Term
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Definition
Unresponsive to therapy
Low or non ringed sideroblasts
Macrocytic ovalocytes
<1% blasts in the peripheral blood
<5% blasts in the bone marrow
WBC count and platelet count are normal |
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Term
| Refractory Anemia with Ringed Sideroblasts (FAB) |
|
Definition
Increased ringed sideroblasts
Hypercellular bone marrow
WBC count is decreased
Otherwise similar to Refractory Anemia |
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Term
| Refractory Anemia with Excess Blasts (FAB) |
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Definition
Cytopenia in two cell lines
Peripheral blood has <5% blasts
Hypercellular bone marrow with <20% blasts
Increased ringed sideroblasts
Hypogranular neutrophils
Pseudo-pelger-huets
Fever, bleeding, increased infections
Platelets are giant and have abnormal granulation |
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Term
| Refractory Anemia with Excess Blasts in Transformation (FAB) |
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Definition
>5% blasts in the peripheral blood
>20% blasts in the bone marrow
Classified as a leukemia under WHO
Auer rods
Variable number of sideroblasts |
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|
Term
| Refractory Anemia with Excess Blasts (WHO) |
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Definition
2 Types
-First has 5-9% blasts
-Second has 10-19% blasts |
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Term
| Myelodysplastic Syndrome with Isolated del(5q) |
|
Definition
Hypolobulated Megakaryocytes
Erythroid Hypoplasia
Decreased platelets |
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Term
| Chronic Myelomonocytic Leukemia |
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Definition
WHO wants it removed from MDS
<5% blasts in the peripheral blood
Increased monocytes
<20% blasts in the bone marrow
Ringed sideroblasts
Splenomegaly
Lab tests include the levels of serum and urine lysozymes
50% of the patients have hypogammaglobulinemia |
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