Term
| When are bactericidal antibiotics mandated over bacteriostatic? |
|
Definition
| In the neutropenic patient |
|
|
Term
| When is rapid renal excretion an advantage? a disadvantage? |
|
Definition
Advantage: treatment of UTIs
Disadvantage: systemic or soft tissue infections |
|
|
Term
| Advantage/Disadvantage of broad spectrum antibiotics? |
|
Definition
A: kills many potential pathogens
D: disruption of normal flora, could lead to super-infection |
|
|
Term
| MOA of quinolones & fluoroquinolones |
|
Definition
| DNA replication (DNA gyrase) |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| MIC is now usually found using what? What is the less useful test it replaced? |
|
Definition
| E-Strips; Kirby-Bauer Disc Diffusion |
|
|
Term
| What feature is crucial for treatment of CNS infections? |
|
Definition
| Ability to cross blood brain barrier |
|
|
Term
| What percentage of Americans are allergic to penicillin? Of these, what percent is allergic to cephalosporins? |
|
Definition
|
|
Term
| What route of administration is preferred in life-threatening infections? |
|
Definition
|
|
Term
| Entire quantity of drug is given IV in a short period of time to obtain high plasma levels and increase killing power |
|
Definition
|
|
Term
| Major indications for combination antimicrobial therapy |
|
Definition
-mixed infections
-severe infections of unknown etiology |
|
|
Term
| Calculate creatinine clearance in 50 year old male, 175 lbs, serum Cr = 1mg/dL |
|
Definition
| ((140-50)x 80kg)/(72 x 1mg/dL) = 100ml/min |
|
|
Term
| What group of drug has a different spectrum of activity but shares some structural similarities with penicillin? |
|
Definition
|
|
Term
| What characteristic increases with each generation of cephalosporins? |
|
Definition
|
|
Term
| Most common ADR of cephalosporins |
|
Definition
|
|
Term
| Which 3rd generation cephalosporin has good anti-pseudomonal activity? |
|
Definition
|
|
Term
| Consequence of active tubular secretion |
|
Definition
|
|
Term
| Strong protein binding of antibiotics = ? |
|
Definition
| Longer duration of action |
|
|
Term
| What are 1st Gen. cephalosporins most useful for? |
|
Definition
| Gram + infections. Also, UTIs & prophylaxis |
|
|
Term
| Useful as single oral dose for N. gonorrheae |
|
Definition
|
|
Term
| Which generation of cephalosporins are often used for nosocomial infections & serious aerobic Gram (-) infections? |
|
Definition
|
|
Term
| Workhorse of 1st Gen cephalosporins |
|
Definition
|
|
Term
| Activity against Bacteroides fragilis |
|
Definition
|
|
Term
| Broadest spectrum drug available |
|
Definition
|
|
Term
| Imipenem combined with this drug to slow renal breakdown |
|
Definition
|
|
