Shared Flashcard Set

Details

Muscarinic Antagonists
Smooth Muscles for M1-M3 Receptors
8
Medical
Professional
01/08/2013

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Cards

Term
Atropine
Definition
M1-3 antagonist capable of crossing BBB

antidote myectism (mushroom poisening) and organophosphates

Decreases HR initially followed by a huge BP and tachycardia at higher doese

Mainly used to decrease pulmonary/salvatory secretions before surgery
Term
Scopolamine
Definition
Crosses BBB faster than atropine

Used as a seditive and amnesic

can be used for motion sickness and to cause dry mouth
Term
Oxybutynin
Definition
Used to treat over active bladder/spasms M3>>>m1
and urinary inconinence..

Given gel-->skin due to lack of complaince
Term
Tolterodine
Definition
Better Tx overactive bladder
M3 antagonist exclusively
Very long t1/2
Term
Ipratropium
Definition
Will not cross BBB
used as a nonspecific (M1-M3) bronchodilator. improves mucocilliary clearance
Term
Tiotropium
Definition
Used for COPD/asthma M1/M3>M2
Term
Pirenzepine
Definition
M1>M2/M3 to treat gastric ganglionic excretion of HCL

Anti-diahreal drug
Term
ACUTE Muscarinic antagonist poisening
Definition
Mad as a hatter (agitation Hallucination)
Hot as pistol (increase T, decrease Sweat)
Blind as a bat (Mydriasis_
Red as a beat (flushing due to HR up)
Dry as a bone (decrease salvation)
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