very irregular looking bony mass
Definition
Extradural Neoplasia
Term
A lot times myelogram will look a lot like IV disk disease with compression from one side on cord
Definition
Extradural Neoplasia
Term
Contrast in myelogram will show a filling defect and maybe golf tee signs
Definition
Subarachnoid Neoplasia
Term
Contrast in myelogram will diverge away from cord where sometimes whle cord will bulge contrast out
Definition
Intramedullary Neoplasia
Term
common out west with grassons and commonly Actinomyces
Definition
Spondylitis
Term
Need to test for Brucella canis
Definition
Discospondylitis
Term
Localized walled off infection usually of hematgenous origin that can progress to neuro defects with formation of granulation tissue. Can be multifocal and sometimes from penetrating wounds
Definition
Discospondylitis
Term
Can almost always diagnose with radiograph. May be multiple areas where see irregular margins of vertebral end plates that crosses the joint
Definition
Discospondylitis
Term
Always want to do three diagnostic tests wth these patients: 1. Blood culture 2. Urine culture 3. Brucella test
Definition
Discospondylitis
Term
Need long term Antibiotic tx- over 8 weeks
Definition
Discospondylitis
Term
Dx with spinal tap and look degenerative or clean segmented neutrophils
Definition
Meningomyelitis
Term
Two types are bacterial or steroid responsive
Definition
Meningomyelitis
Term
Always consider this if there is nose or sinus fracture/trauma
Definition
Meningomyelitis
Term
Bacterial kind: Acute onset, very painful especially in neck or all over, can get edema and neuro deficits within a day- need to act quick
Definition
Meningomyelitis
Term
Cloudy CSF; treat with third generation cephalosporins, mannitol, maybe even anti seizure meds
Definition
Meningomyelitis
Term
Steroid responsive most common kind
Definition
Meningomyelitis
Term
Boxers and Burnese Mountain Dogs predisposed. Consider it when 6 mo old of these breeds present in with severe neck pain
Definition
Meningomyelitis
Term
Need to differentiate from bacterial because tx is high dose prednisone. Need to do a spinal tap!
Definition
Meningomyelitis
Term
Can be stable if only dorsal or only ventral compartments but not both
Definition
Traumatic Spinal Fracture/Luxation
Term
Need to immobilize the patient first
Definition
Traumatic Spinal Fracture/Luxation
Term
Medical Management can be an IV of some form of prednisolone But due to GI hemorrhage, benefits may not outweigh risks
Definition
Traumatic Spinal Fracture/Luxation
Term
Surgery is indicated if unstable damage
Definition
Traumatic Spinal Fracture/Luxation
Term
May want to mnage other things first like circulatory shock or thoracic and abdominal injuries
Definition
Traumatic Spinal Fracture/Luxation
Term
Surgical treatment techniques include: dorsal spinal plates, vertebral body plates, or plain old pins screws and bone cement
Definition
Traumatic Spinal Fracture/Luxation
Term
Causes acute ischemic necrosis of spinal cord through vessel occlusion
Definition
Fibrocartilagenous Embolism
Term
Most common in large dogs and miniature schnauzers; Ultimate etiology/mechanism poorly understood
Definition
Fibrocartilagenous Embolism
Term
Sudden onset with no identifiable pain
Definition
Fibrocartilagenous Embolism
Term
Often asymmetrical, with no pain
Definition
Fibrocartilagenous Embolism
Term
No tx but dogs with intact pain perception usually improve in two weeks
Definition
Fibrocartilagenous Embolism
Term
Usually cardiogenic but prevents blood flow to pelvic limbs
Definition
Aortic Thromboembolism
Term
In 20% of cats with HCM
Definition
Aortic Thromboembolism
Term
Top Differential for paraparetic cats
Definition
Aortic Thromboembolism
Term
Second Differential for paraparetic cat
Definition
Traumatic Spinal Fracture/Luxation
Term
Firm painful gastrocnemius and weak femoral pulses in cat
Definition
Aortic Thromboembolism
Term
Streptokinase tx is actually contraindicated due to reperfusion injury and non specific MOA
Definition
Aortic Thromboembolism
Term
Name the six non neural differntials when evaluating for spinal cord disease
Definition
Hip Dysplasia Cranial Cruciates Pelvic Fracture Polyarthritis Prostatitis Pancreatitis
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