where: agonist at presynaptic GABA-b receptors on spinal interneurons

what: prevents the release of glutamate and aspartate from spinal interneurons

adverse: drowsiness>dissiness>weakness

**drug of choice for MS spasticity.

use for spasticity from cervical spondylosis and trigeminal neuralgia

where: agonist at presynaptic alpha-2 receptors (CNS)

What: prevents the release of NE

Adverse: Dizziness>drowsiness

**second line drug- more expensive, renal issues

blocks reuptake of serotonin and NE at nerve endings, can cause sedation and dry mouth

Facilitates postsynaptic GABA-a action, thereby increasing chloride conductance and hyperpolarization, can cause sedation

calcium modulator- can cause dizziness, ataxia, and excessive sedation

where: works at sarcoplasmic reticulum

what: prevents the release of calcium from SR and prevents actin-myosin contraction

Adverse: weakness>dizziness>hepatotoxicity

also can cause phlebitis

**first line for malignant hypertension and neuroleptic malignant syndrome